Evaluation of Antiinflammatory, Antioxidant and Antiproliferative Activities of Quassia borneensis Noot. (Simaroubaceae) Extracts

Kamarulzaman, Firdaus; Nuddin, Julenah Ag; Lim, Kai Li; Adam, Aishah; Hamzah, Ahmad Sazali; Ghazali, Ahmad Rohi

doi:10.17576/jskm-2017-1501-05

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…The compounds identified among others are quassin and linoleic acid. Quassin is a triterpene and has been used as antihypertensive, antioxidant, antiinflammatory and anti-proliferative agent as reported by Kamarulzaman et al (2017). Therefore, based on this metabolite identified from T. indica leaves methanol extract, it could be considered as a natural alternative to antioxidants in metabolic disorder in which level of free radical increased.…”

Section: Discussionmentioning

confidence: 97%

In vitro and in vivo analysis of the antioxidant potentials of methanolic extract of Tamarindus indica leaves

Garba,

Bello,

Bashir

et al. 2023

Nig. J. Biochem. Mol. Biol.

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This study evaluated the antioxidant potentials of methanolic extract of Tamarindus indica leaves using in vitro and in vivo assays. reliminary qualitative screening of phytochemicals revealed the presence of alkaloids, flavonoids, saponins, tannins, cardiac glycosides and steroids. The result of the acute toxicity test of the extracts revealed the LD50 to be above 5000 mg/kg through both oral and intra-peritoneal routes. Both the in vitro and in vivo assays were carried out. The reducing power (0.45±0.007 μg/ml) was recorded for T. indica with a difference of 0.77% in comparison to the control and DPPH value (68.10 ± 0.007%) with a significant increase compared to ascorbic acid. The in vivo analysis shows that lipid peroxidation, superoxide dismutase and catalase activities have values of 22.75 ± 9.29 nmol/mg, 1.60 ± 0.03 U/ml and 0.003±0.001 μmol/mg, respectively. The values for superoxide dismutase and lipid peroxidation were significantly different compared to the control (1.48 ± 0.03 U/ml and 24.54 ± 9.29 nmol/mg, respectively) while the value for catalase activity was not significant compared to the control (0.0025 ± 0.001 μmol/mg). The liquid chromatography mass spectrometry revealed the presence of some important metabolite; linoleic acid and quassin, among others, which are antioxidant. Based on the results obtained, the T. indica leaves contain vital metabolites with antioxidant potential that could be useful in health management.

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Section: Discussionmentioning

confidence: 97%

In vitro and in vivo analysis of the antioxidant potentials of methanolic extract of Tamarindus indica leaves

Garba,

Bello,

Bashir

et al. 2023

Nig. J. Biochem. Mol. Biol.

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“…Beberapa jenis tanaman yang terdapat pada tingkat pancang juga terdapat pada tingkat semai. Adapun khasiat dari beberapa tanaman yang ditemukan pada tingkatan pancang antara lain B. bracteata untuk obat panas dalam dan kurap [22], N. maingayi memiliki komponen bioaktif berupa saponin dan potensial sebagai anti kanker [23], Q. borneensis untuk antiproliferatif, antioksidan dan anti inflamasi [24], D. rugosa mengandung senyawa bioaktif berupa fenol, alkaloid, tanin dan steroid [25], E. mastersii sangat potensial untuk anti kanker [26] dan Syzygium sp untuk mengatasi penyakit arthritis dan outoimun [27]. Beragamnya khasiat yang dimiliki oleh tanaman-tanaman dari tingkat pancang tersebut membuka peluang untuk diteliti lebih lanjut sehingga dapat menjadi produk obatobatan baik dalam bentuk herbal maupun sudah dalam bentuk fitofarmaka.…”

Section: Gambar 5 Jumlah Spesies Tumbuhan Obat Dihutan Kantuk Berdasarkan Pada Tingkat Pertumbuhanunclassified

Inventarisasi Tumbuhan Berkhasiat Obat di Hutan Kantuk Desa Paoh Benua Kabupaten Sintang

et al. 2021

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Penelitian ini bertujuan untuk menginventarisasi jenis dan potensi tumbuhan berkhasiat obat yang terdapat dihutan Kantuk Desa Paoh Benua Kecamatan Sepaok Kabupaten Sintang. Penelitian ini diawali dengan membuat sebuah klaster berbentuk persegi yang berjarak 100 m, dan disetiap sudut dan bagian tengah klaster terdapat plot berbentuk lingkaran dengan jari-jari 17,8 m. Setiap plot dibuat empat buah subplot bentuk lingkaran yang terdiri dari subplot untuk tingkat semai dengan jari-jari 1 m, pancang berjari-jari 2 m, tiang berjari-jari 5 m dan pohon berjari-jari 17,8 m. Data jenis tumbuhan di identifikasi nama ilmiahnya dan besarnya potensi tumbuhan di analisis dengan kerapatan (individu/Ha) dan kerapatan relatif (%). Hasil penelitian menunjukkan bahwa di hutan Kantuk terdapat 34 jenis tumbuhan obat. Jenis tumbuhan yang paling dominan atau memiliki kerapatan dan kerapatan relatif yang tinggi pada tingkat semai (10.500 individu/Ha (52,5%)), pancang (3.500 individu/Ha (36,84%)), tiang (140 individu/Ha (58,33%)) dan pohon (117,28 individu/Ha (38,78%)) adalah Alseodaphne sp. Perlindungan terhadap hutan Kantuk dan keanekaragaman jenis tumbuhan obatnya perlu dilakukan melalui peningkatan statusnya menjadi hutan yang bernilai konservasi tinggi (NKT).

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“…This confers protection for the skin against UV light penetration as well as neutralising reactive oxygen species (ROS) that epidermal layer only, the rays damage DNA which in turn causes mutations. This combination of ROS formations and mutations ultimately contribute to the development of skin cancer (Sander et al, 2003;Pfeifer and Besaratinia, 2012;D'Orazio et al, 2013;Kamarulzaman et al, 2017;Pavel et al, 2017;Nagapan et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Viability and Antioxidant Effects of Traditional Cooling Rice Powder (bedak sejuk) Made from Oryza sativa ssp. Indica and Oryza sativa ssp. japonica on UVB-Induced B164A5 Melanoma Cells

Ghazali

Muralitharan

Soon

et al. 2020

Asian Pac J Cancer Prev

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Background: Traditional cooling rice powder (bedak sejuk) is a fermented rice-based cosmetic that is applied topically on one's skin, as an overnight facial mask. According to user testimonies, bedak sejuk beautifies and whitens skin, whereby these benefits could be utilised as a potential melanoma chemopreventive agent. Objective: Hence, this study aimed to determine the effects of bedak sejuk made from Oryza sativa ssp. indica (Indica) and Oryza sativa ssp. japonica (Japonica) on UVB-induced B164A5 melanoma cells, and also identify the antioxidant capacities of both types of bedak sejuk. Methods: The optimum dose of Indica and Japonica bedak sejuk to treat the cells was determined via the MTT assay. Then, the antioxidant capacities of both types of bedak sejuk were determined using the FRAP assay. Results: From the MTT assay, it was found that Indica and Japonica bedak sejuk showed no cytotoxic effects towards the cells. Hence, no IC 50 can be obtained and two of the higher doses, 50 and 100 g/L were chosen for treatment. In the FRAP assay, Indica bedak sejuk at 50 and 100 g/L showed FRAP values of 0.003 ± 0.001 μg AA (ascorbic acid)/g of bedak sejuk and 0.004 ± 0.0003 μg AA/g of bedak sejuk. Whereas Japonica bedak sejuk at 50 g/L had the same FRAP value as Indica bedak sejuk at 100 g/L. As for Japonica bedak sejuk at 100 g/L, it showed the highest antioxidant capacity with the FRAP value of 0.01 ± 0.0007 μg AA/g of bedak sejuk which was statistically significant (p < 0.05) when compared to other tested concentrations. Conclusion: In conclusion, Japonica bedak sejuk has a higher antioxidant capacity compared to Indica bedak sejuk despite both being not cytotoxic towards the cells. Regardless, further investigations need to be done before bedak sejuk could be developed as potential melanoma chemoprevention agents.

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Evaluation of Antiinflammatory, Antioxidant and Antiproliferative Activities of Quassia borneensis Noot. (Simaroubaceae) Extracts

Abstract: Quassia borneensis has been traditionally used as

Cited by 3 publications

References 23 publications

<i>In vitro</i> and <i>in vivo</i> analysis of the antioxidant potentials of methanolic extract of <i>Tamarindus indica</i> leaves

<i>In vitro</i> and <i>in vivo</i> analysis of the antioxidant potentials of methanolic extract of <i>Tamarindus indica</i> leaves

Inventarisasi Tumbuhan Berkhasiat Obat di Hutan Kantuk Desa Paoh Benua Kabupaten Sintang

Viability and Antioxidant Effects of Traditional Cooling Rice Powder (bedak sejuk) Made from Oryza sativa ssp. Indica and Oryza sativa ssp. japonica on UVB-Induced B164A5 Melanoma Cells

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