Evaluation of antifungal effect of iron‐oxide nanoparticles against different Candida species

Abstract

Iron-oxide nanoparticles (IONPs) have been widely favoured due to their biodegradable, low cytotoxic effects and having reactive surface which can be altered with biocompatible coatings. Considering various medical applications of IONPs, the authors were encouraged to study whether IONPs could be effective against fungal infections caused by Candida species. In this study, IONPs were characterised by scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and vibrating sample magnetometer. The goal of this study was to evaluate the antifungal activity of IONPs against different Candida spp. compared with fluconazole (FLC). IONPs were spherical with the size of 30-40 nm. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of IONPs ranged from 62.5 to 500 µg/ml and 500 to 1000 μg/ml, respectively. The MIC and MFC of FLC were in range of 16-128 μg/ml and 64-512 μg/ml, respectively. The growth inhibition value indicated that Candida tropicalis, Candida albicans and Candida glabrata spp. were most susceptible to IONPs. The finding showed that the IONPs possessed antifungal potential against pathogenic Candida spp. and could inhibit the growth of all the tested Candida spp. Further studies, both in vitro and in vivo (including susceptibility, toxicity, Probability of kill (PK) and efficacy studies) are needed to determine whether IONPs are suitable for medicinal purposes.

Antifungal effects of Lactobacillus acidophilus and Lactobacillus plantarum against different oral Candida species isolated from HIV/ AIDS patients: an in vitro study

“…At present, development of resistant fungal strains and treatment failures following high or long-term use of antifungal drugs have increased in immunocompromised patients [10,11]. Therefore, finding an alternative bio-ecological method for better control and treatment of fungal infections has been suggested [12]. The aim of the present study was to investigate the ability of L. acidophilus and L. plantarum to inhibit the growth of different oral Candida species isolated from HIV/AIDS patients under in vitro conditions.…”

Effect of biogenic selenium nanoparticles on ERG11 and CDR1 gene expression in both fluconazole-resistant and -susceptible Candida albicans isolates

“…To date, the antifungal effects of different nanoparticles, such as iron NPs, silver NPs, and gold NPs, have been studied [ 20 - 23 ]. The Se NPs increase the efficiency of glutathione peroxidase and thioredosin reductase [ 24 ] .…”

Evaluation of Antibacterial Activity of Iron Oxide Nanoparticles Against Escherichia coli

“…26 Engineering designs, physiochemical characteristics, biomedical applications, toxicity and magnetic nanotoxicology of iron oxide nanoparticles have been discussed. 27 In this study, we explored the antibacterial activity of iron oxide nanoparticles against a common bacterial strain.…”