Evaluation of Antifungal and Antibacterial Activities of Aromatic Metabolites From Lichens

Piovano, Marisa; Garbarino, Juan A.; Giannini, Fernando; Correche, Estela; Feresin, Gabriela Egly; Tapia, Alejandro; Zacchino, Susana; Enriz, Ricardo D.

doi:10.4067/s0366-16442002000300006

Cited by 30 publications

(58 citation statements)

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“…This compound, when evaluated against S. aureus showed high MIC, between 80-160µg/mL. In contrast to these results, Piovano et al (2002) found low MIC (15-17µg/mL) of divaricatic and difractaic acids against S. aureus. It is known that phenolic compounds, in general, are capable of ionic dissociation (Mueller, 2001;Randhir et al, 2004), which makes possible to justify the antimicrobial activity of purified barbatic acid.…”

Section: Antimicrobial Assayscontrasting

confidence: 50%

“…Lichen substances have been used for centuries (Llano, 1951). Their metabolites possess several biological properties such as antitumor (Santos et al, 2006), antiinflamatory (Vijayakumar et al, 2000;Maia et al, 2002), antimicrobial (Piovano et al, 2002;Falcão et al, 2002;Ingólfsdóttir, 2002), antiparasitary (Carvalho et al, 2005), besides their action as UV sun blockers (Rancan et al, 2002) and efficiency as bioaccumulators and bioindicators of air quality, due to their ability of retaining contaminants, mainly heavy metals (Krishna et al, 2003;Monnet et al, 2005). The presence of phenolic derivatives in lichen is determinant for its antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

“…Those substances come from the secondary metabolism and are known as lichen acids. The production of these acids can vary from 0,1 to 10% of thallus dry weight, depending on the environmental conditions (Piovano et al, 2002). Lichen substances have been used for centuries (Llano, 1951).…”

Section: Introductionmentioning

confidence: 99%

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Cladia aggregata (lichen) from Brazilian northeast: chemical characterization and antimicrobial activity

Martins¹,

Lima²,

Silva³

et al. 2010

Braz. arch. biol. technol.

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Section: Antimicrobial Assayscontrasting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

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Cladia aggregata (lichen) from Brazilian northeast: chemical characterization and antimicrobial activity

Martins¹,

Lima²,

Silva³

et al. 2010

Braz. arch. biol. technol.

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“…Es importante mencionar que una de las limitaciones en el presente estudio es que no se realizó la identificación de los metabolitos secundarios presentes en los extractos realizados, pero con base a la literatura; las sustancias catalogadas como tí-picas en líquenes son dépsidos, depsidonas, depsonas, dibenzofuranos y ácidos úsnicos 18 ; en especial este último es característico del genero Usnea el mismo que fue probado en otro estudio mostrando una marcada capacidad de inhibir el crecimiento y esporulación de hongos fitopatógenos como Aspergillus flavus 19 tal y como sucedió en la presente investigación con Aspergillus sp1.…”

Section: Discussionunclassified

Evaluación de la actividad antifúngica del extracto de Usnea laevis en hongos fitopatógenos

Ordoñez

2018

Bol. Micol.

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REsumEnLos líquenes son producto de una asociación simbiótica entre un hongo y alga y/o cianobacteria; esta simbiosis produce una serie de metabolitos secundarios o sustancias liquénicas únicas, las mismas que son aisladas a partir de sus extractos y que han presentado una marcada actividad antibiótica y antifúngica. Considerando que en el Ecuador no se tienen antecedentes acerca de este tipo de estudios, el objetivo planteado fue el evaluar la actividad antifúngica del extracto liquénico de Usnea laevis frente a hongos fitopatógenos.En el presente estudio las sustancias liqué-nicas almacenadas en el talo de Usnea laevis fueron extraídas con metanol y etanol. La actividad antifúngica in vitro de estos extractos fue probado frente a géneros de hongos fitopatógenos previamente aislados (Aspergillus, Penicillium y Rhizopus stolonifer); añadiéndolo al medio de cultivo Agar Papa Dextrosa (PDA) a una concentración de 0,5%; determinándose el porcentaje de inhibición. Los datos fueron analizados estadísticamente y se realizó la clasificación del extracto en base a su porcentaje de inhibición según la OILB.El extracto metanólico y etanólico de Usnea laevis mostró una mayor efectividad frente a Rhizopus stolonifer, inhibiendo más del 50% de su crecimiento, a diferencia de Penicillium y Aspergillus cuyo porcentaje de inhibición fue mucho menor y mostraron diferencias estadísticamente significativas. El extracto liquénico fue moderadamente tóxico para Rhizopus stolonifer, ligeramente tóxico para Aspergillus sp 1 y Penicillium sp e inocuo para Aspergillus sp 2. AbstRACtA lichen is an organism product of a symbiotic association between a fungus and algae and Bol.Micol. 2018; 33(1):01-08 FItOPAtOLOGÍA

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“…Numerous biological investigations have showed that secondary lichen metabolites have a broad range of biological activities including antibiotic [13] , antiviral [14] , analgesic and antipyretic [15] , antifungal [16,17] , anti-inflammatory [18] , cytotoxic and antimicrobial [19] , antiulcerogenic and antioxidant [20] and immunologic modulator [21] .…”

Section: öZetmentioning

confidence: 99%

Usnik Asitin Broylerlerdeki Anticoccidial Etkinliği

Güven¹,

Avcıoğlu²,

Aslan³

et al. 2016

Kafkas Univ Vet Fak Derg

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This experiment was conducted to investigate if usnic acid, a lichen metabolite, exerts therapeutic action against coccidiosis. A total of 160 one-day-old male Ross 308 broiler chicks were divided into 5 experimental groups (A-E), each replicated in 4 pens of 8 chicks. At 16 days of age Groups B-E were infected orally with a mixture of purified oocysts including 30 x 10 4 sporulated oocysts from field isolates of E. acervulina, E. brunetti, E. maxima, E. mitis, E. praecox and E. tenella, whereas Group A was remained uninfected. Seven days after the coccidiosis induction, infected birds were divided into 4 groups to receive orally with 20 mg usnic acid (Group C), 100 mg usnic acid (Group D) and 7 mg toltrazuril (Group E) per kg body weight. The birds in Group B were untreated and served as infected control. The experiment was terminated at 29 days of age. As a result of the study it was evaluated that infected birds had lower feed intake and body weight and worse feed conversion, higher intestinal lesion score, longer small intestine and cecum, and higher fecal oocyst count than healthy birds. The anticoccidial effect of usnic acid at 100 mg/kg application dose was comparable to toltrazuril as reflected by alleviations in performance and pathology findings. In conclusion, it is demonstrated that usnic acid possesses some anticoccidial effects, but not nearly as good as toltrazuril. Keywords: Lichen, Usnic acid, Toltrazuril, Broiler, Coccidiosis Usnik Asitin Broylerlerdeki Anticoccidial Etkinliği ÖzetBu çalışmada, bir liken metaboliti olan usnik asitin coccidiosise karşı terapötik etkinliğinin araştırılması amaçlanmıştır. Toplam 160 adet, 1 günlük yaştaki erkek Ross 308 civciv, her bir grup 4 tekerrürlü olacak şekilde 5 deneysel gruba (A-E) ayrılmıştır. Hayvanlar 16 günlük yaşa geldiğinde Grup B-E'dekiler E. acervulina, E. brunetti, E. maxima, E. mitis, E. praecox ve E. tenella'nın saha izolatlarından elde edilmiş inokulumdan 30 x 10 4 sporlanmış oocyst ile enfekte edilmiştir. Grup A'da yer alanlar civcivler ise enfekte edilmeden kontrol olarak bırakılmıştır. Hastalık oluşturulduktan 7 gün sonra, enfekte hayvanlara ağız yolu ile 20 mg/kg usnik asit (Grup C), 100 mg/kg usnik asit (Grup D) ve 7 mg/kg toltrazuril (Grup E) uygulanmış; B grubundaki enfekte hayvanlara tedavi uygulanmadan enfekte kontrol olarak bırakılmıştır. Broylerler 29 günlük olduğunda çalışma sona erdirilmiştir. Enfekte hayvanların sağlıklı hayvanlara kıyasla daha düşük yem tüketimi, vücut ağırlığı ve yemden yararlanma oranına; daha yüksek lezyon skoruna, daha uzun bağırsak uzunluğuna ve daha yüksek oocyst sayısına sahip olduğu tespit edilmiştir. Performans ve patolojik bulgulardaki değişimler göz önünde bulundurulduğunda 100 mg/kg dozda uygulanan usnik asitin toltrazuril ile karşılaştırılabilecek derecede anticoccidal etkinliğe sahip olduğu belirlenmiştir. Sonuç olarak; usnik asitin bazı anticoccidial etkinliklere sahip olduğu ancak bu etkilerin toltrazuril kadar güçlü olmadığı kanısına varılmıştır.

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Evaluation of Antifungal and Antibacterial Activities of Aromatic Metabolites From Lichens

Cited by 30 publications

References 0 publications

Cladia aggregata (lichen) from Brazilian northeast: chemical characterization and antimicrobial activity

Cladia aggregata (lichen) from Brazilian northeast: chemical characterization and antimicrobial activity

Evaluación de la actividad antifúngica del extracto de Usnea laevis en hongos fitopatógenos

Usnik Asitin Broylerlerdeki Anticoccidial Etkinliği

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