Evaluation of antifungal activity of cinnamaldehyde against Cryptococcus neoformans var. grubii

Neelabh, .; Singh, Karuna

doi:10.1007/s12223-020-00806-4

Cited by 9 publications

(4 citation statements)

References 40 publications

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“…But in this study, 210 mg/kg body weight of Cin per os was found effective against mycotoxicosis induced by TeA in mice. In another study, carried out by Neelabh and Singh (2020), 312 mg/kg Cin on oral administration showed anti-cryptococcal activity in mice 15 .…”

Section: Discussionmentioning

confidence: 91%

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Evaluation of prophylactic efficacy of cinnamaldehyde in murine model against Paradendryphiella arenariae mycotoxin tenuazonic acid-induced oxidative stress and organ toxicity

Kumari

Singh

2021

Sci Rep

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Cinnamaldehyde (Cin) is a natural product obtained from cinnamon and is reported to have a potential anti-fungal, anti-oxidant, anti-inflammatory and anticancer effect. The present study investigated the possible protective role of Cin against tenuazonic acid-induced mycotoxicity in the murine model. Tenuazonic acid (TeA), a toxin produced by Alternaria is a common contaminant in tomato and tomato-based products. Here, Swiss male mice were administered with TeA isolated from Paradendryphiella arenariae (MW504999) (source-tomato) through injection (238 µg/kg BW) and ingestion (475 µg/kg BW) routes for 2 weeks. Thereafter, the prophylaxis groups were treated with Cin (210 mg/kg BW). The experiment was carried out for 8 weeks. The treated groups were compared to the oral and intra-peritoneal experimental groups that received the toxin solely for 8 weeks. Haematological, histopathological and biochemical aspects of the experimental and the control mice were analysed. Sub-chronic intoxication of mice with TeA showed elevated malondialdehyde (MDA), reduced catalase (CAT) and superoxide dismutase (SOD) production; abnormal levels of aspartate transaminase (AST) and alanine transaminase (ALT). Treatment with Cin reversed TeA-induced alterations of antioxidant defense enzyme activities and significantly prevented TeA-induced organ damage. Thus, cinnamaldehyde showed therapeutic effects and toxicity reduction in TeA induced mycotoxicosis.

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Section: Discussionmentioning

confidence: 91%

“…Cinnamaldehyde is an active ingredient of cinnamon which is obtained from the trees of Cinnamamum sps. The antifungal activity of Cin has already been reported against Cryptococcus neoformans and filamentous fungi 14 , 15 . Cin also exhibits anti-fungal activity against Geotrichum citri-aurantii 16 .…”

Section: Introductionmentioning

confidence: 93%

Evaluation of prophylactic efficacy of cinnamaldehyde in murine model against Paradendryphiella arenariae mycotoxin tenuazonic acid-induced oxidative stress and organ toxicity

Kumari

Singh

2021

Sci Rep

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“…Concurring with expectations, after treatment with cinnamaldehyde, the mycelia of F. solani could be stained by PI, and the fluorescence intensity increased from weak to strong monotonically depending on the concentration of EO (Figure 3), which suggested that the membrane integrity was impaired. Similarly, Neelabh and Singh (2020) found that the extracellular PI could penetrate and integrate into DNA of Cryptococcus neoformans var. grubii cells treated with cinnamaldehyde.…”

Section: Discussionmentioning

confidence: 92%

The major component of cinnamon oil as a natural substitute against Fusarium solani on Astragalus membranaceus

Wang

Zhang

et al. 2022

Journal of Applied Microbiology

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Aims: Root rot caused by Fusarium solani is an important disease seriously affecting the yield and quality of Astragalus membranaceus. Therefore, this study was performed to elucidate the antifungal activities and mechanisms of cinnamaldehyde treatment against F. solani and its control effect for A. membranaceus root rot. Methods and Results: Cinnamaldehyde significantly inhibited mycelial growth and spore germination of F. solani in dose-dependent, and the median effective concentration was 178.68 μl l −1 . Furthermore, scanning electron microscopy, propidium iodide staining, cell leakage experiments and ergosterol quantitation illuminated that cinnamaldehyde could alter the mycelial morphology, damage the plasma membrane and hinder the biosynthesis of ergosterol. Besides, cinnamaldehyde induced the generation of reactive oxygen species by synergistically upregulating the genes encoded subunits for NADPH oxidase. The disease suppression efficacy of 600 μl l −1 cinnamaldehyde against A. membranaceus root rot was 92.98 ± 6.08% (p < 0.05) under greenhouse conditions. Conclusions: This study proved that cinnamaldehyde could markedly inhibit the growth of F. solani in vitro and effectively suppress the occurrence of A. membranaceus root rot, perhaps by inducing oxidative damage, which results in the distortion of F. solani, and the destruction of cell membrane integrity and permeability. Significance and Impact of the Study: This study first explores the antifungal mechanisms of cinnamaldehyde against F. solani in vivo and vitro, thereby providing a promising candidate for disease biocontrol.

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“…[7,8] Cinnamaldehyde (CIN, 3-phenylprop-2-enal, C 9 H 8 O), an active ingredient of cinnamon oils from cinnamon bark (Cinnamomum cassia; Lauraceae), has been used for centuries as a traditional medicine and flavoring agent in Eastern Asia. [9] Previous studies have shown that CIN has anti-oxidant, [10] anti-microbial, [11,12] and anti-inflammatory properties. [13][14][15] CIN regulates inflammation during UC by inhibiting NLRP3 inflammasome activation in macrophages, [15] suppressing Th17 cell differentiation, [16] and modulating JAk2/ STAT3/SOCS3 signaling.…”

Section: Introductionmentioning

confidence: 99%

Cinnamaldehyde Ameliorates Dextran Sulfate Sodium‐Induced Colitis in Mice by Modulating TLR4/NF‐κB Signaling Pathway and NLRP3 Inflammasome Activation

Tan

Wen

Han

et al. 2023

Chemistry & Biodiversity

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Ulcerative colitis (UC) is a chronic inflammatory gastrointestinal disease mainly associated with immune dysfunction and microbiota disturbance. Cinnamaldehyde (CIN) is an active ingredient of Cinnamomum cassia with immunomodulatory and anti‐inflammatory properties. However, the therapeutic effect and detailed mechanism of CIN on UC remains unclear, and warrant further dissection. In this study, network pharmacology and molecular docking analyses were introduced to predict the potential targets and mechanism of CIN against UC. The therapeutic effect and the predicted targets of CIN on UC were further validated by in vivo and in vitro experiments. Seven intersection targets shared by CIN and UC were obtained, and four hub targets, i. e., toll‐like receptor 4 (TLR4), transcription factor p65 (NF‐κB), NF‐kappa‐B inhibitor alpha (IκBα), prostaglandin G/H synthase 2 (COX2) were acquired, which were mainly involved in NF‐κB, tumor necrosis factor (TNF), Toll‐like receptor and NOD‐like receptor signaling pathways. CIN alleviated the symptoms of dextran sulfate sodium (DSS)‐induced colitis by decreasing the disease active index (DAI), restoring colon length, and relieving colonic pathology. CIN attenuated systemic inflammation by reducing serum myeloperoxidase (MPO), TNF‐α, interleukin‐6 (IL‐6), and interleukin‐1β (IL‐1β), down‐regulating TLR4, phosphorylated‐NF‐κB (p‐NF‐κB), phosphorylated‐IκBα (p‐IκBα), and COX2 expression in colonic tissues, and decreasing NOD‐like receptor protein 3 (NLRP3), Caspase‐1, and IL‐1β protein expression in lipopolysaccharide (LPS)‐stimulated RAW264.7 cells. These results indicate that CIN alleviates DSS‐induced colitis inflammation by modulating TLR4/NF‐κB signaling pathway and NLRP3 inflammasome activation.

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Evaluation of antifungal activity of cinnamaldehyde against Cryptococcus neoformans var. grubii

Cited by 9 publications

References 40 publications

Evaluation of prophylactic efficacy of cinnamaldehyde in murine model against Paradendryphiella arenariae mycotoxin tenuazonic acid-induced oxidative stress and organ toxicity

Evaluation of prophylactic efficacy of cinnamaldehyde in murine model against Paradendryphiella arenariae mycotoxin tenuazonic acid-induced oxidative stress and organ toxicity

The major component of cinnamon oil as a natural substitute against Fusarium solani on Astragalus membranaceus

Cinnamaldehyde Ameliorates Dextran Sulfate Sodium‐Induced Colitis in Mice by Modulating TLR4/NF‐κB Signaling Pathway and NLRP3 Inflammasome Activation

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