Evaluation of Antidiarrheal Potential ofEmblica officinalis.

Abstract

The antidiarrheal potential of the methanol extract of the fruit of Emblica officinalis. Gaertn. Euphorbiaceae was evaluated using several experimental models of diarrhea in Wistar albino rats. The methanol extract showed a significant inhibitory effect on rats with diarrhea induced by castor oil and magnesium sulfate. The methanol extract produced a significant reduction in gastrointestinal motility in charcoal meal tests in rats. It also significantly inhibited PGE-induced enteropooling as compared to control animals. The results obtained establish the efficacy and substantiate the use of this herbal remedy as a nonspecific treatment for diarrhea in folk medicine.

The antidiarrheal and spasmolytic activities of Phyllanthus emblica are mediated through dual blockade of muscarinic receptors and Ca2+ channels

“…The observed antidiarrheal activity of Phyllanthus emblica fruit extract in two species, such as, in rats, mediated through inhibition of prostaglandins action (Perianayagam et al, 2005) and in mice through antimuscarinic and Ca 2+ antagonist effects, provides a sound mechanistic base for its effectiveness in diarrhea. This is also in accordance with the general understanding that plants contain multiple active constituents with effect enhancing activities (Gilani and Rahman, 2005).…”

“…Antimuscarinic drugs and CCBs are known to be effective as antispasmodic, anti-motility and antidiarrheal (Lee et al, 1997;Brown and Taylor, 2006;Pasricha, 2006). Hence, the presence of dually acting spasmolytic activity in the plant extract might be contributing towards its effectiveness in diarrhea and abdominal spasm, in addition to the reported antidiarrheal activity related with inhibition of prostaglandins synthesis (Perianayagam et al, 2005).…”

“…Moreover, it has also been reported to possess antioxidant Reddy et al, 2009), antiaging (Datta et al, 2009), chondroprotective (Sumantran et al, 2008), chemoprotective (Sultana et al, 2008), anti-inflammatory (Sharma et al, 2003;Nicolis et al, 2008), hepatoprotective (Panchabhai et al, 2008), antibacterial (Saeed and Tariq, 2007), antipyretic and analgesic (Perianayagam et al, 2004) activities. Despite the availability of various studies on different aspects of Phyllanthus emblica and a preliminary report showing its efficacy in diarrhea (Perianayagam et al, 2005), it has not been widely studied for the possible mode(s) of action using both the in vivo and in vitro assays, for its medicinal use in hyperactive gut disorders. In this study, we provide evidence that the plant exhibits antidiarrheal and antispasmodic activities, mediated possibly through the dual blockade of muscarinic receptors and Ca 2+ channels.…”

Phytochemical and Antioxidant Screening of Amomum Subulatum, Elettaria Cardamomum, Emblica Officinalis, Rosa Damascene, Santalum Album and Valeriana Officinalis and Their Effect on Stomach, Liver and Heart

“…Perianayagam have demonstrated that methanolic extract of fruits of Emblica officinalis reduces gastrointestinal motility and PGE2mediated accumulation of intestinal fluid (enteropooling) which can be related to the presence of tannins in Emblica officinalis extract [35]. Long term administration of Emblica officinalis facilitated myocardial adjustment by boosting endogenous antioxidants and safe guard the rat hearts from oxidative stress coupled with ischemicreperfusion injury [36].…”

Phytochemical and Antioxidant Screening of Amomum Subulatum, Elettaria Cardamomum, Emblica Officinalis, Rosa Damascene, Santalum Album and Valeriana Officinalis and Their Effect on Stomach, Liver and Heart

“…Khan, have described that Emblica officinalis is enlisted as a fundamental plant in Indian indigenous scheme of medication. It belongs to family Euphorbiaceae[26]. It is generally named as Amla, Indian gooseberry or Phyllanthus Emblica.…”