Evaluation of Antidiarrheal Activity of Methanolic Extract of<i>Maranta arundinacea</i>Linn. Leaves

Rahman, Md. Khalilur; Chowdhury, Ashraf Uddin; Islam, Mohammed Taufiqual; Chowdhury, Md. Anisuzzaman; Uddin, Muhammad Erfan; Sumi, Chandra Datta

doi:10.1155/2015/257057

Cited by 51 publications

(49 citation statements)

References 23 publications

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“…The production of ricinoleic acid in the intestine results in inflammation and irritation of the mucosa and the release of mediators like prostaglandins that prevent fluid and electrolyte absorption and increase the intestinal peristaltic movements, this series of events ultimately leading to diarrhea [14,15,18]. By using the castor oil-induced enteropooling model and the charcoal transit method, we showed that the probiotic mixture decreased both the accumulation of fluid into the lumen and intestinal motility.…”

Section: Discussionmentioning

confidence: 95%

“…It is well known that castor oil induces diarrhea through its active metabolite, ricinoleic acid [14,15,18]. The production of ricinoleic acid in the intestine results in inflammation and irritation of the mucosa and the release of mediators like prostaglandins that prevent fluid and electrolyte absorption and increase the intestinal peristaltic movements, this series of events ultimately leading to diarrhea [14,15,18].…”

Section: Discussionmentioning

confidence: 99%

“…That means that the health benefit attributed to one strain is not necessarily applicable to another strain even within the same species and that consequently, efficacy of a specific strain or mixture has to be substantiated by experimental evidence. Therefore, the antidiarrheal effect of our probiotic mixture was evaluated in comparison with the standard drug loperamide using the rat model of castor oil-induced diarrhea, a model extensively used to assess anti-diarrheal substances [13][14][15][16][17][18]. The antinociceptive effect of the probiotic mixture was also assessed in this model.…”

Section: Introductionmentioning

confidence: 99%

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Antidiarrheal and Antinociceptive Effects of a Probiotic Mixture in Rats

Holowacz¹,

Blondeau²,

Guinobert³

et al. 2016

J Prob Health

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Probiotics have been shown to have preventive and therapeutic effects on diarrhea. Because effects tend to be strain specific, benefit of a strain or mixture has to be substantiated by experimental evidence. The aim of this study was to investigate the antidiarrheal and antinociceptive effects of a probiotic mixture (Lactibiane Imedia ® , PiLeJe). Castor oil-induced diarrhea test was performed in Wistar rats following oral administration of probiotics (20 × 10 9 , 30 × 10 9 or 40 × 10 9 CFU/kg), loperamide (5 mg/kg) or vehicle (water; 10 mL/kg). Time to initial evacuation, number of feces and diarrheal feces, fresh weight and water content of the feces and body weight loss were monitored. Behavioral parameters (eye closing, abnormal posture, activity, fur aspect) were used as pain indices. Probable mechanisms of action were evaluated by using the castor oil-induced enteropooling and charcoal meal transit tests. Probiotics significantly and dose-dependently delayed onset time to first feces and had a beneficial effect on all other parameters (p<0.05 versus vehicle). This effect was lower than loperamide on most of parameters evaluated. Loperamide totally stopped diarrhea (100%) but also blocked defecation (by 98.5%) whereas probiotics strongly inhibited diarrhea (>90%) at the two highest doses tested (30 × 10 9 or 40 × 10 9 CFU/kg) without completely blocking defecation (65.7% at 30 × 10 9 CFU/kg). Behavioral parameters were improved with probiotics compared to vehicle, improvement that was not observed with loperamide. Probiotics significantly and dose-dependently decreased the volume of intestinal fluid (p<0.05 versus vehicle) in the enteropooling test and transit time of charcoal meal. These results indicate that the probiotic mixture tested is strongly antidiarrheic through the combination of antimotility and antisecretory properties. Observations are also in favor of an antinociceptive effect. Agents that can decrease both intestinal hypersecretion and motility are very useful in the management of diarrhea therefore, our probiotic mixture could be an effective alternative to standard drugs.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antidiarrheal and Antinociceptive Effects of a Probiotic Mixture in Rats

Holowacz¹,

Blondeau²,

Guinobert³

et al. 2016

J Prob Health

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“…Usually, castor oil is metabolized into ricinoleic acid in the gut, which causes irritation and inflammation in the intestinal mucosa, resulting in the release of inflammatory mediators (prostaglandins). The released prostaglandins initiate vasodilation, smooth muscle contraction and mucus secretion in the small intestines, in experimental it can be considered to be good diarrheagenic agents [27].…”

Section: Sangkareho Leaves (Callicarpa Longifolia Lam) Accordingmentioning

confidence: 99%

Antidiarrheal activity of ethanolic extract of leaves of Sangkareho (Callicarpa longifolia Lam) from Central Kalimantan

2019

Lett Appl NanoBioSci

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Diarrhea is one of the leading causes of preventable death in developing countries including in Indonesia and Malaysia. It has been reported that the leaves of sangkareho (Callicarpa longifolia Lam) is used traditionally as an antidiarrheal treatment in Central Kalimantan. The present study was aimed to evaluate the pharmacological activity against diarrhea using the ethanolic extract of sangkareho leaves. The extract was used for castor oil-induced diarrhea in mice. The extracts were given orally to the mice at 200, 300, 400 mg/kg bodyweight and loperamide was used as a standard drug for diarrhea. The results showed % inhibition of diarrhea with values of no detected, 42.62%, 81.97%, 70.49% at 200, 300, 400 mg/kg bodyweight dose levels of the extract and loperamide, respectively as compared to the negative control. It can be considered at a dose level of 400 mg/kg bodyweight the extract has a greater anti-diarrheal effect than loperamide. In conclusion, ethanolic extract of sangkareho leaves (Callicarpa longifolia Lam) has anti-diarrheal activity and this supports the use of this plant as antidiarrhea in traditional treatment.

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“…100% was considered as the total number of feces of control group. The activity was expressed as percent inhibition of diarrhea [28][29].…”

Section: In Vivo Anti-diarrheal Activity Testmentioning

confidence: 99%

Biological investigations of different leaf extracts of Litsea liyuyingi (Family-Lauraceae)

Laboni¹,

Mahmud²,

Karim³

et al. 2017

IOSRJPBS

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Evaluation of Antidiarrheal Activity of Methanolic Extract ofMaranta arundinaceaLinn. Leaves

Cited by 51 publications

References 23 publications

Antidiarrheal and Antinociceptive Effects of a Probiotic Mixture in Rats

Antidiarrheal and Antinociceptive Effects of a Probiotic Mixture in Rats

Antidiarrheal activity of ethanolic extract of leaves of Sangkareho (Callicarpa longifolia Lam) from Central Kalimantan

Biological investigations of different leaf extracts of Litsea liyuyingi (Family-Lauraceae)

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