Evaluation of Antidiabetic Potential of Sarcostemma brevistigma Wight & Arn. Using Alloxan-Induced Diabetic Murine Model

Abstract

A multimillion-dollar boom is achieved every year by the ethnopharmaceutical companies, creating awareness around the globe to use herbal medicines to stay and live a healthy life. Nearly, two-thirds of the plants were discovered for herbal remedies, and some plants are even endangered to get extinct from the globe for their repeated utility. Sarcostemma brevistigma is one among the undiscovered medicinal plants which belongs to the family Asclepiadaceae found distributed in Indian states of Bihar, Bengal, Konkan, Tamil Nadu, and Kerala. This study was intended to determine the antidiabetic property of plant extract of Sarcostemma brevistigma evidenced by biochemical parameters, antioxidant activity, with the histopathological analysis in diabetic induced mice. Animals that were orally treated with the S. brevistigma extract showed blood glucose lowering effect when compared to the alloxan-induced mice, i.e., from 391.5 ± 6.3 to 193.6 ± 4.3 mg/dL. There is the significant increase in insulin level (P < 0.05) (27.97 ± 1.6 mIU/L) which is comparable to the metformin administered test group (30.35 ± 0.6 mIU/L). A significant difference (P < 0.05) of both ALT and AST levels were observed when compared to the other groups. A significant increase in antioxidant activity (reduced glutathione, malondialdehyde, superoxide dismutase) in plant extract administered group was observed when compared to the other treatment groups. Histopathological studies showed abnormalities in the liver, pancreas, kidney, lungs, heart, and spleen of alloxan-induced diabetic rats. The abnormalities were found to be normalized to a considerable extent after treatment with S. brevistigma extract. The results stood as evidence for S. brevistigma as an active antidiabetic herbal plant.

Ameliorative effect of Annona reticulata L. leaf extract on antihyperglycemic activity and its hepato-renal protective potential in streptozotocin induced diabetic rats

“…Owing to its drastic prevalence, morbidity and mortality, in India diabetes has emerged as a seventh leading killer of early death in 2016. Over 72 million cases of diabetes were reported in India 2017 [ 5 ]. The reports are alarming the world population to be cautious and aware of the disease progression.…”

Glucose-lowering activity of dark tea protein extract by modulating spleen–brain axis of diabetic mice

“…The aqueous extract of Fagonia cretica caused a 45 % decrease in the plasma glucose level at the end of the experimental period (21 d) with the dose of 500 mg/kg (11) . Sarcostemma brevistigma extract (250 mg/kg) was found to reduce by 17•9 % blood glucose at day 21 (12) . Green tea consumption (2 g/kg) reduced 14•3 % of blood glucose in 21 d of diabetic rats (13) .…”

“…Sarcostemma brevistigma extract (250 mg/kg) was found to reduce by 17.9% blood glucose at day 21 (12) . Green tea consumption (2 g/kg) reduced 14.3% of blood glucose in 21 days of diabetic rats (13) .…”

Antidiabetic Activity of Medicinal Plants: An Updated Overview of Streptozotocin and Alloxan-Induced Diabetic Models

“…Sarcostemma brevistigma methanol concentrate can both reduce hyperglycemia and control other blood serum biological parameters. 70 Sidda cordifolia Sidda cordifolia belongs to the Malvaceae family. Ethanolic and aqueous extracts from the entire plant were employed to evaluate the antidiabetic action.…”