Evaluation of antidiabetic activity in Corallocarpus epigaeus rhizomes

Abstract

From these results it can be understood that plant extract showing its pharmacological action on diabetes between the time intervals of 1-2 hr after its administration. This is exactly what the action that is being observed from the standard Glibenclamide group which also shown its action at its 1-2 hr of administration to the animals. Here the statistically significant action of the higher dose of plant extract can be compared with that of the standard Glibenclamide group. From these results it can be understood that the plant extract is capable of inhibiting the elevation of blood glucose level to the extent of the action that has been shown by the standard Glibenclamide group. Particularly at the time interval of 2-4 hr both the Glibenclamide and plant extract at its high dose group that is 400 mg/kg has been significantly inhibited the elevation of the blood glucose levels in the animals.DOI: http://dx.doi.org/10.3329/icpj.v2i3.13581 International Current Pharmaceutical Journal, February 2013, 2(3): 53-56

In vitro anthelmintic activity and phytochemical characterization of Corallocarpus epigaeus (Rottler) Hook. f. tuber from ethyl acetate extracts

“…The ethyl acetate extract showed the presence of alkaloids, tannins, phenol, flavonoid, steroids, saponin, and glycosides. Gnananath et al (2013) reported that the ethanolic extract of C. epigaeus rhizomes contains phenolic compounds, flavonoids, terpenoids, and phytosterols. Preliminary phytochemical analysis of ethyl acetate extract of C. epigaeus tuber indicated the mix of compounds gives better activity.…”

“…Alkaloids are also used as starting materials in the manufacture of steroidal drugs and carry out protective functions in animals, thus are medicinal especially steroidal alkaloids (Maxwell et al, 1995). Isolated pure plant alkaloids and their synthetic derivatives are used as basic medicinal agent for their anthelmintic effects (Gnananath et al, 2013). The presence of these secondary metabolites has contributed to its medicinal value as well as physiological activity (Lewis and Elvin-Lewis., 1977).…”

“…corallocarpscalaride, a pyridine carboxylic ester, designated as corallocarpeonyl ester (Ishnava et al, 2015). Different activity of C. epigaeus is reported for different diseases like antifungal , antibacterial , anticancer (Bhavani and Leelavathi, 2012), antidiabetic (Gnananath et al, 2013), and antioxidant (Thangavel et al, 2014). The earthworms have been used for the initial evaluation of anthelmintic compounds in vitro.…”

High Efficiency In vitro Regeneration and Genetic Stability of Corallocarpus epigaeus - An Endangered Medicinal Plant

“…C. epigaeus is commonly called as Akas Gaddah. C. epigaeus plant is one such important medicinal plants used in treating syphilitis, venereal complaints and chronic dysentery (Kothawade and Siddiqui 2018); it is also effectively used to cure diabetes (Gnananath et al 2013), snakebites (Chandrakala et al 2013) and rheumatism (Uthrapathy et al 2011).…”