Evaluation of antibiotic sensitivity pattern in acute tonsillitis

Abstract

<p class="abstract"><strong>Background:</strong> The use of antibiotics against different pathogens in acute tonsillitis has been the general trend through the years. Penicillin has been the drug of choice for the management. But due to increased incidence of resistance in case of penicillin’s, other antibiotics are also used for the treatment of acute tonsillitis. The study was conducted with the objective to find out the antibiotic sensitivity and susceptibility pattern against microbial pathogens in acute tonsillitis.</p><p class="abstract"><strong>Methods:</strong> Our prospective observational study was carried out in the otorhinolaryngology department in Dr. D. Y. Patil Medical College, Hospital and Research Centre. The period of study was from June 2015 to August 2015. After getting approval from the Institutional Ethics Committee (IEC) throat swabs were collected randomly from 50 patients visiting the ENT OPD. An informed consent was obtained from every patient who was a part of this study before commencing the study. </p><p class="abstract"><strong>Results:</strong> The commonly used antibiotics showed a higher resistance pattern as compared to the less commonly used antibiotics. Ampicillin and Amoxicillin showed poor sensitivity results in case of both <em>Streptococci </em>as well as <em>Staphylococci</em>.</p><p><strong>Conclusions:</strong> Study findings therefore helped in perusing a guarded and judicious use of antibiotics in cases of acute tonsillitis and will thus help in improving the quality of antibiotic therapy provided to the patient. </p>

Pattern of antibiotic resistance of various strains of bacteria causing acute tonsillitis

“…In our study two major gram-positive strains were found, that is, Streptococcus pneumonia (15) and S. aureus (17) and two gram-negative bacteria K. sepsis (23) and P. aeruginosa (19).…”

“…Ampicillin and amoxicillin, in both Streptococci and Staphylococci, showed poor sensitivity results. 18 Paired t test of sensitive and resistant drugs to grampositive bacteria showed a significant difference of p=0.0001 (p<0.05), that is the number of drugs resistant to the gram-positive bacteria is lesser than the number of drugs sensitive, while the same was not noted in gramnegative bacteria. 19,20…”

“…The sensitivity and resistance of antibiotic drugs were noted after doing the culture sensitivity test accurately. The culture and sensitivity test presence of gram-positive species including S. pneumonia (15) and S. aureus (17) and gram-negative bacteria species including K. sepsis (23) and P. aeruginosa (19) A list of 25 antibiotic drugs in gram-negative and 31 drugs in gram-positive strain, their sensitivity and resistance were taken and noted, respectively. Among gram-negative bacteria, the highest sensitivity was observed in imipenem (71.4%), followed by gentamycin (69.0%), piperacillin+tazobactam (61.9%) and meropenem (61.9%).…”

“…Erythromycin showed 76% sensitivity while ciprofloxacin showed a low sensitivity of 35.5% followed by cephalosporins (22.2%). 17 A prospective observational 3 month analysis was performed by Ingale et al 17 Throat swabs were collected randomly from 50 patients attending the ENT OPD.…”

Bacterial Microbiota and Antibiogram Profile in Children With Acute Tonsillitis. A Guide to Treatment.

“…Direct microscopy was done using the isolates from the culture media. 32 The culture and sensitivity was done at the Microbiology laboratory of University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu. The samples collected from Federal Medical Center, Umuahia, were put in ice pack and later refrigerated and sent in batches every 2 days (Wednesday and Fridays).…”