Evaluation of Antibacterial Potential of Crude Extract of Moringa oleifera seed on Orthopaedics Wound Isolates and Characterization of Phenylmethanamine and Benzyl Isothiocyanate Derivatives

Oluduro, Anthonia Olufunke; Idowu, Thomas Oyebode; Aderiye, B. I.; Famurewa, O.; Omoboye, Olumide Owolabi

doi:10.3923/rjmp.2012.383.394

Cited by 13 publications

(5 citation statements)

References 9 publications

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“…Previous reports show a direct role of flavonoids, i.e., complex formation with the soluble extracellular proteins and cell walls of bacteria [ 27 ]. Other studies also validated antibacterial activities against gram-positive and gram-negative bacteria using different extracts of M. oleifera seeds [ 28 , 29 ]. The zone of inhibition in various other studies of antibacterial activity of M. oleifera leaves various solvents was found to be less as compared to the reported in the present study with seeds [ 30 ].…”

Section: Discussionmentioning

confidence: 97%

RETRACTED: A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing

Ali

Garg

Goyal

et al. 2020

Plants

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Treatment of wounds is essential as the wound can also be lethal at some point in time if not healed properly. Ethnomedicinal plants can treat wounds as they have no side effects, whereas, in the case of chemical drugs, the side effects are on the rise. In this study, seeds of Moringa oleifera which is the essential ethnomedicinal plant, were studied for wound healing efficacy. The study was planned for the assessment of in vitro (antioxidant and antimicrobial activities) and in vivo (excision and incision wound healing models) wound healing efficacy of n-hexane extract and hydrogels of Moringa oleifera seeds. The antioxidant and antimicrobial activities were assessed by DPPH free radical scavenging assay and Agar well diffusion method, respectively. In excision and incision wound models, Swiss albino mice were used for wound healing efficacy of hydrogels, i.e., 5% and 10% hexane extracts of Moringa oleifera seeds. The n-hexane extract showed antioxidant as well as antibacterial activities. Moreover, the hydrogels formulated using n-hexane extract of Moringa oleifera seeds showed significant wound healing activity compared to both control and standard until the end of the protocol in both the models. Furthermore, the histopathological investigation confirmed the findings of accelerated regeneration of tissue accompanied by a decrease in inflammatory cells and increased vascularity of the immediate skin. The results (both in vitro and in vivo) claimed conclusively that our n-hexane hydrogel formulation of Moringa oleifera seeds might serve as an alternative therapy in skin restoration during wound healing.

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Section: Discussionmentioning

confidence: 97%

RETRACTED: A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing

Ali

Garg

Goyal

et al. 2020

Plants

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“…The 1 H and 13 C NMR data of 3 (Table ) were similar to those of 2 except for some differences at the sugar part. The NOE correlations of H-3″/H-5″ and H-4″/6″-CH 3 (Figure ) and the coupling constants (Figure ) indicated that the sugar moiety in 3 was rhamnopyranosyl . The coupling constant (1.8 Hz) of H-1″ confirmed the rhamnopyranosyl as an α-glycosidic linkage …”

mentioning

confidence: 87%

Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation

Zhu

Mei

et al. 2014

Org. Lett.

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Inactivation of the O-methyltransferase gene crmM of Actinoalloteichus cyanogriseus WH1-2216-6 led to a mutant that produced three new acyclic bipyridine glycosides, cyanogrisides E-G (1-3). Further chemical analysis of the wild strain yielded 1 and another new analogue, cyanogriside H (4). Compounds 1-4 possess a skeleton consisting of a 2,2'-bipyridine and a d-quinovose or l-rhamnose sugar moiety. Cyanogriside G (3) was considered to be a key biosynthetic intermediate of the cyclic bipyridine glycosides cyanogrisides A-D. Compounds 2 and 3 showed cytotoxicities against HCT116 and HL-60 cells, and compounds 1 and 4 were cytotoxic on K562 cells.

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“…Meryer's reagent was added to one portion and Wagner's reagent to the other. The formation of a cream (with Meryer's reagent) or reddish brown precipitate (with Wagner's reagent) was taken as positive for the presence of alkaloids (Trease & Evans, 1989;Oluduro, 2012).…”

Section: Determination Of Alkaloidsmentioning

confidence: 99%

Phytochemical and Antimicrobial Properties of the Aqueous Ethanolic Extract of Saccharum officinarum (Sugarcane) Bark

Uchenna¹,

Adaeze²,

Steve³

2015

JAS

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Phytochemical analysis and antimicrobial activities of the aqueous ethanolic extract of Saccharum officinarum were carried out. The antimicrobial activity was screened by disc diffusion method while the analysis of the different phytochemicals was carried out using standard methods. The result showed that the extract had inhibitory effects on the gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa). The effect of the extract was minimal on Staphylococcus aureus, a gram positive bacteria suggesting some degree of resistance by the organism. The result of the phytochemical screening showed that extract contains saponins, tannins, flavonoids and reducing sugars. The findings show that the plant bark extract has bactericidal activity and could be used in the control and treatment of bacterial infection especially the gram negative bacteria.

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Evaluation of Antibacterial Potential of Crude Extract of Moringa oleifera seed on Orthopaedics Wound Isolates and Characterization of Phenylmethanamine and Benzyl Isothiocyanate Derivatives

Cited by 13 publications

References 9 publications

RETRACTED: A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing

RETRACTED: A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing

Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation

Phytochemical and Antimicrobial Properties of the Aqueous Ethanolic Extract of Saccharum officinarum (Sugarcane) Bark

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