Evaluation of antibacterial activity of Asparagus racemosus in urinary tract infection

Jose, Jinish; Devassykutty, Denny

doi:10.5455/njppp.2016.6.0617401072016

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…As many as 50-80% of women in the general population acquire at least one UTI during their lifetime because of short urethra and its proximity to vagina which acts as a reserver of microorganisms. [4,5] Acute uncomplicated cystitis may recur in 27-44% of healthy women, even though they have normal urinary tract. [6] Antimicrobial therapy is needed for any symptomatic UTI.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial prescribing pattern in urinary tract infection in a tertiary care hospital

Naik¹,

Samal²,

Sahu³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: Urinary tract infection (UTI) is a common illness affecting both males and females in almost all age groups. Varieties of antimicrobials such as cotrimoxazole, nitrofurantoin, fluoroquinolones, and penicillin are effective for treatment of UTI. Aims and Objectives: The present observational study was planned to generate data on antimicrobial use pattern in UTI which could be beneficial in selection of rational drug therapy in UTI. Materials and Methods: The retrospective study was carried out by analyzing indoor and outpatient department case records of UTI patients of a tertiary care hospital. The demographic data and prescription pattern, urine culture report, along with the antimicrobial sensitivity testing were evaluated. The data were analyzed by routine descriptive statistics. Results: Escherichia coli was the most common organism to be isolated in urine culture followed by Staphylococcus aureus. Cephalosporin group was the most prescribed antibiotics in all age groups. Although nitrofurantoin and cotrimoxazole were showing good sensitivity pattern when compared with other antimicrobial groups, these were least prescribed. Conclusion: The choice of antimicrobial drugs should be individualized based on patient compliance, adverse effects, availability and costing factors, along with prevailing sensitivity pattern in the locality. Nitrofurantoin can be better alternative for uncomplicated UTI when compared to third generation cephalosporins.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial prescribing pattern in urinary tract infection in a tertiary care hospital

Naik¹,

Samal²,

Sahu³

et al. 2017

Natl J Physiol Pharm Pharmacol

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show abstract

“…This drug is safe without any side effects. 14,15 Withenia somnifera is annual evergreen shrub belong to Solanaceae family commonly known as 'Ashwagandha' or 'Winter Cherry'. It is native of India, Asia and Africa.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of methanolic root extracts of and against uropathogens causing urinary tract infection

Bhonsle

Vyas²,

Vyas³

et al. 2022

IJCAAP

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Urinary tract infection is one of the most common bacterial disease found in all age groups and has become a major health problem in developing countries. UTI’s are treated with various antibiotics but extensive and inappropriate use of antibiotics promotes the development of antibiotic resistance among uropathogenic bacteria and also responsible for emerging multidrug resistant strains. The development of drug resistance among uropathogens made treatment of UTI is difficult which has led to the search of new source of antimicrobial agent that act against these uropathogenic bacteria. The ethnomedicinal plants are natural resource and known as traditional healer, which can use for successful therapy of various infectious diseases. In present study, we observed antibacterial potential of methanolic root extract of two medicinal plants and against urinary tract infection causing uropathogens. For this 120 urine samples of suspected patients were collected from different hospitals of Ujjain and processed in SRL laboratory Ujjain Center. It was seen that 72 samples were positive and showing significant bacteriuria and prevalence of UTI was 60%. The major causal bacterial agent was , and and their frequency of occurrence was 37.5%, 25%, 15.2%, 13.8% and 9.7%. The antibacterial effect of methanolic plant extracts of both and was determined against isolated uropathogens by disc diffusion method. The effectiveness of both and was observed and it was found that they have effective antibacterial activity against uropathogens so they can be used as alternative drug against uropathogens.

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“…Asparagus racemosus commonly called Shatavari is a climber plant widely grown all over India and its root are fleshy and tuberous. In herbal medicine, A. racemosus root is being used for the treatment of various ailments such as urinary tract infections, diarrhea, and dysentery because of its anti-microbial activity [4][5][6]. It is having good antibacterial activity against Gram-negative bacteria [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Oxytocic Activity of Asparagus Racemosus Jinish Jose Department of Pharmacology

Jose

2021

Asian J Pharm Clin Res

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Objective: The objective of the study was to evaluate the anti-oxytocic activity of ethanolic extract of Asparagus racemosus root. Methods: Ethanolic extract of A. racemosus root was taken by Soxhlet extraction method. Wistar strain albino non-pregnant female rats of weight 200–300 g were pre-treated with estrogen and were sacrificed to take their uterus. The tissue was then mounted in an organ bath containing de Jalon’s solution. The response of the tissue to various doses of oxytocin alone and then on adding increasing doses of the alcoholic extracts of A. racemosus along with the dose of oxytocin which produces sub-maximal contraction were recorded on a smoked drum. Results: Extract in doses up to 40 mg when given along with oxytocin 0.1 unit produced graded increase in contractions in rat uterus. From 80 mg onward graded blockade of contractions occurred with complete blockade at 200 mg. On complete removal of the extract by thorough washing, it was seen that oxytocin was again able to produce contractions of the rat uterus tissue. Conclusion: The ethanolic extract of A. racemosus root had demonstrated good anti-oxytocic property.

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Evaluation of antibacterial activity of Asparagus racemosus in urinary tract infection

Cited by 3 publications

References 8 publications

Antimicrobial prescribing pattern in urinary tract infection in a tertiary care hospital

Antimicrobial prescribing pattern in urinary tract infection in a tertiary care hospital

Antibacterial activity of methanolic root extracts of and against uropathogens causing urinary tract infection

Evaluation of Anti-Oxytocic Activity of Asparagus Racemosus Jinish Jose Department of Pharmacology

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