Evaluation of Anti-Toxoplasma gondii Antibodies in Hemodialysis Patients with Chronic Kidney Disease in Sari, Iran

Seyyedpour, Seyyed Hosein; Afshar, Parvaneh; Barzegarnejad, Ayoub; Kalhori, Shamsi; Agah, Reza

doi:10.5812/numonthly.40182

Cited by 4 publications

(6 citation statements)

References 15 publications

(22 reference statements)

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“…In the control group of 64.7%, person had IgG antibody against T. gondii, and 0.7% were positive for IgM. This study revealed a high prevalence of T. gondii infection in hemodialysis patients, which is similar to findings in Turkey (76.5%) [28] and Iran (80.8%) [29], but higher than other reported studies in Iran (60.0%), Malaysia (51%), Mexico (10.0%) and Egypt (60%) [1,[9][10][11]. The significant differences in prevalence between the regions might be attributed to the differences in socioeconomic, cultural (cat ownership, personal hygiene, feeding habits) and perhaps climatic factors [30,31].…”

Section: Discussionsupporting

confidence: 82%

“…The prevalence of anti-Toxoplasma IgG antibody is positively associated to the duration of hemodialysis treatment [28,33]. However, in the present study in north of Iran, there was no significant difference between the duration of dialysis and toxoplasmosis IgG antibody and this has been reported in other local studies too [29,36]. Besides, the prevalence of toxoplasmosis was significantly higher in females than in males in the current investigations (P = 0.005).…”

Section: Discussioncontrasting

confidence: 75%

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Seroepidemiology and Associated Risk Factors of Toxoplasma gondii in Hemodialysis Patients

et al. 2020

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Purpose Immunocompromised patients may be at risk for reactivation of the toxoplasmosis infection, because of defection in cell-mediated immunity. Therefore, early diagnosis would be highly desirable in these individuals. This case-control study was designed to increase information about toxoplasmosis in hemodialysis (HD) patients in Guilan province, Iran. Methods The study was performed among 150 patients and 150 controls referred to hospitals of Guilan University of Medical Sciences during 2018-2019. Questionnaire forms, including demographic and epidemiological information, were completed. Peripheral blood samples were taken for serum separation and were collected into tubes and then kept at − 20 °C until use. IgG and IgM antibodies to Toxoplasma gondii were detected by a commercial ELISA kit. Accordingly, IgG absorbance levels < 9 were considered negative, 9-11 was considered borderline, and > 11 was positive; IgM absorbance levels < 0.9 were considered negative, 0.9-1.1 was assumed to be borderline, and > 1.1 was positive. Results Throughout the study, 72.0% of HD patients and 64.7% of the control group were positive for anti-Toxoplasma IgG antibody subsequently. 2% of HD patients and 0.7% of the control group were positive for anti-Toxoplasma IgM antibody and these difference weren't significant between control and ones with HD (P > 0.05). There was no significant difference between dialysis duration factor and the seropositivity rate. Seroprevalence of T. gondii infection did not vary significantly with age, educational level, residence and presence of a cat at home. On the contrary, seroprevalence varied significantly with gender and consumption of raw vegetables. Conclusion Because of the high percentage of positivity for Toxoplasma IgG antibodies in hemodialysis patients, we suggest a periodically screening program to carry out for monitoring and evaluating the possible dissemination of toxoplasmosis during hemodialysis.

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Section: Discussionsupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 75%

Seroepidemiology and Associated Risk Factors of Toxoplasma gondii in Hemodialysis Patients

et al. 2020

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“…Of the 1,659 identified articles, 10 were included, and the results from these studies were weighted ( Table 1 ) [ 40 - 49 ]. One study was removed due to over-matching [ 50 ]. A flow diagram showing the study selection process is presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

Foroutan

Rostami²,

Majidiani

et al. 2018

Epidemiol Health

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OBJECTIVESToxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of Toxoplasma gondii among patients undergoing hemodialysis in Iran.METHODSWe searched English and Persian databases for studies reporting T. gondii seroprevalence in Iranian hemodialysis patients through December 31, 2017. Inclusion and exclusion criteria were applied.RESULTSA total of 10 studies containing 1,865 participants (1,048 patients and 817 controls) met the eligibility criteria. Immunoglobulin G (IgG) antibodies against T. gondii were found in 58% (95% confidence interval [CI], 46 to 70) of hemodialysis patients and 40% (95% CI, 31 to 50) of healthy controls, while immunoglobulin M (IgM) antibodies were found in 2% (95% CI, 0 to 6) of hemodialysis patients and 0% (95% CI, 0 to 1) of healthy controls. The meta-analysis showed that hemodialysis patients were significantly more likely to be seropositive for IgG (odds ratio [OR], 2.04; 95% CI, 1.54 to 2.70; p<0.001) and IgM (OR, 2.53; 95% CI, 1.23 to 5.22; p<0.001) antibodies against T. gondii infection than healthy individuals.CONCLUSIONSThe current study revealed a high prevalence of T. gondii infection in hemodialysis patients. Since hemodialysis patients are immunocompromised and T. gondii can cause serious clinical complications, we recommend that periodic screenings for T. gondii infection should be incorporated into the routine clinical care of these patients.

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“…The study of Forough Kazemi, [20] , Al-Saadawi and Alkhaled [21] , Ayser and Abdul-Aziz [22] Bayani,M [23] ,Al-Dulaimi [24], Sharif Maraghi [25], recorded similar results of our current study. On the other hand, there are studies that differ with it Seyyedpour [26]. Among the hemodialysis patients, the results showed that the percentage of seropositivity was higher in males 17(40.47) than in females 15 (45.45) but the differences were not statistically significant , Jones [27] .…”

Section: Discussionmentioning

confidence: 97%

Impact of Toxoplasmosis in Im-mune Respons in Hemodialysis Patients

Salem¹,

Shaker²,

Mohammed³

2022

DJM

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Background:Toxoplasma gondii is the most common infection of protozoa, affecting a wide range of hosts. Toxoplasmosis is usually asymptomatic in immu-nocompetent persons, but in immunocompromised persons (ex:patients on dialysis) significant problems can ensure, and may progress to a life-threatening infection. Objective: To investigate the seroprevalence of anti-Toxoplasma anti-bodies in patients undergoing hemodialysis in Baquba / Iraq . Patients and Methods: A group of blood samples, consisting of 75 dial-ysis patients and 50 healthy controls, were examined for the detection of anti-toxoplasma antibodies in Baquba Governorate from November 2020 to April 2021 using enzyme-linked immunosorbent assay (ELISA) for IgG and IgM. Results: The total numbers of the 125 samples were examined, 32 (44.0%) and 2 (4.0%) were IgG-positive for both patients and healthy individual respectively, and the results of the current study showed only 1 (1.33%) was seropositive IgM for patient group, while no seroposi-tive healthy subjects was found for IgM . The results showed that the percentage of seropositivity was higher in 17 males (40.47%) than in females 15 (45.45%) in the group of patients, but the differences were not statistically significant . As for the age groups, a positive increase was observed in the age group 11-30 years when comparing patients and healthy people, as the percentage reached 5 (29.41%). It was also ob-served that the highest seropositivity in the education levels was in the group of patients at the educational level 6-12 (45.45%) than in the healthy controls group, but the differences were not statistically signifi-cant between education levels. Patients living in urban areas had signifi-cantly higher serum (P = 0.0041) than patients in rural areas, and the odds ratio was 22,000. And those who had contact with cats showed a significant increase in seropositivity p = 0.0466 and odds ratio was 20.5789. Conclusion: Dialysis patients are at risk for toxoplasmosis and should be screened on a regular basis to prevent the disease from spreading dur-ing hemodialysis. Keywords: Toxoplasma gondii, Hemodialysis, Antibodies ,IgG

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Evaluation of Anti-Toxoplasma gondii Antibodies in Hemodialysis Patients with Chronic Kidney Disease in Sari, Iran

Cited by 4 publications

References 15 publications

Seroepidemiology and Associated Risk Factors of Toxoplasma gondii in Hemodialysis Patients

Seroepidemiology and Associated Risk Factors of Toxoplasma gondii in Hemodialysis Patients

A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

Impact of Toxoplasmosis in Im-mune Respons in Hemodialysis Patients

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