Evaluation of anti-inflammatory effect of derivative ( E )- N -(4-bromophenyl)-2-(thiophen-2-ylmethylene)-thiosemicarbazone

Oliveira, Jamerson Ferreira de; Nonato, Fabiana Regina; Zafred, Rafael Rosolen Teixeira; Leite, Nayara Maria Siqueira; Ruiz, Ana Lúcia Tasca Góis; Carvalho, João Ernesto de; Silva, Anekécia Lauro da; Moura, Ricardo Olímpio de; Lima, Maria do Carmo Alves de

doi:10.1016/j.biopha.2016.03.047

Cited by 19 publications

(9 citation statements)

References 27 publications

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“…The hind paw volume was evaluated using a plethysmometer at 0 (basal volume), 1, 2, 4, 6, and 24 h after CG inoculation, and the edema volume was obtained by the difference between basal and experimental hind paw volumes. The procedures used for this study were similar to those described previously, with minor modifications [10,36]. ▶Table 4 Group distribution in the croton oil-induced ear edema assay in mice.…”

Section: Carrageenan-induced Paw Edemamentioning

confidence: 99%

“…One hour after each treatment, mice received croton oil topical application (20 µL/ear, 5 % in acetone 70 %) in the right ear, while the left ear was treated with 70 % acetone (20 µL/ear). Four hours after croton oil application, the animals were euthanized, and the ear edema was determined by weight difference between the left and right ears [36].…”

Section: Croton Oil-induced Ear Edemamentioning

confidence: 99%

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An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

Paiva

Nonato

Ruiz

et al. 2020

PMIO

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The tumor microenvironment presents several therapeutic targets, with inflammation being one of them. In search of new drugs, plants have shown to be an effective source of potent anti-inflammatory and anticancer agents. This study aimed to evaluate the antitumoral and inflammatory activities of Boehmeria caudata aerial parts extract. Bioguided in vitro antiproliferative screening showed that phenanthroquinolizidine obtained from the aerial B. caudata ethanolic extract had a straight relationship with activity. Moreover, the orally administered ethanolic extract reduced Ehrlich solid tumor growth and displayed an anti-inflammatory effect in both evaluated experimental models (carrageenan-induced paw edema and croton oil-induced ear edema). These results suggest that the antitumor activity of the ethanolic extract could be explained by antiproliferative effects associated with anti-inflammatory action.

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Section: Carrageenan-induced Paw Edemamentioning

confidence: 99%

Section: Croton Oil-induced Ear Edemamentioning

confidence: 99%

An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

Paiva

Nonato

Ruiz

et al. 2020

PMIO

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“…These antinociception results corroborate the data obtained in the evaluation of the anti-inflammatory activity presented by COPHCT, since this compound seems to act in the inflammatory phase of pain. However, another study with thiosemicarbazone revealed activity in both phases of inflammation induced by carrageenan, suggesting an action in the early mediators of inflammation or through inhibition of pro-inflammatory cytokines (6).…”

Section: Discussionmentioning

confidence: 97%

“…On the other hand, pain is a characteristic of inflammation, and therapeutic approaches to pain relief are based on non-steroidal or opioid anti-inflammatory drugs. The inevitable undesirable effects associated with the misuse of these classes of drugs have led to the research and development of newer, safer, and more efficient therapeutic agents, presenting little or no side effect in the control of pain (5,6).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antinociceptive effects of the isatin derivative (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-phenyl-hydrazinecarbothioamide in mice

Dantas

Fonseca

Pereira

et al. 2020

Braz J Med Biol Res

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Several isatin derivatives have shown important biological activities, which have attracted interest from researchers. For this reason, the present study aimed to evaluate the anti-inflammatory and antinociceptive effects of the isatin derivative (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-phenyl-hydrazinecarbothioamide (COPHCT) in mice. Three doses of this compound were tested: 1.0, 2.5, and 5.0 mg/kg. The anti-inflammatory activity was assessed using the carrageenan-induced paw edema model and the zymosan-induced air pouch model. The evaluation of the antinociceptive effect was performed through the formalin test and the acetic acid-induced abdominal writhing test. The paw edema assay demonstrated that all doses of the compound showed a significant reduction of the edema in the second hour evaluated, but a better response was observed in the fourth hour. The zymosan-induced air pouch model indicated that the compound, in all doses, significantly reduced leukocyte migration and total protein concentration levels. In the formalin test, the doses 1.0, 2.5, and 5.0 mg/kg of COPHCT showed activity only in the second phase, with reduction in paw pain time of 73.61, 79.46, and 73.85%, respectively. The number of abdominal writhings decreased with the increasing dose, but only 5.0 mg/kg COPHCT exhibited a significant response, with a reduction of 24.88%. These results demonstrated the ability of this compound to interfere in the anti-inflammatory activity of edema, vascular permeability, and cell migration. In addition, its possible antinociceptive effect may be related to the dose used.

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“…The biological importance of these Schiff's base chelates of thiosemicabazides involved the researchers greater than before to develop fresh ligands as antibacterial [16], antimicrobial [17][18][19], antifungal [20,21], antiparasitic [22], antitumor [23], anticancer [24][25][26], antioxidant [27,28], anti-inflammatory [29], anti-HIV [30], antiproliferative [31], antileishmanial activities [32] and antiviral [33]. Tetradentate thiosemicabazone with strong DNA-binding ability was isolated after the condensation of pyruvaldehyde with 4-(aryl)-thiosemicarbazones [34].…”

Section: Biological Importance Of Semicarbazones and Thiosemicarbazonesmentioning

confidence: 99%

Biological Applications of Co(II) and Ni(II) Complexes of Semicarbazones and Thiosemicarbazones

Jain¹,

Kumar²,

Chandra³

2018

Asian J. Chem.

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Evaluation of anti-inflammatory effect of derivative ( E )- N -(4-bromophenyl)-2-(thiophen-2-ylmethylene)-thiosemicarbazone

Cited by 19 publications

References 27 publications

An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

Anti-inflammatory and antinociceptive effects of the isatin derivative (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-phenyl-hydrazinecarbothioamide in mice

Biological Applications of Co(II) and Ni(II) Complexes of Semicarbazones and Thiosemicarbazones

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