Evaluation of anti-inflammatory and radical scavenging activity of an aqueous extract of Barleria cristata leaves

Gambhire, M; Juvekar, M; Juvekar, Archana R.; Wankhede, Sachin V.; Sakat, S

doi:10.1055/s-0029-1234971

Cited by 19 publications

(23 citation statements)

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“…[1,20]. Some researchers have highlighted the use of EOs due to their beneficial effects in aromatherapy for their relaxing, sedative and, anti-inflammatory properties [29,30]. Concluding, according to our results, the EO of L. luisieri from Alentejo, which presents important antioxidant, antimicrobial, analgesic, and anti-inflammatory activities, is a promising candidate to be used as a food supplement or in pharmaceutical applications.…”

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confidence: 62%

Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. luisieri

et al. 2016

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The present study was carried out to evaluate the chemical and pharmacological properties of the essential oil of Lavandula stoechas subsp. luisieri, which is a spontaneous shrub widespread in Alentejo (Portugal). Oxygenated monoterpenes, such as 1,8-cineole, lavandulol, and necrodane derivatives, are the main components of essential oil. It revealed important antioxidant activity with a high ability to inhibit lipid peroxidation and showed an outstanding effect against a wide spectrum of microorganisms, such as gram-positive and gram-negative bacteria and pathogenic yeasts. The analgesic effect studied in rats was dose dependent, reaching a maximum of 67 % at 60 min with the dose of 200 mg/kg and the anti-inflammatory activity with this dose caused an inhibition in carrageenan-induced rat paw oedema (83 %) that is higher than dexamethasone 1 mg/Kg (69 %). Besides, animals exhibited normal behaviour after essential oil administration, revealing low toxicity. The essential oil of L. luisieri from Alentejo presents important pharmacological properties and low toxicity, and is a promised candidate to be used as a food supplement or in pharmaceutical applications.

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confidence: 62%

Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. luisieri

et al. 2016

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“…It is generated by the activation of iNOS enzyme induced by inflammation. Plant extracts with the ability to regulate iNOS and COX-II also have anti-inflammatory actions [24][25][26]. In the present study, it has been shown that the Codonopsis pilosula extract significantly reduces the concentration of NO generated by LPS in the Raw cells and shows strong inhibition of iNOS expression.…”

Section: Discussionmentioning

confidence: 53%

Methanol Extract of <i>Codonopsis pilosula</i> Inhibits Inducible Nitric Oxide Synthase and Protein Oxidation in Lipopolysaccharide-Stimulated Raw Cells

Yoo¹,

Kim²

2013

Trop. J. Pharm Res

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Purpose: To evaluate the mechanism of antioxidant activity of the methanol extract of Codonopsis pilosula. (p < 0.05) Methods: Anti-oxidative properties were assessed by measuring free radical scavenging activity, nitric oxide (NO) levels, protein oxidation and reducing power, while the mechanism of antioxidative effect of Codonopsis pilosula extract was determined by measuring iNOS and COX-2 expression in lipopolysaccharide (LPS)-stimulated raw cells. Results: Codonopsis pilosula extract (CPE) exerted significant DPPH free radical and NO-scavenging activities. Protein oxidation was decreased by 30 % by the CPE (1mg/ml). The extract (1mg/ml) enhanced reducing power 16-fold (compared with control). LPS-induced production of iNOS was significantly inhibited by the extract (60 %), suggesting that it inhibits NO production by suppressing iNOS expression. However, LPS-induced production of COX-2 was not significantly

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“…Barleria cristata Linn. (Acanthaceae) is employed traditionally to treat inflammatory disorders, toothache, anemia, fever, bronchitis, pains, swelling, blood diseases, coughing, and asthma [29,30]. Karan et al [28] isolated three iridoids, i.e., barlerin (32), acetyl barlerin (33), and shanzhiside methyl ester (34), from B. cristata, and found that the three metabolites possess potent anti-inflammatory effects.…”

Section: Iridoid Derivatives As Anti-inflammatory Agentsmentioning

confidence: 99%

Therapeutic Potential of Iridoid Derivatives: Patent Review

et al. 2019

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Iridoids belong to a family of monoterpenoids comprising the cyclopentan[c]-pyran system; this class of compounds offers a wide range of biological effects, namely antileishmanial, anticancer, antiplasmodial, and anti-inflammatory potency. To date, a large number of biologically active iridoid derivatives have been reported from various plant families, including Rubiaceae, Plantaginaceae, Scrophulariaceae, and Verbenaceae. Furthermore, iridoids have the potential to form conjugates with other anticancer, antidiabetic, antileishmanial, and antimalarial drugs which synergistically have the potential to increase their effects. Additionally, future research should focus on the synthesis of halo analogs as well as preparing homo dimers or heterodimers of iridoids, since these might quite conceivably possess an increased bioactivity.

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Evaluation of anti-inflammatory and radical scavenging activity of an aqueous extract of Barleria cristata leaves

Cited by 19 publications

References 0 publications

Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. luisieri

Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. luisieri

Methanol Extract of <i>Codonopsis pilosula</i> Inhibits Inducible Nitric Oxide Synthase and Protein Oxidation in Lipopolysaccharide-Stimulated Raw Cells

Therapeutic Potential of Iridoid Derivatives: Patent Review

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