Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. luisieri

Abstract

The present study was carried out to evaluate the chemical and pharmacological properties of the essential oil of Lavandula stoechas subsp. luisieri, which is a spontaneous shrub widespread in Alentejo (Portugal). Oxygenated monoterpenes, such as 1,8-cineole, lavandulol, and necrodane derivatives, are the main components of essential oil. It revealed important antioxidant activity with a high ability to inhibit lipid peroxidation and showed an outstanding effect against a wide spectrum of microorganisms, such as gram-positive and gram-negative bacteria and pathogenic yeasts. The analgesic effect studied in rats was dose dependent, reaching a maximum of 67 % at 60 min with the dose of 200 mg/kg and the anti-inflammatory activity with this dose caused an inhibition in carrageenan-induced rat paw oedema (83 %) that is higher than dexamethasone 1 mg/Kg (69 %). Besides, animals exhibited normal behaviour after essential oil administration, revealing low toxicity. The essential oil of L. luisieri from Alentejo presents important pharmacological properties and low toxicity, and is a promised candidate to be used as a food supplement or in pharmaceutical applications.

Antimicrobial Activity of Essential Oils of Lamiaceae Aromatic Spices Towards Sheep mastitis-Causing Staphylococcus aureus and Staphylococcus epidermidis

“…A study of Lai et al 21 , in which different organic extracts from Portuguese plants were evaluated for their antimicrobial potential, highlights L. luisieri extracts MIC values ranging between 15 and 250 μg mL -1 for S. aureus and 62 and 250 μg mL -1 for S. epidermidis. Arantes et al 22 reported the high activity of L. luisieri EO against a wide spectrum of microorganisms, such as Gram-positive and Gram-negative bacteria, with MIC values ranging between 150 and 1,000 μg mL -1 .…”

Integrative Analysis of Vaginal Microorganisms and Serum Metabolomics in Rats With Estrous Cycle Disorder Induced by Long-Term Heat Exposure Based on 16S rDNA Gene Sequencing and LC/MS-Based Metabolomics

“…Among the metabolites with decreased levels, lavandulol has an antimicrobial effect on bacteria and a significant antioxidant effect on multifarious microorganisms (Arantes et al, 2016). The mechanism of action consists of disturbing the lipid structure of cell membranes, thereby leading to cell death (Bialon et al, 2019).…”

Supercritical Carbon Dioxide Antisolvent Fractionation for the Sustainable Concentration of Lavandula luisieri (Rozeira) Riv.- Mart Antimicrobial and Antioxidant Compounds and Comparison with Its Conventional Extracts

“…These constituents have only been previously found in the defensive secretions of the beetle Necrodes surinamensis and in the sexual pheromone of the grape mealybug Pseudococcus maritimus [10]. The potential bioactivity of this particular plant species has been focused so far on its essential oil, for which several bioactivities have been reported; antioxidant [11,12,13]; antimicrobial [6,13,14,15,16,17] antifeedant [7,8]; ixodicidal [18]; antiparasitic [19]; and antiinflamatory [13,20]. However, information about other L. luiseri extracts is scarce.…”