Evaluation of anti-inflammatory and antinociceptive activities of some Onosma L. species growing in Turkey

Tosun, Alev; Akkol, Esra Küpeli; Bahadır, Özlem; Yeşilada, Erdem

doi:10.1016/j.jep.2008.09.007

Cited by 33 publications

(20 citation statements)

References 23 publications

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“…It has been reported that Borage (Borago officinalis L.) was useful for its antipyretic, antihypertensive, antispasmodic, aphrodisiac and diuretic properties [4,5] . Previous findings showed that some species of Boraginaceae were used for the treatment of hemorrhoids [6] . Furthermore, it has also been observed that various parts of Echium species could be used for their antiinflammatory, antibacterial, antidepressant, antiproliferative, antiviral, antioxidant, cytotoxic and anxiolytic properties [2,3] .…”

Section: Abstract: Echium Italicum L Anchusa Arvensis L Trichodementioning

confidence: 99%

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Faezizadeh¹,

Ghorbanihaghjo²,

Godarzee³

2016

ijps

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Faezizadeh, et al.: Antiglycation Effects of Some Boraginaceae SpeciesNon-enzymatic glycation of proteins is the major cause of diabetic complications and therefore, inhibition of this reaction could reduce the morbidity of this disease. The aim of this study was to evaluate the in vitro effects of aqueous and hydroethanol extracts of Echium italicum L., Anchusa arvensis L. and Trichodesma incanum (Bunge) A. DC. of Boraginaceae on albumin, hemoglobin, and crystalline glycation reaction. The results showed that the hydroethanol extract of Echium italicum in the concentrations of 100, 50 and 10 mg/dl could reduce the rate of albumin glycation to 85.10±1.85, 64.14±1.12 and 40.13±1.17%, respectively, and also in the same conditions, rates of hemoglobin glycation were reduced to 69.20±1.71, 46.13±1.93 and 27.73±0.90%, respectively. Moreover, extracts of three tested plants have antiglycation effects on crystalline glycation reaction. Under the identical conditions, the inhibitory effects of hydroethanol extracts of Echium italicum on the albumin, hemoglobin, and crystalline glycation reaction were higher than other extracts. The findings showed that the extracts of tested species, particularly in the hydroethanol form, could be used to prevent and treat complications of diabetes mellitus. Key words: Echium italicum L., Anchusa arvensis L., Trichodesma incanum (Bunge) A. DC., albumin, hemoglobin, glycationMembers of the family Boraginaceae include herbs, shrubs and trees totaling about 146 genera and 2000 species in the worldwide [1] . Some of these plants grow in Iran and used widely in Iran's folk medicine [2,3] . It has been reported that Borage (Borago officinalis L.) was useful for its antipyretic, antihypertensive, antispasmodic, aphrodisiac and diuretic properties [4,5] . Previous findings showed that some species of Boraginaceae were used for the treatment of hemorrhoids [6] . Furthermore, it has also been observed that various parts of Echium species could be used for their antiinflammatory, antibacterial, antidepressant, antiproliferative, antiviral, antioxidant, cytotoxic and anxiolytic properties [2,3] . Cyanidin, a natural phenolic compound is present in many kinds of plants, such as grapes, pomegranate and some species of Boraginaceae and according to the previous reports, this effective compound has antioxidant and antidiabetic potential [7][8][9][10] .Diabetes mellitus is a common endocrine disease and a leading cause of morbidity and mortality in the world [11] . In this disease, the macro and microvascular complications lead to severe effects on the eyes, central nervous systems and kidneys [12] . Evidence from in vitro and in vivo experiments indicated that diabetic hyperglycemia could increase the risk of complications [13,14] . It seems that non-enzymatic glycation plays an important role in progression of diabetic complications [11] . Due to prolonged hyperglycemia, the non-enzymatic glycation of proteins could significantly change their structural and functional properties [12] . Previous studie...

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Section: Abstract: Echium Italicum L Anchusa Arvensis L Trichodementioning

confidence: 99%

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Faezizadeh¹,

Ghorbanihaghjo²,

Godarzee³

2016

ijps

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“…Many species of the Onosma L. have been used in ethnopharmacology and the ethanol extract of some species has been reported to have anti-inflammatory and analgesic properties. Some are used for other health remedies, treatment of wounds, as herb, traditional medicine and dyes (Özgen et al, 2003;2004;Naz et al, 2006;Tosun et al, 2008, Kumar et al, 2013Daironas et al, 2014;Imran et al, 2018). The floral parts of some species are edible and taken as vegetables (Öztürk & Özçelik, 1991).…”

Section: Introductionmentioning

confidence: 99%

Pollen morphology and systematic significance of some Onosma L. species (Boraginaceae) distributed in pan Himalayan regions

Mazari¹,

Liu²

2019

PAK.J.BOT.

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The pollen morphology of 15 Onosma L. species has been examined by SEM for the first time from Pan Himalayan regions of Pakistan and China. Generally, the pollen grains are single, isocolpate, radially symmetrical, isopolar or heteropolar, 3-colporate or 3syncolporate, small to medium in size. The mean polar axis ranged from 10.00-25.43 µm long while the equatorial diameter ranged from 8.68-16.93 µm. The mean P/E ratio generally ranged from 1.04-1.56 µm. On the basis of P/E ratio, three pollen shapes have been recognized (prolate spheroidal, subprolate and prolate). Ornamented aperture membrane and lolongate ora uniformly observed among all studied taxa. However, the results show great diversity within species in regard of polarity, apertures and exine ornamentation (spinulose, rugulate, rugulate-echinate, rugulate to granulate). On the basis of aperture type, two basic pollen types have been recognized. Type-I 3-syncolporate observed in five species (O. confertum, O.

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“…This plant is also used in the treatment of diseases such as eye diseases, blood disorders, bronchitis, stomachache, and against disturbances such as inflammation, rash, fever, scar, hemorrhoid and kidney stone (26).…”

Section: Introductionmentioning

confidence: 99%

“…This study intended to examine the effect of Onosma nigricaule, which is reported to be protective and therapeutic (4,26), on the changes caused by malathion that is among organophosphorus pesticides, in the renal tissue and immunohistochemical oscillation of CAT and Mn-SOD that are among antioxidant enzymes. The discovery of antioxidant features of Onosma nigricaule against the oxidant features of malathion, presence of the protective effects of this plant against pharmacological effects and possible damages of pesticides, and the opinion that it would lead new alternative ways in the field of medicine and pharmaceutical industry form the basis of this study.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical examination on the effects of malathion and Onosma nigricaule (Boraginaceae) on the catalase (CAT) and superoxide dismutase-2 (Mn-SOD) in renal tissues of mice

ERDAĞ¹

2017

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:The purpose of this study was to determine the effects of the plant extract, which is obtained from Onosma nigricaule due to the oxidation parameters caused in mice by malathion that is used as an insecticide in agriculture, on catalase (CAT) and superoxide dismutase-2 (Mn-SOD) in kidney tissues by immunohistochemical technique. A total of 48 male mice (Mus musculus) were used in our study. Mice were divided 6 groups (control group, maize oil group, normal saline group, Onosma nigricaule group, malathion group, Onosma nigrcaule+malathion group). Hematoxylin-eosin and triple staining methods were used for histological and pathological examinations. The localization of CAT and Mn-SOD in the renal tissue was determined using the method of streptavidinbiotin-peroxidase. CAT immunoreactivity was determined with a weak intensity in epithelium of renal tubulus proximalis of mice in the malathion group, with a moderate intensity in Onosma nigricaule+malathion group and with a higher intensity in tubulus proximalis of other groups. A cytoplasmic Mn-SOD immunoreactivity was determined with weak intensity in renal medulla of mice in malathion group, with moderate intensity in renal medulla of mice in Onosma nigricaule plant extract+malathion group, maize oil group, and normal saline group and with highly intensity in control and Onosma nigricaule groups. It was concluded that Onosma nigricaule might play a protective role as an antioxidant against the oxidant features of malathion.Keywords: Catalase, kidney, malathion, mice, Onosma nigricaule, superoxide dismutase. Malathion ve Onosma nigricaule (Boraginaceae)'nin fare böbrek dokusunda katalaz (CAT) ve süperoksit dismutaz-2 (Mn-SOD) salınımı üzerine etkileriÖzet: Bu çalışmada, tarımda insektisit olarak kullanılan ve farelerde oksidasyon parametrelerine neden olan malathiona karşıOnosma nigricaule'den elde edilen bitki ekstraktlarının immunohistokimyasal yöntemle böbrek dokusunda katalaz (CAT) ve süperoksit dismutaz-2 (Mn-SOD) salınımı üzerine etkilerinin saptanması amaçlanmıştır. Çalışmamızda 48 adet erkek (Mus musculus) fare kullanıldı. Fareler 6 gruba (kontrol grubu, mısır yağı grubu, serum fizyolojik grup, Onosma nigricaule grubu, malathion grubu, Onosma nigricaule+malathion grubu) ayrıldı. Histolojik ve patolojik değerlendirmeler için hematoksilen-eozin and triple boyama yöntemleri kullanıldı. Böbrek dokusunda CAT ve Mn-SOD lokalizasyonu için ise streptavidin-biotin-peroxidase yöntemi kullanıldı. CAT immunoreaktivitesinin fare böbrek dokusunun tubulus proksimalisinde olduğu görüldü. CAT immunoreaktivitesinin malathion grubunda zayıf, malathion+Onosma nigricaule grubunda orta yoğunlukta, diğer gruplarda ise yüksek yoğunlukta olduğu tespit edildi. Mn-SOD immunoreaktivitesinin böbrek medullasında olduğu görüldü. Malathion grubunda zayıf, mısır yağı grubu, serum fizyolojik ve Onosma nigricaule+malathion gruplarında orta yoğunlukta, kontrol ve Onosma nigricaule gruplarında ise yüksek yoğunlukta olduğu tespit edildi. Onosma nigricaule'nin malathionun oksidadif etkile...

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Evaluation of anti-inflammatory and antinociceptive activities of some Onosma L. species growing in Turkey

Cited by 33 publications

References 23 publications

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Pollen morphology and systematic significance of some Onosma L. species (Boraginaceae) distributed in pan Himalayan regions

Immunohistochemical examination on the effects of malathion and Onosma nigricaule (Boraginaceae) on the catalase (CAT) and superoxide dismutase-2 (Mn-SOD) in renal tissues of mice

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