Evaluation of anti-inflammatory and analgesic effects on the extracts of different parts of Excoecaria agallocha L.

Abstract

Scientific evaluated that, anti-inflammatory and analgesic activity of ethanol with water in the ratio of 3:1 extracts were obtained from different parts viz., leaves, seeds and latex of Excoecaria agallocha. The latex was sequentially soxhlated with petroleum ether and methanol dried latex in anti-inflammatory processes and analgesic activity in two concentrations (250 mg/kg and 500 mg/kg). Preliminary phytochemical analysis showed that, presence of alkaloids, flavanoids, saponins were found maximum in the seed extract. Acute inflammatory studies showed that, latex, leaves and seed extracts of both concentration of chosen plant produced significant inhibition of carrageenin induced rat paw edema at 3 rd hour (p<0.005) as compared to the control causing 63.15%, 62.15% and 69.69% respectively. In addition that, the seed extract at the concentration of 500 mg/kg showed maximum inhibition at 57.03% as compared to control in cotton pellet induced granuloma test. The analgesic activity of seed extract at the dose of 500 mg/kg. caused significant inhibitions in the acetic acid induced writhing. Moreover, the tail immersion model, seed extract at the concentration of 500 mg/kg. possess an maximum activity (80.29%) as compared to control.

Comparative Studies on Antioxidant and Anti-Inflammatory Activities of Ethanolic Extracts of True Mangrove and Mangrove Associate Located in Bhatye Beach Areas of Maharashtra, India

“…The phytochemical analysis have shown presence of most of these principles in the selected mangrove species, it differentiate in quality and quantity. In this study we examined total phenolics and flavonoids which were in accordance with other species of mangroves like Ceriops decandra and Bruguiera cylindrica L 23. The antioxidant potential of these selected mangrove species are in accordance with the presence of phytoconstituents responsible for antioxidant properties 24. A few mangroves species have shown antioxidant 25 and in-vivo anti-inflammatory properties 26. The extracts of ethyl acetate and water showed antioxidant activity in leaves, trunk and bark of S.alba species 27.…”

Methanol extracts of Xanthium sibiricum roots inhibit inflammatory responses via the inhibition of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) in murine macrophages

“…2 and 3). This difference may be explained by the fact that, in several cases, extracts from the different parts of the same plant lead to different pharmacological responses (Babuselvam et al, 2012;Dubey et al, 2013).…”

A complete profile on blind-your-eye mangrove Excoecaria agallocha L. (Euphorbiaceae): Ethnobotany, phytochemistry, and pharmacological aspects

“…Whereas in cotton pellet-induced granuloma test, the seed extract showed maximum activity at the dose of 500 mg/kg which was 57.03% compared to control. [66]…”

“…Moreover, in the tail immersion model, the seed extract at the concentration of 500 mg/kg possesses maximum activity (80.29%) as compared to control. [66] Crude alcoholic bark extract at 300 mg/kg dose showed maximum time needed for the response against thermal stimuli 6.72 ± 0.43 s compared to diclofenac sodium 8.20 ± 0.21 s in the hot plate test. In acetic acid-induced Writhings test in mice, 500 mg/kg dose of the bark extract showed maximum reduction (53.87%).…”