Evaluation of anti-inflammatory activity of Nigella sativa: An experimental study

Pise, Harshal N; Padwal, Sudhir L.

doi:10.5455/njppp.2017.7.0204705032017

Cited by 29 publications

(31 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When anti-LOX and cyclooxygenase activities were estimated, it was found maximum at 500 µg/mL of concentration in methanolic extract of N. sativa seeds and its seeds oil. The results were in accordance to the report of Pise and Padwal [34] for anti-LOX and cyclooxygenase activities where N. sativa exhibited anti-inflammatory activity in acute inflammation, i.e., carrageenan-induced paw edema in rats, which was also observed statistically significant (P < 0.001). At present, some investigations recommend that N. sativa inhibits eicosanoid production in lipid peroxidation and leukocytes.…”

Section: Discussionsupporting

confidence: 91%

Untitled

Ansari¹

2019

IJGP

View full text Add to dashboard Cite

Objective: The purpose of the current work is to elucidate the therapeutic property of Nigella sativa seeds (methanolic extract and seeds oil). The extent of activity and correlation has been studied. Materials and Methods: N. sativa seeds used to prepare methanolic extract and its oil are used to investigate in vitro anti-inflammation and total antioxidative property. Results: The analysis revealed that protein (albumin) denaturation was inhibited maximum in seeds oil of N. sativa with 82.966 ± 3.704%. Proteinase inhibitory action of seeds oil showed significant action and was found to be maximum with 39.623 ± 5.820%. Heat-induced hemolysis of erythrocytes showed that it was found maximum inhibition with 65.866 ± 3.066% while hypotonicity-induced hemolysis activity was done that it was found maximum inhibition with 69.109 ± 3.054%. When anti-lipoxygenase and cyclooxygenase activities were estimated, it was found maximum in seeds oil with 83.383 ± 3.294% and 64.863 ± 4.029%, respectively. When antioxidant activity was observed, it was found maximum in oil with 85.201 ± 4.235%. When two-way ANOVA was applied between various parameters, it was found significant with P < 0.05. However, when correlation was established between various anti-inflammatory and antioxidant activities, a strong positive correlation of 0.9 was obtained. Conclusion: An overall strong positive correlation between anti-inflammatory and antioxidative property was found, signifying that the antioxidative property of N. sativa might be accountable for its anti-inflammatory action. Further, it was found that its seeds oil holds better quantity and types of phytochemicals which possess significant anti-inflammatory and antioxidative property. Thus, more efforts are desirable to effusively elucidate the antioxidants accountable for its anti-inflammation action, therefore, to develop improved herbal drug formulations.

show abstract

Section: Discussionsupporting

confidence: 91%

Untitled

Ansari¹

2019

IJGP

View full text Add to dashboard Cite

show abstract

“…Topical Nigella sativa balm activity shows comparable results to Pise and Padwal (2017) research [16], where Nigella sativa oil with a dose of 10 ml/kg rats BW p.o showed a 39.64% oedema inhibition. These results indicate that the anti-inflammatory activity of Nigella sativa is clear whether it is given topically or orally.…”

Section: Discussionsupporting

confidence: 74%

“…The procedure of carrageenan-induced paw oedema in accordance with Pise and Padwal (2017) [16] with modification. The right foot of the rat was measured using a plethysmometer, then recorded as the initial volume (Vo).…”

Section: Acute Anti-inflammatory Test (Carrageenan-induced Paw Oedema)mentioning

confidence: 99%

The Anti-Inflammatory Activity of Nigella sativa Balm Sticks

2019

View full text Add to dashboard Cite

Nigella sativa oil has been known to have potent anti-inflammatory activity. This research aimed to determine the anti-inflammation activity of Nigella sativa oil in a simple balm stick by topical application. The activity was checked using two methods: carrageenan-induced paw oedema and granuloma pouch on rats. The results showed that balm sticks which contained 10% Nigella sativa could overcome both acute and sub-acute inflammation showing by high oedema inhibition (60.64%), low leucocytes count (43.55% lower than control) as well as a notable TNF-α concentration (50% lower than control) on the inflamed area. In conclusion, topical application of a Nigella sativa balm stick was effective for both acute and sub-acute forms of inflammation.

show abstract

“…Inflammation is a primary physiological mechanism, a normal defense mechanism that aims to help the organism to fight against initial injury such as that caused by allergens, microorganisms, or mechanical or chemical injury and its consequences, including pain [ 1 , 2 ]. An uncontrolled inflammatory process can induce prolonged chronic inflammation, which, most of the time, acts as an etiologic factor in the development of different chronic diseases [ 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Nigella Sativa’s Anti-Inflammatory and Antioxidative Effects in Experimental Inflammation

et al. 2020

View full text Add to dashboard Cite

Nigella sativa (NS) has been used for centuries in various inflammatory conditions because of its anti-inflammatory and antioxidant activities. The study aimed to evaluate the anti-inflammatory, antinociceptive and antioxidant activity of Nigella sativa oil (NSO) in two models of acute (carrageenan-induced) and sub-acute inflammation (complete Freund’s adjuvant induced) in rats. Materials and Methods: NSO was administered orally 1, 2 and 4 mL/kg in the acute phase. For subacute phase, NSO was administered 4 mL/kg, 7 days before or after inflammation induction, or in association with diclofenac 5 mg/kg. Results: The gas chromatography coupled with mass spectroscopy (GC-MS) analysis showed that NSO is an important source of bioactive compounds, especially p-cymene and thymoquinone. In the acute phase, 1.5 h after administration, NSO (2 and 4 mL/kg) determined an anti-inflammatory effect comparable with that of diclofenac. In the sub-acute administration, NSO had no anti-inflammatory effect. The analgesic effect of NSO was observed only in the sub-acute inflammation in the analgesy-meter test. NSO as treatment proved its antioxidant effect through the reduction of malondialdehyde (MDA) and oxidized glutathione (GSSG), and increases in hydrogen donor capacity (DH) compared to the control group, but the effect was not as intense as that of diclofenac. Conclusion: The present study has proven inconstant anti-inflammatory, analgesic and antioxidative properties of NSO.

show abstract

Evaluation of anti-inflammatory activity of Nigella sativa: An experimental study

Cited by 29 publications

References 9 publications

Untitled

Untitled

The Anti-Inflammatory Activity of Nigella sativa Balm Sticks

Nigella Sativa’s Anti-Inflammatory and Antioxidative Effects in Experimental Inflammation

Contact Info

Product

Resources

About