Evaluation of Anterior Segment Parameters in Pseudoexfoliative Glaucoma, Primary Angle-Closure Glaucoma, and Healthy Eyes

Aksoy, Nilgün Özkan; Çakır, Burçin; Doğan, Emine; Alagöz, Gürsoy

doi:10.4274/tjo.03271

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…However, Krysik, for instance, found CCT to be thicker in the PEX group [ 45 ]. Many other authors reported that there was no significant difference in CCT between the PEX and non-PEX groups [ 10 , 41 , 42 , 46 – 48 ]. Again, a large enough cohort might provide an answer to these conflicting data.…”

Section: Discussionmentioning

confidence: 99%

Exploring association between pseudoexfoliation syndrome and ocular aging

et al. 2022

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Purpose Within a population-based follow-up study, to examine the 10-year incidence of pseudoexfoliation syndrome (PEX), possible risk factors for PEX and its association with ocular aging of the cornea, lens and retina. Methods The baseline examination was conducted in 2006 on a random sample of 1,033 adult participants from Kaunas city (Lithuania) population of whom 631 had ophthalmic examination data at attendance of the 10-year follow-up in 2016. Detailed examination of the anterior and posterior segment of the eye was carried out. After diagnostic mydriasis PEX was diagnosed by the presence of typical grayish-white exfoliation material on the anterior capsule surface of the lens. The participants were divided to PEX and non-PEX groups. Results PEX prevalence increased from 9.8 to 34.2% from baseline to 10-year follow-up. Nuclear cataract was common both in the PEX group (66.7%) and in those without PEX (72.2%), but this difference did not reach statistically significantly increased risk of developing cataract in those with PEX (OR 1.2; p = 0.61). Central corneal thickness (CCT) was thinner in the PEX group (529 ± 34 μm) and in the oldest group (525 ± 36 μm) (p < 0.001). Compared to baseline, corneal curvature (CC) became flatter in both groups (7.6 ± 0.27 vs 7.7 ± 0.26 mm; p < 0.001) during the follow-up, but the difference did not reach significance between groups. Corneal astigmatism was most commonly with-the-rule in both groups (37 (50.0%) vs 148 (68.5%); p > 0.05). Age, sex and PEX had no influence on age-related macular degeneration distribution. Conclusion The prevalence of PEX increased significantly with age in our population, with those with PEX having thinner and flatter corneae, but no difference in cataract and age-related macular degeneration characteristics.

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Section: Discussionmentioning

confidence: 99%

Exploring association between pseudoexfoliation syndrome and ocular aging

et al. 2022

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“…On the contrary, Krysik found CCT thicker in PEX group [41]. Many authors report that there is no signi cant difference in CCT between PEX and no-PEX groups [7,37,38,[42][43][44][45].…”

Section: Discussionmentioning

confidence: 97%

Pseudoexfoliation Syndrome Association with Aging and Ocular Changes in Cornea, Lens, Retina

Rumelaitienė

Žaliūnienė

Špečkauskas

et al. 2021

Preprint

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Purpose: To examine the 10-year incidence of the pseudoexfoliation syndrome (PEX), possible risk factors of PEX, and its association with aging and ocular changes in cornea, lens, retina within a population-based follow-up study.Methods: The baseline examination was conducted in 2006 on a random sample of 1,033 adult participants from Kaunas city (Lithuania) population. Out of them 631 participants returned to the follow-up study in 2016. Ophthalmological examination included keratometry, central corneal pachymetry, after diagnostic mydriasis lens opacification was evaluated by LOCS III International classification, PEX was diagnosed by the presence of typical grayish-white exfoliation material on the anterior capsule surface of the lens.Results: During the 10 years follow-up, the prevalence of the PEX increased from 9.8% to 34.2%. Nuclear cataract was diagnosed the most both in the PEX-group and those without, however, there was no statistically significantly increased risk of developing cataract in those with PEX when compared to those without PEX (OR 1.2; p=0.61). Central corneal thickness (CCT) was thinner in PEX group (529±34μm) and in the eldest group (525±36μm) (p<0.001). Compared to baseline, corneal curvature (CC) became steeper both in the PEX and the no-PEX groups during the follow-up (p=0.013), but the difference didn’t reach significance between groups. The biggest part of corneal astigmatism was with-the-rule in no-PEX and PEX groups (37 vs 148; p>0.05). The age, sex and PEX had no influence to age related macular degeneration distribution.Conclusion: The prevalence of the PEX increased significantly with age. CCT was thinner in PEX group and in elder people. CC was flatter in PEX group.

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“…Little is known about the exact iridocorneal angle size (ICAS) in PACG as most of the published literature on PACG covers other parameters such as anterior chamber depth (ACD), angle opening distance (AOD) or lens thickness (LT). Aksoy NÖ et al [ 35 ] reported a mean ACA of 24.2° ± 2.6° in the PACG group vs. 30.5 ± 2.3 in the control group measured by dual Scheimpflug imaging. Leong et al [ 36 ] published a trabecular-iris angle (TIA) of 6.8° ± 4.9° before and of 14° ± 6.7° after laser peripheral iridoplasty (LPI) measured by AS-OCT what is in line with post-LPI data of Ma et al [ 37 ] for anterior chamber angle (ACA) values from 12.91° ± 6.31° to 16.45° ± 5.87° (depending on the measuring position) after a laser peripheral iridotomy.…”

Section: Discussionmentioning

confidence: 99%

Effect of the iridocorneal angle size on the diurnal pressure profile in a glaucoma suspect cohort and patients with glaucoma

Müller,

Pavlovic,

Niermann

et al. 2023

Int Ophthalmol

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Purpose To evaluate the impact of the iridocorneal angle size (ICAS) on the diurnal intraocular pressure (IOP) in patients with suspected glaucoma (SG). Method Patients with any eye-pressure lowering medication or previous ocular surgery were excluded. In a retrospective study set, diurnal IOP profiles of 120 patients (205 eyes) within a 48-h period were analysed by regression analysis. Of those eyes, 44 were diagnosed to have glaucoma. The remaining eyes were used as healthy control group (HCG). Results The overall mean IOP was 15.63 mmHg ± 2.72 mmHg and mean ICAS was 23.92° ± 4.74°. In the glaucoma cohort, mean IOP was 18.77 ± 1.86 mmHg and mean ICAS was 25.02° ± 4.96°. In the HCG, mean IOP was 14.77 ± 2.25 mmHg and mean ICAS was 23.62° ± 4.64°. In the total cohort, as well as in the subgroups (HCG or glaucoma), regression analysis showed no significant impact even of the minimum ICAS, which was larger than 10°, on average (P = 0.89), maximum (P = 0.88), and range of IOP (P = 0.49) within 48 h. The difference between glaucoma cohort and HCG cohort was significant in terms of IOP (P < 0.001), but not for minimum ICAS (P = 0.07). Chi-square test showed no increase in prevalence of IOP peaks of > 21 mmHg within 48 h in eyes with an angle between 10° and 20° (P = 0.18). Conclusion An ICAS of larger than 10° in HCG or glaucoma patients with an open-angle does not influence the minimum, average, maximum or range of IOP. Additionally, an angle size larger than 10° does not allow the prediction of IOP changes in these two cohorts.

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Evaluation of Anterior Segment Parameters in Pseudoexfoliative Glaucoma, Primary Angle-Closure Glaucoma, and Healthy Eyes

Cited by 7 publications

References 29 publications

Exploring association between pseudoexfoliation syndrome and ocular aging

Exploring association between pseudoexfoliation syndrome and ocular aging

Pseudoexfoliation Syndrome Association with Aging and Ocular Changes in Cornea, Lens, Retina

Effect of the iridocorneal angle size on the diurnal pressure profile in a glaucoma suspect cohort and patients with glaucoma

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