Evaluation of androgen receptor transcriptional activities of bisphenol A, octylphenol and nonylphenol in vitro

Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products

“…Triclosan and thymol are also commonly used in cosmetic and personal care products (Nakada et al, 2006) and previous studies report that most estrogenic and antiandrogenic EDS contain a phenolic moiety (Kuiper et al, 1998;Kitamura et al, 2005;Xu et al, 2005). As predicted by the structural similarities of these compounds, the present data demonstrate that parabens containing a methyl, butyl or propyl moiety, triclosan and thymol are antiandrogenic with varying potencies.…”

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

“…Transfected cell-based assays have not identified bisphenol A as having androgenic activity (Sohoni and Sumpter, 1998;Gaido et al, 2000;Kitamura et al, 2005;Xu et al, 2005). However, bisphenol A is mitogenic in cultured human prostate carcinoma cells at a concentration of 1 nM (Wetherill, 2002).…”

In vitro thyroid disrupting effects of organic extracts from WWTPs in Beijing

“…Given that the major mechanism of TH action involves T 3 binding to its nuclear receptors (Helbing et al, 1992), and many environmental contaminants including BPA, pestisides, phthalates, and phenols, which are usually detected in the wastewaters (Sohoni and Sumpter, 1998;Xu et al, 2005) can directly interfering with thyroid receptors (TRs) (Zoeller, 2005), elimination of TR disrupting substances during wastewater treatment process and assessing the disrupting potency are of considerable environmental importance.…”