Evaluation of androgen-dependent skin findings of polycystic ovary syndrome (PCOS)

Artar, Gokhan; Taş, Betül; Turan, Gökçe; Uçkan, Hasan

doi:10.1080/09513590.2022.2162496

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Although the lipid-lowering drugs are not used as the first-line drugs for PCOS, the regulation of blood lipids is still poor after active intervention, and statins should be considered. The study showed that the androgen level in PCOS patients decreased after long-term use of simvastatin, and the blood lipid metabolism improved significantly (Artar et al, 2022). Atorvastatin can improve the hormone level and insulin resistance of obese PCOS patients, and improve their inflammatory level in vivo (Chen and Zheng, 2021).…”

Section: Other Drugsmentioning

confidence: 95%

Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications

Sun

Gao

et al. 2023

Front. Cell. Infect. Microbiol.

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Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis of PCOS is complex and has not yet been fully clarified. Gut microbiota is associated with disorders of lipid, glucose, and steroid hormone metabolish. A large body of studies demonstrated that gut microbiota could regulate the synthesis and secretion of insulin, and affect androgen metabolism and follicle development, providing us a novel idea for unravelling the pathogenesis of PCOS. The relationship between gut microbiota and the pathogenesis of PCOS is particularly important. This study reviewed recent research advances in the roles of gut microbiota in the occurrence and development of PCOS. It is expected to provide a new direction for the treatment of PCOS based on gut microbiota.

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Section: Other Drugsmentioning

confidence: 95%

Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications

Sun

Gao

et al. 2023

Front. Cell. Infect. Microbiol.

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“…In the presence of acanthosis nigricans, it is essential to rule out peripheral insulin resistance, which would require a full laboratory test assessment to be implemented. 69 In obese patients, evaluation for metabolic syndrome should be initiated. 70 Acne is generally a clinically-made diagnosis, without requiring additional testing (Figures 1 and 2).…”

Section: Issues Relating To Diagnosismentioning

confidence: 99%

Unveiling the Nuances of Adult Female Acne: A Comprehensive Exploration of Epidemiology, Treatment Modalities, Dermocosmetics, and the Menopausal Influence

Dias da Rocha,

Saint Aroman,

Mengeaud

et al. 2024

IJWH

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Previously considered a skin disease exclusively affecting adolescents, characterized by inflammatory and non-inflammatory skin lesions, acne vulgaris is now increasingly observed in adult life, including post-menopause. Today, adult female acne (AFA) is a common chronic inflammatory disease of the pilosebaceous unit, with polymorphic lesions presenting as open or closed comedones, papules, pustules, and even nodules or cysts, often with the presence of sequelae. AFA may persist from adolescence or manifest de novo in adulthood. Its etiology is multifactorial, involving genetic, hormonal, dietary, and environmental factors, yet still incompletely understood. Increased sebum production, keratinocyte hyper-proliferation, inflammation, and reduced diversity of Cutibacterium acnes strains are the underlying disease mechanisms. During menopausal transition, a relative increase in androgen levels occurs, just as estrogens begin to decline, which can manifest itself as acne. Whereas most AFA exhibit few acne lesions with normo-androgenic serum levels, baseline investigations including androgen testing panel enable associated comorbidities to be eliminated, such as polycystic ovarian syndrome, congenital adrenal hyperplasia, or tumors. Another interesting feature is AFA’s impact on quality of life, which is greater than in adolescents, being similar to other chronic diseases like asthma. The therapeutic approach to AFA depends on its severity and associated features. This review investigates the intricate facets of AFA, with a specific focus on incidence rates, treatment modalities, and the curious impact of menopause. Utilizing insights from contemporary literature and scientific discussions, this article seeks to advance our understanding of AFA, offering new perspectives to shape clinical practices and improve patient outcomes.

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Endocrinological and Metabolic Heterogeneity Is Low in Japanese Women With Polycystic Ovary Syndrome

Baba,

Endo,

Mariya

et al. 2024

Journal of Obstetrics and Gynaecology Canada

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Evaluation of androgen-dependent skin findings of polycystic ovary syndrome (PCOS)

Cited by 4 publications

References 21 publications

Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications

Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications

Unveiling the Nuances of Adult Female Acne: A Comprehensive Exploration of Epidemiology, Treatment Modalities, Dermocosmetics, and the Menopausal Influence

Endocrinological and Metabolic Heterogeneity Is Low in Japanese Women With Polycystic Ovary Syndrome

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