Evaluation of analytical methods and workflow performance of the Architect ci8200 integrated serum/plasma analyzer system

Hubl, W; Zogbaum, Martina; Boyd, James C.; Savory, John; Schubert, Mary; Meyer, Dirk C.; Demant, Thomas

doi:10.1016/j.cccn.2005.01.032

Cited by 20 publications

(9 citation statements)

References 12 publications

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“…For setting the criteria for acceptable imprecision and inaccuracy, we considered the biological variations of analytes (7,10,11). Depending on the measurement procedure, measuring instruments and compliance with a reference or de nitive method, we can assess whether the new method or analyzer is suitable for routine use, and whether they are of satisfactory accuracy (2,3,5,12). For most analytes tested in this study, the results of imprecision and bias were in the range of desirable speci cations for imprecision and bias, derived from biological variation (10,11).…”

Section: Discussionmentioning

confidence: 99%

Analytical evaluation of the clinical chemistry analyzer Olympus AU2700 plus

et al. 2010

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Background: The objective of this study was to perform the analytical evaluation of the clinical chemistry analyzer Olympus AU2700 plus. The evaluation was performed according to the guidelines of the European Committee for Clinical Laboratory Standards (ECCLS). Materials and methods:The evaluation consisted of determination of within-run and between-run imprecision, inaccuracy and comparison with Olympus AU2700. The tested analytes were: glucose, creatinine, urate, total bilirubin, cholesterol, tryglicerides, calcium, phosphate, iron, unsaturated iron binding capacity, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, creatine kinase, alpha-amylase, alkaline phosphatase, potassium, sodium, chloride, C-reactive protein, antistreptolysin O and rheumatoid factor. Results: The results showed low within-run and between-run imprecision and acceptable inaccuracy for all analytes. High correlation with AU2700 analyzer was found. Intercept and slope (with 95% con dence interval) met the preferences of Passing-Bablok regression for all of the analytes except alanine aminotransferase, sodium, rheumatoid factor, creatine kinase, total bilirubin and tryglicerides. Conclusions: Olympus AU2700 plus analyzer shows acceptable precision and accuracy for majority of analytes, with the exception of sodium and chloride. Instrument is fully comparable with Olympus AU2700 analyzer for all but several analytes (ALT, RF, sodium, CK, total bilirubin and tryglicerides), where only some minor deviations (constant and proportional di erence) were observed.

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Section: Discussionmentioning

confidence: 99%

Analytical evaluation of the clinical chemistry analyzer Olympus AU2700 plus

et al. 2010

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“…Plasma concentrations of: 1) homocysteine, B 12 and folate; 2) zinc and selenium; and 3) carotenoids were determined by: 1) the ARCHITECT folate assay [15]; 2) inductively coupled plasma optical emission spectroscopy (ICPOES) [16]; and 3) High Performance Liquid Chromatography (HPLC) [17], respectively.…”

Section: Homocysteine and Dietary Micronutrient Measurementsmentioning

confidence: 99%

Predictors of radiation-induced gastrointestinal morbidity: A prospective, longitudinal study following radiotherapy for carcinoma of the prostate

et al. 2016

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Background Chronic gastrointestinal (GI) morbidity occurs in ≥50% of patients after external beam radiotherapy (EBRT) for carcinoma of prostate (CaP). This prospective, longitudinal study examines which baseline measurements of: 1) homocysteine and micronutrients in plasma; 2) chromosome damage/misrepair biomarkers; and 3) anal and rectal dose volume metrics predict GI morbidity after EBRT. Patients and methods In total, 106 patients with CaP had evaluations of GI symptoms (modified LENT-SOMA questionnaires) before EBRT and at one month, one, two and three years after its completion. Other variables measured before EBRT were: 1) plasma concentrations of homocysteine and micronutrients including caroteinoids and selenium; 2) chromosome damage/DNA misrepair (micronuclei/nucleoplasmic bridge) indices; and 3) mean anal and rectal wall doses and volumes of anal and rectal walls receiving ≥40 Gy and ≥60 Gy. Univariate and multivariate analyzes examined the relationships among: 1) plasma levels of homocysteine and micronutrients; 2) indices of chromosome damage/DNA misrepair; and 3) mean anal and rectal wall doses and volumes of anal and rectal walls receiving ≥40 Gy and ≥60 Gy and total GI symptom scores from one month to three years after EBRT. Results Increased frequency and urgency of defecation, rectal mucous discharge and bleeding after EBRT resulted in sustained rises in total GI symptom scores above baseline at three years. On univariate analysis, total GI symptom scores were significantly associated with: 1) plasma selenium and α tocopherol; 2) micronuclei indices of DNA damage; 3) mean anal and rectal wall doses; and 4) volumes of anal and rectal wall receiving ≥40 Gy and ≥60 Gy (p = 0.08-<0.001). On multivariate analysis, only volume of anal wall receiving ≥40 Gy was significant for increased GI symptoms after EBRT (p < 0.001). Conclusion The volume of anal wall receiving ≥40 Gy predicts chronic GI morbidity after EBRT for CaP.

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“…The rats were placed in metabolic cages for assessment of proteinuria. The concentrations of Scr, BUN and urinary protein were measured with an Olympus AU640 automatic analyser and all reagents were from Olympus Diagnostics [27,28] . The concentrations of serum potassium, sodium and chlorine were measured with an Easylyte plus Analyzer (Medica, America) [29] .…”

Section: Methodsmentioning

confidence: 99%