Evaluation of Analgesic Effect of Human Saliva

Abstract

Opioids are one of the most effective analgesics used commonly in recent times but human saliva is an amazing natural pain killer that produces the analgesic effect as that of opioids. The study is designed to evaluate the analgesic effect of human saliva in different doses. The study is carried out on albino mice weighing 20-25gm. Mice were divided into 5 groups each containing 6 mice. Group I was taken as control and administered distilled water 0.2ml, group II, III and IV were taken as treated. Group II was administered 0.2ml saliva; group III 0.4ml and to group IV 0.6ml saliva was administered. Group V was given acetyl salicylic acid (300mg/60kg).The saliva was taken from same healthy female subject for all doses. The tail flick test was performed for evaluation of analgesic effects.From our study we observed that maximum analgesic effect was observed at 90 minutes (4.6sec±0.10) by 0.2ml dose. However on increasing dose to 0.4ml maximum analgesic activity was observed at 120minutes (6.7±0.10), whereas at 0.6ml dose maximum effect was observed at 180 minutes (4.6sec±0.08). Maximum activity by standard was observed at 120 minutes (6.9±0.09).Our study indicates that human saliva at 0.4ml shows effects like standard however there is significant decrease in analgesic activity as compared to standard (moderate analgesic effect). The results might vary with change in subjects and further studies can be conducted on this point. This study gives us hope that in future it will be very easy to relieve pain especially free of addiction and adverse effects.

The Influence of Mobile Phone Addiction on Left-Behind Middle School Students' Sleep Quality: The Mediator Role of Loneliness

“…As shown by a recent study, 43.5% of people use a mobile phone for 8 hours per day, while 24% use a mobile phone for 16 hours per day. Besides, the results reveal the highest figure (41.5%) of 1-4 hour of total call time an individual spends each day (Sarfaraz et al, 2015). Like some other addictive behaviors, mobile phone addiction is characterized by compulsiveness, loss of self-control and ongoing harmful behaviors.…”

“…Como muestra un estudio reciente, el 43,5% de las personas utilizan un teléfono móvil durante 8 horas al día, mientras que el 24% utilizan un teléfono móvil durante 16 horas al día. Además, los resultados revelan la cifra más alta (41,5%) de 1-4 horas de tiempo total de llamadas al día por individuo (Sarfaraz et al 2015). Al igual que otras conductas adictivas, la adicción al teléfono móvil se caracteriza por compulsividad, pérdida de autocontrol y conductas perjudiciales.…”