Evaluation of Analgesic, Anti-inflammatory and CNS Depressant Potential of Dendrophthoe falcata (Linn.) Leaves Extracts in Experimental Mice Model

Haque, Anamul; Zaman, Afrina; Hossain, Md. Imam; Sarker, Icha; Islam, Saiful

doi:10.5099/aj140300139

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…Changes in behavioral parameters or exploratory activities in Hole cross and Open field tests validates the effect of administered drug or test sample [22]. Gamma-amino-butyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system [23].…”

Section: Discussionmentioning

confidence: 83%

Antipyretic, Antidiabetic, Thrombolytic and CNS Depressant Potential of Ethanol Extract of Crotalaria Verrucosa L. Leaves

Nawrin¹,

Billah²,

Jabed³

et al. 2015

Am. J. Biomed. Sci.

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Hyperthermia, hyperglycemia, depression are the most common physiological disorders found in third world countries where people are not well aware of their health condition as well as about their health practice. People in rural and tribal areas depend on the traditional system of medicine where allopathic medicines are not the first choice because of ethnicity and belief. The plant Crotalaria verrucosa is believed as one of the cures in traditional system of medicine for many ailments. The present study was performed to evaluate the antipyretic, antidiabetic, thrombolytic and depressive potential of the leaf extract of this plant. Yeast induced pyrexia, alloxan induced type II hyperglycemia, HRBC clot denaturation, Hole cross and Open field tests were performed to investigate these activities at moderate to high doses (100, 250 and 500 mg/kg). Results of the study suggests that the extract possess strong antipyretic, antidiabetic and CNS depressant activity in higher doses (250 and 500 mg/kg) but lack to exhibit clear thrombolytic potential.

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Section: Discussionmentioning

confidence: 83%

Antipyretic, Antidiabetic, Thrombolytic and CNS Depressant Potential of Ethanol Extract of Crotalaria Verrucosa L. Leaves

Nawrin¹,

Billah²,

Jabed³

et al. 2015

Am. J. Biomed. Sci.

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“…The gavage of petroleum ether fraction of DF leaves growing on Swietenia fabrilis Salisb. (200 mg/kg) was found to exert pharmacological activity against paw edema in mice induced by carrageenan with an inhibitory volume of 90.24% ( Haque et al, 2014c ).…”

Section: Pharmacologymentioning

confidence: 99%

Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications

et al. 2023

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Dendrophthoe falcata (L.f.) Ettingsh. (DF) and Dendrophthoe pentandra (L.) Miq. (DP) have been traditionally used for the treatment of various ailments, such as cancer, ulcers, asthma, paralysis, skin diseases, tuberculosis, and menstrual troubles, in the ethnomedicinal systems of India and Indonesia. Currently, the chemical structures of 46 compounds have been elucidated from DF and DP, including flavonoids, triterpenes, tannins, steroids, open-chain aliphatics, benzyl derivates, and cyclic chain derivatives. In vitro assays have revealed their anti-tumor and anti-microbial activities. In vivo studies have unraveled their pharmacological properties against tumors, depression, fertility disorders, inflammatory responses, and so on. Additionally, their weak toxicity to rats and brine shrimp, as well as their promising applications for pharmaceutical preparations and combined medication, were also revealed. Herein, we not only recapitulated traditional medical uses, phytochemistry, pharmacology, toxicity, and applications of DF and DP but also discussed current research limitations and future perspectives, which are instructive for those interested in them and are committed to advancing parasitic plants to the Frontier of phytomedicine. We highlighted that DF and DP will become promising medical plants rather than being discarded as notorious pests, provided that more and deeper research is undertaken.

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Emilia coccinae (SIMS) G Extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in scopolamine-treated rats

Foyet

Abaïssou

Wado

et al. 2015

BMC Complement Altern Med

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BackgroundE. coccinae (SIMS) G. (Asteraceae) is an annual plant commonly found throughout the plain of the Central Africa and widely used in Cameroonian folk medicine for the treatment of fever and convulsions in children. We previously reported that the methanolic extract of this plant improved spatial memory. However no underlying mechanism was explored. The present study was undertaken to investigate the effects of the hydroalcoholic extract of Emilia coccinae on memory in scopolamine treated rats and to propose possible mechanisms of action.MethodsNovel object recognition and Y-maze paradigm were used to test memory while oxidative profile, AChE and ACh level of the whole brain were assessed to outline the mechanism of nootropic activity of the extract. 200 and 400 mg/kg of the extract were chronically administrated during 14 consecutive days in separate groups of scopolamine intraperitoneal treated rats (1.5 mg/kg).ResultsThe hydroalcoholic extract of Emilia coccinae (HEEC) at the dose of 200 mg/kg significantly improved the memory of rats and reversed the amnesia induced by scopolamine. In addition, we showed that this extract is decreasing the acetyl cholinesterase activity while also increasing the acetylcholine levels in the brain. HEEC (200 and 400 mg/kg) significantly increased antioxidant enzyme activities (SOD, GSH and CAT) and reduced lipid peroxidation (MDA level) in the rat whole brain homogenates.ConclusionsTaken together, our results suggested that the hydroalcoholic extract of Emilia coccinae ameliorated the cognitive dysfunction in scopolamine treated rats through the blockage of the oxidative effect of scopolamine and inhibition of AChE activity.

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Evaluation of Analgesic, Anti-inflammatory and CNS Depressant Potential of Dendrophthoe falcata (Linn.) Leaves Extracts in Experimental Mice Model

Cited by 3 publications

References 49 publications

Antipyretic, Antidiabetic, Thrombolytic and CNS Depressant Potential of Ethanol Extract of Crotalaria Verrucosa L. Leaves

Antipyretic, Antidiabetic, Thrombolytic and CNS Depressant Potential of Ethanol Extract of Crotalaria Verrucosa L. Leaves

Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications

Emilia coccinae (SIMS) G Extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in scopolamine-treated rats

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