Evaluation of Analgesic Activities of Tremetone Derivatives Isolated from the Chilean Altiplano Medicine <i>Parastrephia lepidophylla</i>

Benites, Julio; Gutierrez, Eunices; López, Javier Sánchez; Rojas, Mauricio; Rojo, Leonel E.; Costa, Maria do Céu; Vinardell, María Pilar; Calderón, Pedro Buc

doi:10.1177/1934578x1200700517

Cited by 11 publications

(14 citation statements)

References 20 publications

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“…The native plant Parastrephia lucida (Meyen) Cabrera is a native shrub, commonly called umatola, growing in the pre-cordillera and Altiplano in the North of Chile and Argentina (Benites et al, 2012, CONAMA, 2008, D'Almeida et al, 2012, Marticorena, 2009). This species has been historically used in traditional medicine as an anti-inflammatory agent, to treat toothache (Villagrán et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

High resolution UHPLC-MS characterization and isolation of main compounds from the antioxidant medicinal plant Parastrephia lucida (Meyen)

Echiburú-Chau

Pasten

Parra

et al. 2017

Saudi Pharmaceutical Journal

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High-resolution mass spectrometry is currently used to determine the mass of biologically active compounds in medicinal plants and food and UHPLC-Orbitrap is a relatively new technology that allows fast fingerprinting and metabolomics analysis. Forty-two metabolites including several phenolic acids, flavonoids, coumarines, tremetones and ent-clerodane diterpenes were accurately identified for the first time in the resin of the medicinal plant (Asteraceae) a Chilean native species, commonly called umatola, collected in the pre-cordillera and altiplano regions of northern Chile, by means of UHPLC-PDA-HR-MS. This could be possible by the state of the art technology employed, which allowed well resolved total ion current peaks and the proposal of some biosynthetic relationships between the compounds detected. Some mayor compounds were also isolated using HSCCC. The ethanolic extract showed high total polyphenols content and significant antioxidant capacity. Furthermore, several biological assays were performed that determined the high antioxidant capacity found for the mayor compound isolated from the plant, 11--coumaroyloxyltremetone.

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Section: Introductionmentioning

confidence: 99%

High resolution UHPLC-MS characterization and isolation of main compounds from the antioxidant medicinal plant Parastrephia lucida (Meyen)

Echiburú-Chau

Pasten

Parra

et al. 2017

Saudi Pharmaceutical Journal

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“…Screening of the plants focusing on bioactivities is essential to find out disease specific drug candidates. [1][2][3] Pain is always associated with injury and some disease states. It may be very fatal for some patients.…”

Section: Introductionmentioning

confidence: 99%

Analgesic and antidepressant activities of Brassica rapa subspecies chinensis (L.) Hanelt on Swiss-albino mice model

Rahman

Jahan

Rahman

et al. 2016

Bangladesh Med Res Counc Bull

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Bangladesh being a subtropical country provides varieties of herbs and vegetables. Brassica is a broad genus available in Bangladesh and it encompasses a lot of nutritive herbs. Among these, Brassica rapa subspecies chinensis (L.) Hanelt (Family-Brassicaceae) is popular in many parts of the world. In the quest of medicinal property, this plant was investigated here for observing analgesic and antidepressant activities in Swiss-albino mice model. The herb was extracted well with methanol and then assayed by acetic acid-induced writhing and tail immersion methods for analgesic action. Besides, thiopental sodium induced sleeping time test, tail suspension test and forced swim test were conducted for the evaluation of its antidepressant activity. The plant extract was orally administered to the mice at 200 and 400 mg/kg body weight and it exhibited significant analgesic and antidepressant activities in compare to the controlled groups. This is the first time comprehensive report for analgesic and antidepressant activities of this plant.

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“…Octanol-water partition coefficient (LogP) values were calculated for all compounds as described by Benites et al (2012).…”

Section: Methodsmentioning

confidence: 99%

Inhibition of Escherichia coli and Bacillus subtilis FtsZ Polymerization and Bacillus subtilis Growth by Dihydroxynaphtyl Aryl Ketones

et al. 2019

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The increasing detection of virulent and/or multidrug resistant bacterial strains makes necessary the development of new antimicrobial agents acting through novel mechanisms and cellular targets. A good choice are molecules aimed to interfere with the cell division machinery or divisome , which is indispensable for bacterial survival and propagation. A key component of this machinery, and thus a good target, is FtsZ, a highly conserved GTPase protein that polymerizes in the middle of the cell on the inner face of the cytoplasmic membrane forming the Z ring, which acts as a scaffold for the recruitment of the divisome proteins at the division site. In this work, we tested the inhibitory effect of five diaryl naphtyl ketone (dNAK) molecules on the in vitro polymerization of both Escherichia coli and Bacillus subtilis FtsZ (EcFtsZ and BsFtsZ, respectively). Among these compounds, dNAK 4 showed the strongest inhibition of FtsZ polymerization in vitro , with an IC 50 of 2.3 ± 0.06 μM for EcFtsZ and 9.13 ± 0.66 μM for BsFtsZ. We found that dNAK 4 binds to GDP-FtsZ polymers but not to the monomer in GTP or GDP state. This led to the polymerization of short and curved filaments, rings, open rings forming clusters, and in the case of BsFtsZ, a novel cylindrical structure of stacked open rings. In vivo , dNAK 4 had almost no effect on the growth of E. coli in liquid culture, in contrast to the strong inhibitory effect observed over B. subtilis growth. The insensitivity of E. coli to this compound is probably related to the impermeability of dNAK 4 to the outer membrane. The low amount of this compound required to inhibit several of the bacterial strains tested and the lack of a cytotoxic effect at the concentrations used, makes dNAK 4 a very good candidate as a starting molecule for the development of a new antibiotic.

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Evaluation of Analgesic Activities of Tremetone Derivatives Isolated from the Chilean Altiplano Medicine Parastrephia lepidophylla

Cited by 11 publications

References 20 publications

High resolution UHPLC-MS characterization and isolation of main compounds from the antioxidant medicinal plant Parastrephia lucida (Meyen)

High resolution UHPLC-MS characterization and isolation of main compounds from the antioxidant medicinal plant Parastrephia lucida (Meyen)

Analgesic and antidepressant activities of Brassica rapa subspecies chinensis (L.) Hanelt on Swiss-albino mice model

Inhibition of Escherichia coli and Bacillus subtilis FtsZ Polymerization and Bacillus subtilis Growth by Dihydroxynaphtyl Aryl Ketones

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