Evaluation of amylase and lipase in the diagnosis of acute pancreatitis

Treacy, J; Williams, Angie; Bais, Renz; Willson, Krysten; Worthley, C. S.; Reece, John; Bessell, J. R.; Thomas, David B.

doi:10.1046/j.1445-2197.2001.02220.x

Cited by 110 publications

(76 citation statements)

References 21 publications

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“…There is still a controversy over the diagnostic value of serum lipase activity in feline AP (4, 7), which may be of some help in the diagnosis of human and canine disease (20)(21). In this study, we noticed an increase of serum lipase activity 8 hours after induction of pancreatitis that remained high until the 8 th and then until the 16 th day postoleic acid infusion.…”

Section: Discussionsupporting

confidence: 49%

Clinical and Laboratory Investigation of Experimental Acute Pancreatitis in the Cat

Zavros¹,

Rallis²,

Koutinas³

et al. 2008

Eur J Inflamm

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The main objective of this study is the serial evaluation of clinical and laboratory changes in cats with experimentally-induced acute pancreatitis (AP). A total of 16 clinically healthy young adult DSH cats were included in the study. Acute pancreatitis was induced in 10 (AP group) by infusing oleic acid into the pancreatic duct, while the other 6 cats served as sham-operated controls (C group). Depression or lethargy, anorexia, abdominal pain, and a palpable mass in the anterior abdomen were the main clinical findings in cats of the AP group. Laboratory data revealed non-regenerative anaemia, mild hypoalbuminaemia, transient hyperglycaemia, and hypertriglyceridaemia. Serum lipase activity, feline trypsin-like immunoreactivity (ITLI) concentration, and feline pancreatic lipase immunoreactivity (fPLI) concentration increased significantly within the first 24 hours after the infusion of oleic acid, with time-dependent positive correlation. In both group of cats urine amylase-creatinine ratio and amylase-creatinine clearance ratio were increased. In cats of the AP group, abdominal ultrasonography revealed a hypoechogenic and enlarged pancreas, along with peripancreatic fluid accumulation. Peritoneal effusion was consistent with a sterile exudate, with higher lipase but lower amylase activities when compared to their serum counterparts in all AP group cats. The induction of AP was confirmed by pancreatic histopathology. AP is characterized by vague symptomatology. Increases in serum ITLI and fPLI concentrations occur early in cats with pancreatitis. In general the two analytes run a parallel course, but fPLI may be increased longer than ITLI. The measurement of lipase activity in the peritoneal fluid could be considered diagnostic.Despite the fact that acute pancreatitis (AP) in the cat is difficult to diagnose, it is widely accepted that it is a rather commonly occurring though underdiagnosed disease (1-2). The aetiopathogenesis of feline AP is poorly understood, although it has been attributed to several causative and risk

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Section: Discussionsupporting

confidence: 49%

Clinical and Laboratory Investigation of Experimental Acute Pancreatitis in the Cat

Zavros¹,

Rallis²,

Koutinas³

et al. 2008

Eur J Inflamm

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“…Treacy et al had found a sensitivity of 45% for serum amylase using three times the upper limit of normal values for serum amylase as the cut off for diagnosis. 10 The findings of sensitivity in our study correlates closely to that by Treacy et al However, Kempainnem 11 et al and Ventrucci 12 et al found a higher sensitivity of about 83% and 88% respectively. This might be because both the study used serum amylase for the diagnosis of acute pancreatitis, while Treacy et al like us used USG for the diagnosis of acute pancreatitis.…”

Section: Discussionsupporting

confidence: 81%

Comparative Study on Sensitivity of Serum and Urinary Amylase in the Diagnosis of Acute Pancreatitis

Gupta¹

2017

jmscr

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“…This finding is consistent with the findings proposed in the study of Owen J. O'Connor, Sebastian McWilliams et al 10 In the present study, the elevated serum lipase was found to have higher sensitivity (89.09%) in detecting the acute pancreatitis than the serum amylase (65.4%). This finding is similar to that of the study done by Treacy J et al 11 The higher sensitivity of both in the present study may be due to the fact that most of the cases were of severe pancreatitis and the small study group. In the present study, there were five cases (19.04%) which had vascular complications.…”

Section: Prognostic Criteria Used For Evaluation Modified Ct Severitysupporting

confidence: 81%

Acute Pancreatitis and Its Complications: MDCT Versus Usg: An Overview

Gonegandla¹,

Ayesha²,

G³

et al. 2016

jemds

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OBJECTIVEImaging plays a central role in the management of selected cases of acute pancreatitis and its complications, complementing laboratory investigations such as serum amylase and lipase levels that have relatively high sensitivity and specificity. In addition to clinical signs and laboratory investigations, imaging helps in confirming the clinical diagnosis when there is uncertainty and elucidates the cause and grade the extent and severity of acute pancreatitis. It also aids in the early detection of complications. MATERIAL AND METHODSUltrasound and CECT Abdomen were done in 55 patients with a typical clinical suspicion of acute pancreatitis. The findings were correlated with biochemical parameters and the discrepancy between the two modalities i.e. USG and CT was evaluated. RESULTSAbout 55 cases were studied and they were subjected to USG and CT (plain and contrast). Most of the patients were males with male to female ratio 13:1. Most common aetiology was chronic alcohol consumption (42 cases, 76.33%) followed by idiopathic (11 cases, 20%) and trauma (2 cases, 3.66%). Multiple sites of involvement (35 cases, 63.65%) was more common than focal involvement of pancreas. Severe form of pancreatitis (37 cases, 67.27%) was the most common type according to MCTSI. The most common complication was ascites (cases, 56.36%) and pleural effusion (16 cases, 29.09%). CONCLUSIONThe sensitivity of USG in detecting acute pancreatitis was 41.8%. The sensitivity of CT (plain and contrast) in detecting pancreatitis was 100%. Modified CT severity index shows significant correlation between severity of pancreatitis and patient outcome. Serum lipase is more accurate in detecting acute pancreatitis than serum amylase. Thus, from the present study, it can be concluded that CT (plain and contrast) is superior in detecting and evaluating pancreatitis. Hence, CT plain and contrast should be performed in all cases of clinically suspected pancreatitis especially with positive serological findings.

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Evaluation of amylase and lipase in the diagnosis of acute pancreatitis

Abstract: Serum lipase is recommended for diagnosis of AP, both early and late in the disease. Although highly specific when elevated, all pancreatic enzymes have low sensitivity for diagnosis.

Cited by 110 publications

References 21 publications

Clinical and Laboratory Investigation of Experimental Acute Pancreatitis in the Cat

Clinical and Laboratory Investigation of Experimental Acute Pancreatitis in the Cat

Comparative Study on Sensitivity of Serum and Urinary Amylase in the Diagnosis of Acute Pancreatitis

Acute Pancreatitis and Its Complications: MDCT Versus Usg: An Overview

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