Evaluation of Amylase Activity in Patients with Type 2 Daibetes Mellitus

Ewadh, Mufeed J.

doi:10.11648/j.ajbio.20140205.11

Cited by 14 publications

(11 citation statements)

References 20 publications

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“…This finding was in agreement with results of some workers 6,11,16,17,[20][21][22] . On the contrary, some researchers found serum amylase level was significantly higher in type 2 diabetic subjects 23,24 .…”

Section: Discussionsupporting

confidence: 94%

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Serum amylase and lipase levels in type 2 diabetes mellitus

Tanvi

Akhter

Nahar

et al. 2018

J Bangladesh Soc Physiol

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Background: In diabetes mellitus, impaired pancreatic endocrine activity may affect its exocrine function causing mal digestion and malnutrition.Objective: To assess serum amylase and lipase levels in subjects with type 2 diabetes mellitus (T2DM).Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from January 2015 to December 2015. Fifty type 2 diabetic subjects with age ranging from 40 to 55 years of both sexes were enrolled in this study and 50 age matched healthy subjects were control group. Patients were enrolled from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka. Serum amylase and serum lipase levels were estimated by spectrophotometry. For statistical analysis, unpaired Student ‘t’ test was done.Results: In this study, serum amylase and lipase levels were significantly lower (P<0.001) in comparison to control group.Conclusion: From this study, it is concluded that, exocrine derangement of pancreas may occur in type 2 diabetes mellitus.Bangladesh Soc Physiol. 2017, December; 12(2): 52-56

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Section: Discussionsupporting

confidence: 94%

“…The relationship between serum amylase and duration of disease was statistically significant.Similar finding was also made by other research workers 20 . Amylase in type 2 diabetic subjects became more severely affected in long-standing cases of diabetes mellitus 16 .…”

Section: Discussionsupporting

confidence: 92%

Serum amylase and lipase levels in type 2 diabetes mellitus

Tanvi

Akhter

Nahar

et al. 2018

J Bangladesh Soc Physiol

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show abstract

“…Similar results were also found by researchers, where the relationship between serum amylase and duration of diabetes was statistically significant and amylase in type 2 diabetic subjects became more severely affected in long-standing cases of diabetes mellitus indicating that measuring serum amylase levels in diabetics may be used for understanding the progress of diabetes. 15 In this study, we compared serum amylase and fasting blood sugar to correlate islet and acinar cell linkage which significantly shows low serum amylase level in type 2 diabetic patients as compared to that of healthy controls. We also found significantly higher Fasting sugar in type 2 Diabetic mellitus as compared to controls.…”

Section: Discussionmentioning

confidence: 99%

The Status of Serum Amylase among type 2 Diabetes Patients in Pokhara

Subedi

Shrestha

Gurung

et al. 2020

jhas

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Introduction: Diabetes Mellitus has become one of the common metabolic disorders characterized by hyperglycemia, associated with deficiency or resistance to insulin and shows abnormality in exocrine activity of pancreas. Pancreas is mixed gland that is both an endocrine and an exocrine gland with clusters of endocrinal, islet cell dispersed among exocrine acinar cells. Defects in islets cells in diabetes effect the exocrine secretion of the pancreas. Methods: Hospital based case-control study was conducted. Total sample size was 388. Out of which 194 were known cases of type 2 diabetic patients attending Manipal Teaching Hospital for medical checkup whereas 194 were Non Diabetic individuals with age and sex matched. Self-administer question was used to collected data from case and control. Three ml fasting blood samples were collected and centrifuged. Serum amylase was analyzed by using a semi automated analyzer. All estimates data were analysis statistically by using SPSS 22.0 full version. Results: Serum amylase levels were found significantly low in diabetic patients as compared to the Non-Diabetic (r = -0.313, p-value <0.001). Similarly, present study also showed negative correlation between serum amylase levels and duration of diabetes with Non-Diabetic (r = -0.388, p <0.001). Status of serum amylase and fasting sugar level was found to different among age groups, sex and ethnic groups. Conclusions: The increasing in duration of diabetes decreases the level of serum amylase which suggests a possible exocrine-endocrine relationship in this disease. Similarly, the level of serum amylase and fasting blood sugar vary among age group, sex and ethnicity. Thus, measurement of serum amylase can be an additional informative parameter for the assessment of chronicity and progress of the illness as well as the response to therapy.

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“…It is upheld that the action of insulin is critical for the production of pancreatic amylase [30,31] as such the common etiology in these conditions may be depleted secretion of insulin from the pancreas [32]. Although some studies reported low amylase level in type II diabetes mellitus, attributing it to the decline in the trophic effect of insulin on the pancreatic acinar cells [33,34,35], others claimed existence of transient and acute increases (from several to ten times beyond the upper normal level) in serum amylase concentration as a result of destruction of acinar cells in the pancreas [36]. However, repeated acute pancreatitis may eventually results in exhausted acinar cells and restricted flow of enzymes from pancreas parenchyma into the circulation [37,38,39] leading to low serum amylase.…”

Section: Discussionmentioning

confidence: 99%

The Role of Serum Alpha-Amylase and Glycogen Synthase in the Anti-Diabetic Potential of Terminalia catappa Aqueous Leaf Extract in Diabetic Wistar Rats

Ben

Asuquo

Owu

2019

AJRIMPS

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Background: The endocrinal abnormalities in diabetes mellitus as one of the numerous metabolic disorders is associated with derangement in exocrine functions of the pancreas and ultimately influences blood glucose regulation. Aim: The study was aimed at assessing the role of alpha-amylase and glycogen synthase in anti-diabetic potential of Terminalia catappa in diabetic rats. Materials and Methods: Thirty five (35) Wistar rats were assigned to 5 groups of 7 animals each. Group 1 served as the control administered distilled water at 5ml/kg bodyweight and group 2 was a non diabetic group given orally, 130/kg body weight of aqueous leaf extract of Terminalia catappa. Groups 3, 4 and 5 received a single dose of 150mg/kg body weight of alloxan solution intraperitoneally to induce diabetes and rats with blood glucose levels ≥200mg/dl after 72 hours were considered diabetic. This was followed by oral administration of 5ml/kg bodyweight of distilled water, 130mg/kg body weight of Terminalia catappa leaf extract orally and subcutaneous administration of insulin, 0.75U/kg body weight to groups 3 (diabetic), 4(diabetic + extract) and 5 (diabetic + insulin) respectively. Results: The results showed significant (P<.05) increase in serum level of alpha-amylase and glycogen synthase in both non-diabetic extract treated and diabetic groups when compared to control. But these enzymes significantly (P<.05) reduced in diabetic extract and insulin treated groups when compared to the diabetic group. Conclusion: Therefore the hypoglycaemic potential of Terminalia catappa leaf extract could be attributed to its ability to reduce alpha-amylase level while lowered glycogen synthase might be secondary to reduction in blood glucose.

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Evaluation of Amylase Activity in Patients with Type 2 Daibetes Mellitus

Cited by 14 publications

References 20 publications

Serum amylase and lipase levels in type 2 diabetes mellitus

Serum amylase and lipase levels in type 2 diabetes mellitus

The Status of Serum Amylase among type 2 Diabetes Patients in Pokhara

The Role of Serum Alpha-Amylase and Glycogen Synthase in the Anti-Diabetic Potential of Terminalia catappa Aqueous Leaf Extract in Diabetic Wistar Rats

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