Serum amylase and lipase levels in type 2 diabetes mellitus

Tanvi, Noor E Jannat; Akhter, Qazi Shamima; Nahar, Sharmin; Sumi, Mahmuda Nasrin; Hosen, Mobarak

doi:10.3329/jbsp.v12i2.35422

Cited by 12 publications

(12 citation statements)

References 9 publications

(14 reference statements)

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“…Previous reports published alteration of serum pancreatic amylase and lipase enzymes in patients with T1DM and T2DM. 15 , 16 In our experiment, the serum levels of amylase and lipase in the treated groups dramatically modulated compared to the diabetic control group, which is in agreement with the previous studies. In summary, it seems that Actinomycetales species can have an improvement effect for attenuation of side effects in various diabetes complications.…”

Section: Discussionsupporting

confidence: 92%

The Beneficial Effects of Actinomycetales Immune Modulators in the Pancreas of Diabetic Rats

et al. 2020

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Purpose: Type 1 diabetes mellitus (T1DM) has dramatically increased in recent years, especially in young people, and limits the life quality of the patients involved. Thus, many researchers are performing extensive studies to find alternative treatments for DM. Methods: Here, we evaluated the improvement effects of the heat-killed Actinomycetales species, including Gordonia bronchialis , and Tsukamurella inchonensis in streptozotocin (STZ)- diabetic rats by biochemical, immunological, and histopathological examinations. Results: The present findings exhibited a dramatic and progressive alteration in the serum levels of interleukin-6 (IL-6), IL-10 and tumor necrosis factor-α (TNF-α) in the diabetic group, which were related to the blood glucose and insulin levels, oxidative stress defense (evaluated by TAC and MDA activities), and the pancreas biochemical indicators (such as amylase and lipase). More importantly, the present results were consistent with the histopathological findings, which included cellular degeneration, vascular congestion, hemorrhage, focal necrosis associated with mononuclear cell infiltration. Interestingly, all of the diabetic changes in the blood serum and tissues improved remarkably in the treated groups by Actinomycetales species. Conclusion: Surprisingly, most of the current diabetic complications effectively attenuated after oral administration of both Actinomycetales species, particularly with a high dose of T. inchonensis. Thus, it is concluded that the heat-killed Actinomycetales species can prevent and improve the progression of T1DM and its various complications profoundly.

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Section: Discussionsupporting

confidence: 92%

The Beneficial Effects of Actinomycetales Immune Modulators in the Pancreas of Diabetic Rats

et al. 2020

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“…Generally, lipase enzymes catalyse the hydrolysis of ester bonds of triglycerides, and elevated serum lipase activity is implicated in t2ds [ 45 ]. Using the ligand fishing technique, isovitexin was identified as a lipase enzyme inhibitor [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Abdulai

Kwofie

Gbewonyo

et al. 2021

The Scientific World Journal

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Background. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.

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“…Study reported that dietary fibre deficiency led to insulin‐resistant in humans (Jenkins et al., 2000). In the insulin‐resistant state, the pancreas exocrine acinar cells emerged atrophy and serum lipase levels decreased in humans (Tanvi et al., 2017). However, this mechanism is only our speculation and it needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Growth performance, digestive and absorptive capacity of on‐growing grass carp ( Ctenopharyngodon idellus ) fed with graded level of dietary fibre from soybean hulls

Shao

Feng

et al. 2020

Aquacult. Nutr.

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The present research evaluated the effects of graded levels of dietary fibre on growth, digestive and absorptive capacities, and the potential underlying mechanisms in on‐growing grass carp (Ctenopharyngodon idella). Grass carp (123.00 ± 0.70 g) were fed diets with graded levels of neutral detergent fibre (NDF: 97.8, 119.0, 140.2, 159.4, 181.2 and 201.6 g/kg diet) for 60 days. Besides, a 2‐week digestion experiment was conducted to explore the effect of dietary fibre on the apparent digestibility coefficients (ADC) of feed. The results showed that optimum dietary fibre level (140.2 or 159.4 g/kg diet) increased feed intake, per cent weight gain, specific growth rate and the ADC of dietary protein (p < .05); increased the activities of digestive and brush border enzyme; and up‐regulated intestinal amino acid transporter mRNA levels (SLC1A5 and SLC6A19b, p < .05) partially associated with activation of TOR signalling pathway. However, high dietary fibre levels (NDF levels ≥181.2 g/kg diet) were not conducive to the digestion and absorption of nutrients, resulting in the decline of growth performance. Thus, based on the quadratic regression analysis for per cent weight gain and feed efficiency, the optimum (143.9 and 134.5 g/kg diet) and maximum tolerance (189.8 and 171.2 g/kg diet) levels of dietary NDF were estimated for on‐growing grass carp.

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Serum amylase and lipase levels in type 2 diabetes mellitus

Cited by 12 publications

References 9 publications

The Beneficial Effects of Actinomycetales Immune Modulators in the Pancreas of Diabetic Rats

The Beneficial Effects of Actinomycetales Immune Modulators in the Pancreas of Diabetic Rats

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Growth performance, digestive and absorptive capacity of on‐growing grass carp ( Ctenopharyngodon idellus ) fed with graded level of dietary fibre from soybean hulls

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