Evaluation of Age-Related Hearing Loss

Kim, Tae Su; Chung, Jong Woo

doi:10.7874/kja.2013.17.2.50

Cited by 33 publications

(38 citation statements)

References 13 publications

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“…A common type of sensorineural hearing loss is age-related hearing loss (ARHL), which occurs progressively in individuals as they age. 2 Despite its high prevalence and cost, there are no interventions that prevent ARHL.…”

Section: Introductionmentioning

confidence: 99%

Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome

et al. 2020

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Age-related hearing loss (ARHL) is one of the most common disorders affecting elderly individuals. There is an urgent need for effective preventive measures for ARHL because none are currently available. Cockayne syndrome (CS) is a premature aging disease that presents with progressive hearing loss at a young age, but is otherwise similar to ARHL. There are two human genetic complementation groups of CS, A and B. While the clinical phenotypes in patients are similar, the proteins have very diverse functions, and insight into their convergence is of great interest. Here, we use mouse models for CS (CSA −/− and CSB m/m ) that recapitulate the hearing loss in human CS patients. We previously showed that NAD + , a key metabolite with various essential functions, is reduced in CS and associated with multiple CS phenotypes. In this study, we report that NAD + levels are reduced in the cochlea of CSB m/m mice and that short-term treatment (10 days) with the NAD + precursor nicotinamide riboside (NR), prevents hearing loss, restores outer hair cell loss, and improves cochlear health in CSB m/m mice. Similar, but more modest effects were observed in CSA −/− mice. Remarkably, we observed a reduction in synaptic ribbon counts in the presynaptic zones of inner hair cells in both CSA −/− and CSB m/m mice, pointing to a converging mechanism for cochlear defects in CS. Ribbon synapses facilitate rapid and sustained synaptic transmission over long periods of time. Ribeye, a core protein of synaptic ribbons, possesses an NAD (H) binding pocket which regulates its activity. Intriguingly, NAD + supplementation rescues reduced synaptic ribbon formation in both CSA −/− and CSB m/m mutant cochleae. These findings provide valuable insight into the mechanism of CS-and ARHL-associated hearing loss, and suggest a possible intervention.npj Aging and Mechanisms of Disease (2020) 6:1 ; https://doi.

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Section: Introductionmentioning

confidence: 99%

Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome

et al. 2020

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“…Nevertheless, several studies suggest that the combination of hearing loss and visual impairment increases the risk of reduced function in daily life instrumental activities and produces more depression compared with having either condition. [28][29][30] Older adults with concomitant best-corrected visual impairment and mild hearing loss at baseline had a 2-fold increased risk of experiencing two or more falls five years later, 31 and dual sensory impairment is associated with lower health status and increased risk of mortality. 24,25 In contrast, some reports suggest that the main impact is caused by visual impairment, while hearing impairment alone does not further reduce functioning.…”

Section: Discussionmentioning

confidence: 99%

Self-reported hearing loss and visual impairment in adults from Central Mexico

et al. 2019

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ResumenObjetivo. Determinar la prevalencia de discapacidad auditiva (DA) y visual (DV) en adultos del estado de Tlaxcala, México. Material y métodos. Estudio transversal de base poblacional realizado en 2013 que incluye sujetos ≥50 años de edad. La DA se evaluó por autorreporte con el cuestionario Hearing Impairment Inventory for the Elderly (SHIIE); la DV se midió usando la cartilla E rotatoria de Snellen. Resultados. Se evaluaron 900 mujeres y 611 hombres (media=66.1 años). El 31.8% (481) tenía DA (415 sola y 66 con DV). La prevalencia de DA sola o con DV se asoció con edad (por cada dos años, RM=1.03 y RM=1.18, respectivamente) y con autorreporte del estado de salud deficiente (RM=1.90 y RM=3.69, respectivamente). Conclusiones. Se requiere la implementación de intervenciones en salud pública que reduzcan el impacto de estas dos condiciones en la población.Palabras clave: pérdida auditiva; trastornos de la visión; prevalencia Abstract Objective. To determinate the prevalence of hearing loss (HL) and visual impairment (VI) among adult population from Tlaxcala, Mexico. Materials and methods. A populationbased cross-sectional study comprising persons 50 years and older was conducted in 2013. Self-reported HL was measured using the Hearing Impairment Inventory for the Elderly (SHIIE) questionnaire; VI was determined using the Snellen tumbling E chart. Results. 900 women and 611 men (mean age 66.1 years) were included. 481(31.8%) individuals had HL (415 alone and 66 combined with VI). Prevalence of HL alone and together with VI was associated with age (per two years, OR=1.03 and OR=1.18, respectively) and self-reported poor health status (OR=1.90 and OR=3.69, respectively). Conclusion. The high prevalence of these disabilities calls for the implementation of public health interventions that help to reduce its impact in the population.

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“…A instalação gradual faz com que o idoso demore a perceber que está com perda auditiva, mas pode comprometer, desde o início, a inteligibilidade da fala nas situações sociais. Dessa forma, o convívio social torna-se cada vez mais difícil e pode originar isolamento social (GRECO; RUSSO, 2006, KIM;CHUNG, 2013).…”

Section: Discussionunclassified

“…Envelhecer no Brasil ainda significa um aumento no número de doenças crôni-cas (DANIELEWICZ; BARBOSA; DEL DUCA, 2014). Das alterações sensoriais sofridas por esses indivíduos, a diminuição da acuidade auditiva representa uma das principais causas de isolamento social, configurando-se como a alteração que produz maior impacto na comunicação e na vida psicossocial, podendo levar também à ansiedade, à depressão e à privação das atividades de vida diária do idoso (NOBREGA, CÂMARA, BORGES, 2008, KIM;CHUNG, 2013).…”

Section: Introductionunclassified

Estudo sobre a audição em idosos e associação com sintomatologia depressiva

Etcheverria

Prediger

Bauer

et al. 2015

Revista Brasileira De Ciências Do Envelhecimento Humano

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A perda auditiva representa uma das principais causas de isolamento social nos idosos e pode levar à depressão. O objetivo deste estudo foi verificar a existência de associação entre a presença e o grau de perda auditiva e sintomatologia depressiva em um grupo de idosos, bem como analisar a associação entre essas duas variáveis e a influência da idade e do sexo. Foram avaliados indivíduos idosos, por meio de audiometria tonal liminar, com pesquisa de limiares tonais por via aérea e via óssea, para verificação da presença, tipo e grau de perda auditiva. A avaliação também incluiu a aplicação da escala de depressão geriátrica (GDS) para observar a presença de sintomatologia depressiva. Fizeram parte da amostra 96 idosos, sendo 74 (77,1%) do sexo feminino, com idades entre 61 e 90 anos (média de 72,1±7,2 anos). Verificou-se presença de perda auditiva em 64 (66,7%) idosos, com predomínio de perda auditiva leve e moderada. Quanto à sintomatologia depressiva, essa foi observada em 22 (22,9%) idosos. Não foi observada associação entre a presença e o grau de perda auditiva e sintomatologia depressiva. Houve associação entre a perda auditiva e a idade. Concluiu-se que a maior parte dos idosos apresentou perda auditiva de grau leve a moderado. A sintomatologia depressiva foi detectada em um número menor de indivíduos e não houve associação entre perda auditiva e sintomatologia depressiva. A idade exerceu influência sobre a presença de perda auditiva. Não houve associação entre o sexo, a perda auditiva e a sintomatologia depressiva.Palavras-chave: Perda Auditiva. Depressão. Envelhecimento.

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Evaluation of Age-Related Hearing Loss

Cited by 33 publications

References 13 publications

Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome

Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome

Self-reported hearing loss and visual impairment in adults from Central Mexico

Estudo sobre a audição em idosos e associação com sintomatologia depressiva

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