Evaluation of adverse effects of lisinopril and rosuvastatin on hematological and biochemical analytes in wistar rats

Abstract

Objective:Combination therapy of lisinopril and rosuvastatin may be an important concept in developing more effective strategies to treat and prevent atherosclerosis, coronary heart disease, and co-morbid metabolic disorders. The present study was designed to evaluate toxic effects of lisinopril and rosuvastatin alone or its combination therapy on hematological and biochemical analytes in Wistar rats.Materials and Methods:Forty-two rats were divided into seven groups, with each group comprising six rats. Rats were administered with lisinopril, rosuvastatin alone, or in-combination at two different doses. The blood samples were collected from rats after 21 days of oral administration of the drug/s and analyzed for various hematological and biochemical analytes.Results:Lisinopril alone and its combination treatment with rosuvastatin at high doses decreased hemoglobin and hematocrit. Rosuvastatin alone at high dose and its concomitant administration with lisinopril at two different doses showed increase in total white blood cells and absolute lymphocyte count and neutrophil count. Serum levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin were significantly increased in rosuvastatin alone and its combination with lisinopril at both the doses. Besides this, lisinopril treatment decreased serum levels of sodium and increased the levels of potassium. Serum creatine kinase (CK) levels were increased in the animals treated with rosuvastatin at both the doses. However, increased serum CK level because of rosuvastatin became normal with co-administration of lisinopril at low doses.Conclusion:Our results indicate that administration of lisinopril with rosuvastatin does not ameliorate hepatotoxicity caused by rosuvastatin. However, combination treatment reduces serum CK levels elevated due to rosuvastatin, implicating protective effect of combination treatment on myopathy at low doses.

Comparative Effect of Lisinopril and Amlodipine with Moringa Oleifera on the Kidney Function of Dexamethasone and Salt-Induced Hypertensive Albino Rats

“…There was progressive increase in body weight from weeks 2-4 in Group III. This agrees with the report by [39], who observed weight gain in people taking Amlodipine; although it is rare and in contrast with the findings by [40], who observed that Lisinopril led to reduction in body weight. In Groups IV and V, there was increase in body weight in weeks 2 and 4 after treatment with Moringa oliefera had commenced.…”

Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

“…Although hepatocytes hold promising mechanisms for treating NAFLD, the medicine therapy seems necessary for the treatment of NAFLD, such as metformin, rosuvastatin, and pioglitazone [ 13 , 14 ]. However, most of the medicine has unwanted adverse effects [ 15 , 16 ] and limits its usage. Therefore, it is critical to find an affective therapeutic way with fewer side effects [ 16 ].…”

“…However, most of the medicine has unwanted adverse effects [ 15 , 16 ] and limits its usage. Therefore, it is critical to find an affective therapeutic way with fewer side effects [ 16 ]. Nonpharmaceutical therapy has become a new trend for the therapy of NAFLD [ 17 ].…”