Evaluation of adjuvant activity of Astragaloside VII and its combination with different immunostimulating agents in Newcastle Disease vaccine

Yakuboğulları, Nilgün; Coven, Furkan Ozan; Cebi, Nusin; Çöven, Fethiye; Çöven, Nejdet; Genç, Rükan; Bedіr, Erdal; Nalbantsoy, Ayşe

doi:10.1016/j.biologicals.2021.01.005

Cited by 10 publications

(8 citation statements)

References 36 publications

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“…In addition, a combination of adjuvants usually yield better immune responses than either adjuvant component alone; reduce dose of individual adjuvant component and frequency of immunizations; and may induce humoral immune response and cellular immune response ( 19 ). It was proven that the involvement of AST in oil adjuvant production was beneficial in improving the immune response ( 20 ).Therefore, AST were used as an immunopotentiator to improve the efficacy of a single dose of PRV inactivated vaccine in this study.…”

Section: Discussionmentioning

confidence: 92%

A single dose of Astragalus saponins adjuvanted inactivated vaccine for pseudorabies virus protected mice against lethal challenge

Chang

Wang²,

Hua³

et al. 2022

Front. Vet. Sci.

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Pseudorabies (PR) is an important infectious disease of swine that causes enormous economic losses to the swine industry in China. Immunization with vaccines is a routine practice to control this disease. PRV inactivated vaccines usually require a booster vaccination to provide complete immune protection. Therefore, Astragalus saponins (AST) have been added as an immunopotentiator to improve the immune efficacy and reduce the immunization times for the PRV inactivated vaccine. The results in mice have shown that a single dose of AST-adjuvanted PRV inactivated vaccine promoted higher production of gB-specific IgG, IgG1, and IgG2a and neutralizing antibody, secretion of Th1-type (IFN-γ) and Th2-type (IL-4) cytokines, and lymphocyte proliferation than mice immunized without AST. Compared to mice immunized without AST, a single dose of the AST-adjuvanted PRV inactivated vaccine improved the survival percentage of mice and reduced the PRV viral loads in the lungs and brains after lethal challenge. In summary, AST was an effective immunopotentiator to improve the immune efficacy of a single dose PRV inactivated vaccine.

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Section: Discussionmentioning

confidence: 92%

A single dose of Astragalus saponins adjuvanted inactivated vaccine for pseudorabies virus protected mice against lethal challenge

Chang

Wang²,

Hua³

et al. 2022

Front. Vet. Sci.

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“…Promoting the maturation and activation of APCs such as macrophages or dendritic cells [34,35]; Enhancing the levels of antigen-specific antibodies enhances the body's immune defense against antigens [35][36][37];…”

Section: Macrophyllosaponin B (12)mentioning

confidence: 99%

Potential Immunoregulatory Mechanism of Plant Saponins: A Review

Shen,

Luo,

Fan

et al. 2023

Molecules

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Saponins are extracted from different parts of plants such as seeds, roots, stems, and leaves and have a variety of biological activities including immunomodulatory, anti-inflammatory effects, and hypoglycemic properties. They demonstrate inherent low immunogenicity and possess the capacity to effectively regulate both the innate and adaptive immune responses. Plant saponins can promote the growth and development of the body’s immune organs through a variety of signaling pathways, regulate the activity of a variety of immune cells, and increase the secretion of immune-related cytokines and antigen-specific antibodies, thereby exerting the role of immune activity. However, the chemical structure of plant saponins determines its certain hemolytic and cytotoxicity. With the development of science and technology, these disadvantages can be avoided or reduced by certain technical means. In recent years, there has been a significant surge in interest surrounding the investigation of plant saponins as immunomodulators. Consequently, the objective of this review is to thoroughly examine the immunomodulatory properties of plant saponins and elucidate their potential mechanisms, with the intention of offering a valuable point of reference for subsequent research and advancement within this domain.

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“…Based on the promising immunostimulant effect comparable to commercialized adjuvants Alum and Quillaja saponins (including QS-21) 1 , 2 , 3 , our team has been prompted to carry out advance studies for developing Astragaloside VII (AST VII) ( Fig. 1 ) as a new vaccine adjuvant or an immunotherapeutic agent.…”

Section: Acknowledgmentmentioning

confidence: 99%