Evaluation of adenosine deaminase activity in patients with head and neck cancer

Dasmahapatra, Kumar S.; Hill, Helene Z.; Dasmahapatra, Amita; Suárez, Sara Busto

doi:10.1016/0022-4804(86)90201-5

Cited by 19 publications

(15 citation statements)

References 24 publications

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“…In contrast to these findings, ADA levels were depressed in cancerous laryngeal tissues [13] , low lymphocyte ADA activities were found in head and neck cancers [14] , and low salivary activities of ADA in patients with oral cancer [36] were observed.…”

Section: Discussioncontrasting

confidence: 46%

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Serum Adenosine Deaminase Levels in Pancreatic Diseases

İbi̇ş

Köklü²,

Yılmaz³

et al. 2007

Pancreatology

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Section: Discussioncontrasting

confidence: 46%

“…ADA activity is increased in diseases characterized by T-lymphocyte proliferation [5] and it is a nonspecific marker of T-cell activation. ADA plays an important role in many immunity-mediated diseases, and contradictory results have been reported regarding ADA levels in malignancies [6][7][8][9][10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Serum Adenosine Deaminase Levels in Pancreatic Diseases

İbi̇ş

Köklü²,

Yılmaz³

et al. 2007

Pancreatology

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“…ADA enzyme activities in head and neck cancer tissues have presented controversial results in literature review [15][16][17][18][19]. Altered purine metabolism in various cancer types which is affected actively by genetic alterations may be one of the reasons for this discrepancy [20].…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer

Ant¹,

İnal

Avcı

et al. 2017

The European Research Journal

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Objective. Inflammation and oxidative stress are considered as the main pathways in oral cavity carcinoma. The aim of this study was to evaluate the activity levels of adenosine deaminase (ADA), nitric oxide (NO), nitric oxide synthase (NOS), and xanthine oxidase (XO) in oral cavity carcinoma, to determine their potential roles in carcinogenesis with relation to oxidative stress. Methods. Seventeen patients with oral cavity cancer underwent surgery as the primary therapy, were consisted in the study. Resected oral cavity carcinoma tissues were compared with the adjacent tumor-free control tissues of the same patients; ADA, NO, NOS, XO activity levels were evaluated in terms of difference. Results. There is a significant increase of ADA activity in squamous cell cancer tissues, which indicates a difference between the normal and tumor tissues at enzyme levels (p<0.001). Conclusion. Elevated ADA activity might be an attempt to supress formation of the immunosupressed niche which promotes the onset of neoplasia and/or to inhibit tumor progression and metastasis.

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“…Binding of ADA to CD26 is capable of reducing the local concentration of adenosine and has an enzymatic role in protecting T cells from an adenosine-mediated inhibition of proliferation [44, 45]. Indeed, it has been reported that adenosine deaminase activity is significantly lower in the peripheral lymphocytes of cancer patients, suggesting increased susceptibility of T cells to adenosine-mediated inhibition within the tumour microenvironment [46]. Moreover, cytotoxic T cells show very low levels of adenosine deaminase activity, leaving us to hypothesize that cytotoxic cells would be quite sensitive to the immune inhibitory effect of adenosine accumulated within tumours.…”

Section: Adenosine Inhibits Killer T Cell Activation Via A3 and A2a Smentioning

confidence: 99%

Adenosine and lymphocyte regulation

Gessi

Varani

Merighi

et al. 2007

Purinergic Signalling

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Adenosine is a potent extracellular messenger that is produced in high concentrations under metabolically unfavourable conditions. Tissue hypoxia, consequent to a compromised cellular energy status, is followed by the enhanced breakdown of ATP leading to the release of adenosine. Through the interaction with A2 and A3 membrane receptors, adenosine is devoted to the restoration of tissue homeostasis, acting as a retaliatory metabolite. Several aspects of the immune response have to be taken into consideration and even though in general it is very important to dampen inflammation, in some circumstances, such as the case of cancer, it is also necessary to increase the activity of immune cells against pathogens. Therefore, adenosine receptors that are defined as ‘sensors–of metabolic changes in the local tissue environment may be very important targets for modulation of immune responses and drugs devoted to regulating the adenosinergic system are promising in different clinical situations.

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Evaluation of adenosine deaminase activity in patients with head and neck cancer

Cited by 19 publications

References 24 publications

Serum Adenosine Deaminase Levels in Pancreatic Diseases

Serum Adenosine Deaminase Levels in Pancreatic Diseases

Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer

Adenosine and lymphocyte regulation

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