Evaluation of acute phase proteins and cytokines in dogs with parvoviral enteritis

Ok, Mahmut; Er, Cenk; Yıldız, Ramazan

doi:10.15312/eurasianjvetsci.2015310970

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Furthermore, the distribution of SAA concentrations showed a narrow range of measured values suggesting a strong systemic inflammatory response in all the evaluated dogs. Although significantly higher SAA values in dogs suffering from parvoviral enteritis in comparison to control animals were observed also by Ok et al (2015), the differences were less marked compared to our results (approximately 2-fold higher). C-reactive protein has been found by Yamamoto et al (1993) and Kocaturk et al (2010) to be more markedly increased in canine parvoviral enteritis with more than 70-fold higher values in severely affected animals with leukopenia compared to healthy dogs.…”

Section: Discussioncontrasting

confidence: 95%

Evaluation of Acute Phase Proteins in Dogs Suffering from Various Diseases

2022

Int J Vet Sci

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The proteins of acute phase response are sensitive markers of ongoing inflammatory processes also in dogs with increased production in many infections and organ diseases. However, the magnitude and intensity of increase in their concentrations may differ according to the type of injury or the causative agent of the disease which is not completely understood. Therefore, this study was conducted to determine major acute phase proteins (APP) concentrations in dogs with selected diseases and to compare the values among the various groups of dogs. The study was conducted on serum samples from 89 client-owned dogs with the following diseases: dogs with parvoviral enteritis (n=14), pyometra (n=21), acute pancreatitis (n=14), and babesiosis (n=39). Clinically healthy dogs (n=23) without any abnormal clinical conditions were also included in the study. The concentrations of serum amyloid A (SAA), haptoglobin (Hp), and C-reactive protein (CRP) were analysed in blood serum. The concentrations of all the evaluated APPs differed significantly between the groups of dogs (P<0.001). Although the average concentrations of all parameters were higher in diseased dogs compared to healthy animals, the magnitude of increase differed among the disease groups. Canine parvoviral enteritis and pyometra induced the most marked inflammatory response with the highest mean concentrations of SAA, Hp, and CRP. On the other hand, canine babesiosis was associated with less marked alterations among the evaluated diseases of dogs. The obtained data indicated that the investigated canine disorders were associated with different inflammatory responses, characterized by marked and significant differences in the assessed acute phase reactants.

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Section: Discussioncontrasting

confidence: 95%

Evaluation of Acute Phase Proteins in Dogs Suffering from Various Diseases

2022

Int J Vet Sci

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Evaluation of qSOFA and variation of hematochemical profile in cats naturally infected with feline panleukopenia virus

Gülersoy

Erol

et al. 2023

Open Veterinary Science

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Feline panleukopenia (FP) is a fatal viral disease that predisposes cats to sepsis and organ failure. Owing to a wide variety of clinical findings, hematochemical examinations are significant for the determination of early signs of disease-related complications. The aim of this study is to investigate the diagnostic efficacy of certain hematochemical parameters together with quick Sepsis-related Organ Failure Assessment (qSOFA) in cats with FP. A total of 10 healthy and 30 panleukopenic cats were included in this study. Physical examinations revealed that the body temperature was highest in septic panleukopenic cats (p < 0.009) and they had higher qSOFA scores (p = 0.000). Hemogram analysis revealed that leukocyte, lymphocyte, granulocyte, erythrocyte, and hemoglobin levels were lower in non-septic panleukopenic cats compared with the healthy ones (p < 0.030). Also, monocyte and mean corpuscular hemoglobin levels were lower in septic ones (p < 0.048). Serum biochemistry profiling revealed higher blood urea nitrogen, creatinine, alanine aminotransferase, lactate dehydrogenase, total bilirubin, and C-reactive protein levels in panleukopenic cats (p < 0.033). As a result, it was concluded that although the qSOFA is not sufficient to distinguish sepsis in cats, unlike dogs, in order to achieve a positive clinical outcome, when evaluated together with hematochemical variables, it may help in making early diagnosis of FP-related complications.

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