Evaluation of acute kidney injury (AKI) with RIFLE, AKIN, CK, and KDIGO in critically ill trauma patients

Ülger, Fatma; Küçük, Mehtap Pehlivanlar; Küçük, Ahmet; İlkaya, Nazan Köylü; Murat, Naci; Bilgiç, Büşra; Abanoz, H

doi:10.1007/s00068-017-0820-8

Cited by 33 publications

(41 citation statements)

References 30 publications

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“…For the diagnosis of postoperative AKI, we employed the criteria and grading system laid out in the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines [ 10 ] because the KDIGO classification is recognized as the most adequate tool for this purpose [ 11 , 12 ]. Specifically, AKI diagnosis was based only on creatinine levels (Additional file 1 ).…”

Section: Methodsmentioning

confidence: 99%

Hyperchloremia and postoperative acute kidney injury: a retrospective analysis of data from the surgical intensive care unit

Song

Kim

et al. 2018

Crit Care

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BackgroundWhether perioperative hyperchloremia can induce postoperative acute kidney injury (AKI) is controversial. We investigated the association between perioperative hyperchloremia and postoperative AKI in patients admitted to the intensive care unit (ICU) after surgery.MethodsWe performed a retrospective observational study of patients admitted to the surgical ICU at a single tertiary care hospital between January 2011 and June 2016. Our primary objective was to determine whether hyperchloremia or an increase in serum chloride levels was associated with postoperative AKI. Perioperative hyperchloremia was defined as serum chloride levels ≥ 110 mmol·L− 1 during postoperative days (PODs) 0–3. The increase in serum chloride levels was defined as the difference between preoperative and maximum postoperative serum chloride levels during the first 3 days after surgery.ResultsOf the 7991 patients included in the final analysis, 1876 (23.5%) developed hyperchloremia during PODs 0–3, and 1187 (14.9%) developed postoperative AKI. Exposure to hyperchloremia during the first 3 days after surgery was not associated with postoperative AKI (odds ratio, 1.09; 95% confidence interval, 0.80–1.49; P = 0.571). However, among patients with preoperative chronic kidney disease stage ≥ 3 (estimated glomerular filtration rate < 60 mL·min− 1·1.73·m− 2), the incidence of postoperative AKI was higher in patients with an increase > 6 mmol·L− 1 in serum chloride levels than in patients with an increase ≤ 1 mmol·L− 1 (odds ratio, 1.42; 95% confidence interval, 1.09–1.84; P = 0.009). In addition, the incidence of postoperative AKI stage ≥ 2 was not associated with exposure to hyperchloremia or with the increase in serum chloride levels during PODs 0–3, regardless of preoperative kidney function.ConclusionsExposure to perioperative hyperchloremia is not associated with postoperative AKI in surgical ICU patients. However, in patients with moderate-to-severe chronic kidney disease (stage ≥ 3), a substantial perioperative increase in serum chloride levels may reflect a higher risk of AKI.Electronic supplementary materialThe online version of this article (10.1186/s13054-018-2216-5) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Hyperchloremia and postoperative acute kidney injury: a retrospective analysis of data from the surgical intensive care unit

Song

Kim

et al. 2018

Crit Care

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“…Preliminary findings have shown that the etiology and prevalence of AKI vary, mainly due to different aspects of the sample evaluated (i.e., animal species, sex, age, and comorbidity), differences in the income levels of countries (with low-to-middle income countries showing more severity and a higher incidence of AKI than high-income countries), and differences in AKI classification criteria [32,38,43,44]. Throughout the last two decades, the AKI definition has been mainly based on the RIFLE (Risk, Injury, Failure, Loss, End-Stage Kidney Disease), Acute Kidney Injury Network (AKIN), and Kidney Disease: Improving Global Outcomes (KDIGO) criteria and stages [43,44]. Until 2004, the diagnosis of AKI was based on urine output as well as blood urea nitrogen (BUN) and serum creatinine (SCr) levels.…”

Section: General Aspects Of Acute Kidney Injurymentioning

confidence: 99%

“…RIFLE uses glomerular filtration rate (GFR) criteria in addition to SCr and urine output criteria. The Risk, Injury, and Failure stages were determined by increases in SCr ≥ 1.5-, 2-, and 3-fold from a known baseline, respectively [43][44][45]. In 2007, the Acute Kidney Injury Network (AKIN) definitions were created with criteria driven by observations of minor increases in SCr over a shorter time period (48 h).…”

Section: General Aspects Of Acute Kidney Injurymentioning

confidence: 99%

Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury

Diniz¹,

Souza

Duarte

et al. 2020

Molecules

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The inflammatory mediator and oxidant agent storm caused by the SARS-CoV-2 infection has been strongly associated with the failure of vital organs observed in critically ill patients with coronavirus disease 2019 (COVID-19) and the death of thousands of infected people around the world. Acute kidney injury (AKI) is a common renal disorder characterized by a sudden and sustained decrease in renal function with a critical influence on poor prognosis and lethal clinical outcomes of various etiologies, including some viral infection diseases. It is known that oxidative stress and inflammation play key roles in the pathogenesis and development of AKI. Quercetin is a natural substance that has multiple pharmacological properties, such as anti-inflammatory action, and is used as a dietary supplement. There is evidence of the anti-coronavirus activities of this compound, including against the target SARS-CoV-2 3CLpro. The ability to inhibit coronavirus and its inflammatory processes is strongly desired in a new drug for the treatment of COVID-19. Therefore, in this review, the dual effect of quercetin is discussed from a mechanistic perspective in relation to AKI kidney injury and its nephroprotective potential to SARS-CoV-2 patients.

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“…No Ceará, em estudo realizado em unidade de terapia intensiva na cidade de Sobral, foi identificada prevalência de LRA de 28,6%, além de aumento da mortalidade nos indivíduos acometidos (SANTOS et al, 2015). (BAITELLO et al, 2013;OSTERMANN e JOANNIDIS, 2016;SCHMIDT et al, 2016;ÜLGER et al, 2018).…”

Section: Metodologiaunclassified

“…Nessa perspectiva, apesar de a LRA ser um fator de risco independente para mortalidade em pacientes graves, os pacientes politraumatizados estão expostos a diversas outras condições de risco, como inflamação sistêmica, choque hipovolêmico, transfusão sanguínea, rabdomiólise, síndrome compartimental abdominal, cirurgias de alta complexidade, lesão de isquemia-reperfusão e dano renal direto (PODOLL et al, 2013;ERIKSSON et al, 2015;LAI et al, 2016;ÜLGER et al, 2018). Assim, alguns cuidados intensivos, a exemplo da interrupção de hemorragias e da reposição volêmica, podem contribuir com a prevenção da LRA nesses indivíduos (HARROIS et al, 2017).…”

Section: Metodologiaunclassified

Experiências De Educação Permanente Em Saúde Na Atenção Básica: Revisão Integrativa Da Literatura

Moraes¹,

Moraes²,

Higa³

2020

Propostas, Recursos E Resultados Nas Ciências Da Saúde 4

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Evaluation of acute kidney injury (AKI) with RIFLE, AKIN, CK, and KDIGO in critically ill trauma patients

Cited by 33 publications

References 30 publications

Hyperchloremia and postoperative acute kidney injury: a retrospective analysis of data from the surgical intensive care unit

Hyperchloremia and postoperative acute kidney injury: a retrospective analysis of data from the surgical intensive care unit

Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury

Experiências De Educação Permanente Em Saúde Na Atenção Básica: Revisão Integrativa Da Literatura

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