Evaluation of acrosome intactness status in male infertility in Mysore, South India

Sreenivasa, G; Vineeth, Venugopal Satidevi; Kavitha, P; Malini, Suttur v

doi:10.4103/2229-516x.96801

Cited by 3 publications

(2 citation statements)

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“…Furthermore, the specific interest in acrosome reaction cannot be treated because of homeostasis imbalance caused by ROS of oxidative stress. [23][24][25] The acrosome portion of spermatozoa is sensitive and easily damaged, even at slightly higher temperatures. Mostafa describes how oxidative stress-induced free radicals from smoking cause chromosome abnormalities spermatogenesis, physiology leads to poor motility and impaired morphology.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Cigarette Smoke-induced Biophysical ROS on Spermatozoa Heads and Telomere Shortening in Infertile Smokers: A Prospective Study

Rao,

Sridharan,

Ranganathan

2023

International Journal of Infertility &Amp; Fetal Medicine

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According to a recent study, cigarette smoking affects sperm motility, morphology, and homeostasis by causing damage to the sperm head and tail. This is a common misconception. 12 Meanwhile, reproductive toxicants such as cadmium (Cd), lead, IntroductIonInfertility is a couple's inability to conceive a pregnancy after a year of regular unprotected sexual intercourse. Furthermore, "male infertility" refers to the physical inability to produce healthy sperm and achieve pregnancy with a healthy female after 1 year of abstinence. 1 Male infertility is caused by a variety of factors. 2 According to previous reports, among all the smoking and smoking-related health issues, there is an alarmingly high suspicion regarding male infertility. 3 A total of 36.9% of the world's population is addicted to tobacco and tobacco-related cigarette components. According to research, smoking causes nearly 40-50% of respiratory and cardiac problems. 4 Meanwhile, the World Health Organization (WHO) reported that smoking is responsible for 15-30% of all reproductive problems. 5,6 Cigarette smoking has now been identified as an attractive and intriguing habit in adolescents aged 15-19. Furthermore, the dominance of psychoactive drugs or the substantial presence of cigarette inhalation causes addiction. 7 According to new research, cigarette smoking is not the only cause of the progression of various cancers and cardiovascular and pulmonary damage. It also plays a role in fertility issues in men who smoke more [as measured by the smoking index (SI)]. [8][9][10] Cigarette smoke contains over 2000 chemicals, including 40 toxic metal substances, and smokers are exposed to smoke. 11

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Section: Discussionmentioning

confidence: 99%

The Effects of Cigarette Smoke-induced Biophysical ROS on Spermatozoa Heads and Telomere Shortening in Infertile Smokers: A Prospective Study

Rao,

Sridharan,

Ranganathan

2023

International Journal of Infertility &Amp; Fetal Medicine

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“…For instance, the acrosin content in the ejaculates of Patients 1, 5 and 6 decreases by a factor of 1.6-2.3 after the insertion of soot1 nanoparticles, which means that in nearly 30% of cases, this type of soot impedes the spontaneous acrosome reaction. As a result, preserving the acrosome intact prevents the loss of acrosomal enzyme activity during the bursting in the female genital tract of the cap-like structure covering the anterior portion of the sperm nucleus, thus increasing the chance for successful in-vitro fertilization [30].…”

Section: Effect Of Rapeseed Oil Soot On the Acrosome Reaction Of Huma...mentioning

confidence: 99%

Oxidative Stress and Acrosomal Status of Human Spermatozoa Subjected to Hydrophobic Carbon Soot Treatments

Esmeryan,

Rangelov,

Chaushev

2024

Nanomaterials

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The fourth industrial revolution extensively reshapes the reality we are living in by blurring the boundaries of physical, digital and biological worlds. A good example is the previously unthinkable incursion of nanoscale waste materials, such as soot, into the technologies for assisted reproduction. Although the rapeseed oil soot may efficiently enhance the progressive motility of human spermatozoa, it is yet unknown whether this material induces undesirable oxidative stress and premature acrosome reaction, endangering the sperm-oocyte fusion and blastocyst formation. In an attempt to clarify this issue, we reveal that the three-hour incubation of human semen mixed with three main types of soot does not cause oxidative stress and spontaneous acrosome reaction of the sperm. These unique findings are attributed to synchronous elimination and stabilization of the oxidants via hydrogen bonding to the acidic groups of the soot (i.e., C=O and/or C-O-C) and electron donation by its basic chemical sites (i.e., C-OH and/or COOH). Moreover, the soot nanoparticles are electrostatically attracted by discrete positively charged areas on the sperm head, increasing its negative charge and in some cases interfering the acrosome reaction. Such novel mechanistic insights emphasize the credibility of rapeseed oil soot to confidently shift from the purely diagnostic and therapeutic phases in reproductive medicine to research dealing with the effect of carbon nanomaterials on the embryo development and implantation.

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Effect of Storage Time on Cauda Epididymal Sperm Parameters of Nigerian Local Dogs

Chima¹,

Abu²,

Dawuda³

et al. 2017

OJVM

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Aim: Storage of testes-epididymides at refrigeration temperature is a promising method of short-term sperm preservation for use in reproductive biotechnology in dogs. This study aimed to determine the effect of storage time at 4˚C on the quality of Nigerian local dogs' cauda epididymal spermatozoa recovered post-castration. Materials and Methods: Testes along with their epididymides collected immediately after castration of local dogs were either processed immediately (0th hour) or stored at 4˚C in the refrigerator for 12th, 24th or 48th hours and then processed. Each storage group comprised 5 pairs of testes-epididymides. Sperm motility, concentration, livability, acrosome integrity and morphology from the various storage groups were evaluated and means with standard error of the mean (±SEM) were recorded. Results: Mean percent sperm motility at 0th hour (77.0 ± 2.6) decreased significantly (p < 0.05) after 12 hours (68.0 ± 1.2), 24 hours (66.0 ± 2.4) and 48 hours (60.0 ± 1.6) of storage at 4˚C. No significant difference (p > 0.05) was found when the mean sperm concentrations (×10 7 /ml) of the storage groups (5.86 ± 47, 5.24 ± 26 and 5.38 ± 31) were compared with the control (6.48 ± 0.75). Mean percent sperm livability did not differ significantly (p > 0.05) between the 0th, 12th, 24th and 48th hour groups (86.4 ± 1.5, 78.0 ± 3.1 and 75.0 ± 1.8 respectively). However, there was a significant decrease (p < 0.05) in mean percent sperm livability after 48 hours of storage (69.8 ± 4.2) as compared with the 0th hour group. No significant difference (p > 0.05) was detected in the mean percent acrosome integrity between the 0th, 12th, 24th and 48th hour groups (90.0 ± 1.5, 83.0 ± 3.5, 84.6 ± 4.6 and 82.2 ± 3.9 respectively). A significant increase (p

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Evaluation of acrosome intactness status in male infertility in Mysore, South India

Cited by 3 publications

References 8 publications

The Effects of Cigarette Smoke-induced Biophysical ROS on Spermatozoa Heads and Telomere Shortening in Infertile Smokers: A Prospective Study

The Effects of Cigarette Smoke-induced Biophysical ROS on Spermatozoa Heads and Telomere Shortening in Infertile Smokers: A Prospective Study

Oxidative Stress and Acrosomal Status of Human Spermatozoa Subjected to Hydrophobic Carbon Soot Treatments

Effect of Storage Time on Cauda Epididymal Sperm Parameters of Nigerian Local Dogs

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