Evaluation of acoustic radiation force impulse elastography for fibrosis staging of chronic liver disease: a pilot study

Takahashi, Kazuhiro; Ono, Naofumi; Eguchi, Yuichiro; Eguchi, Takahisa; Kitajima, Yoichiro; Kawaguchi, Yasunori; Nakashita, Shunya; Ozaki, Iwata; Mizuta, Toshihiko; Toda, Shuji; Kudo, Sho; Miyoshi, Anderson; Miyazaki, Kohji; Fujimoto, Kazuma

doi:10.1111/j.1478-3231.2009.02130.x

Cited by 209 publications

(175 citation statements)

References 48 publications

(63 reference statements)

Supporting

Mentioning

161

Contrasting

Order By: Relevance

“…The shear wave velocity (expressed in meters per second) is measured in a region of interest smaller than that of TE (10-mm long and 6-mm wide), but that can be chosen by the examiner. Preliminary results suggest that at least in patients with chronic hepatitis C, its performance is very similar to that of TE, although further validation is warranted [122][123][124][125][126]. The major advantage of this novel technology is that it can be easily implemented on a modified commercial ultrasound machine.…”

Section: Novel Imaging Techniquesmentioning

confidence: 99%

Non-invasive assessment of liver fibrosis in chronic hepatitis C

Castéra

2011

Hepatol Int

View full text Add to dashboard Cite

Section: Novel Imaging Techniquesmentioning

confidence: 99%

Non-invasive assessment of liver fibrosis in chronic hepatitis C

Castéra

2011

Hepatol Int

View full text Add to dashboard Cite

“…Recent studies have evaluated its use in the study of hepatic fibrosis in patients with chronic liver disease (viral in most cases), and the results have shown good concordance with histological data [24,25]. Takahashi et al, for example, found that liver stiffness measured with ARFI correlates with Metavir scores of liver fibrosis.…”

Section: Introductionmentioning

confidence: 97%

ARFI elastography in patients with chronic autoimmune liver diseases: A preliminary study

Righi

Fiorini

Molo

et al. 2012

Journal of Ultrasound

View full text Add to dashboard Cite

Objective: Acoustic radiation force impulse (ARFI) is a new software-based technique that evaluates liver stiffness during B-mode ultrasonography. The purpose of this study was to evaluate the accuracy of ARFI in distinguishing patients with chronic autoimmune liver disease from healthy subjects. Material and methods: We enrolled 9 adult patients (8 women, 1 man; age 48.1 AE 12.8 years) with chronic autoimmune disease (primary biliary cirrhosis (PBC, n Z 3), autoimmune hepatitis (AIH, n Z 2), primary sclerosing cholangitis (PSC, n Z 1) and overlap syndromes, (n Z 3) who underwent a liver biopsy and 11 healthy volunteers (age 34.7 AE 10.4 years; 7 women, 4 men). Liver stiffness was evaluated and expressed as the shear wave velocity (SWV) in m/sec. We used a US scanner Siemens-Acuson S2000, evaluating the right liver lobe and the left liver lobe. Results: The SWV was significantly higher in cases (right lobe: 1.51 AE 0.44; left lobe: 1.57 AE 0.40) than in controls (right lobe: 1.08 AE 0.10; left lobe: 1.12 AE 0.13) (right lobe: P Z 0.002; left lobe: P Z 0.013). We found no significant correlation between right and left lobe SWVs in cases (P Z 0.779) or controls (P Z 0.385). The SWV cut-off that best distinguished cases from controls was 1.25 m/sec (accuracy: AUCZ0.885; sensitivity: 70.6%; specificity: 95.5%). Conclusions: ARFI elastography is a noninvasive ultrasonographic technique that can differentiate healthy subjects from patients with fibrotic stages of chronic liver disease.Sommario Introduzione: L'elastografia ARFI è una tecnologia integrata all'ultrasonografia convenzionale B-mode in grado di determinare la rigidità tissutale. L'obiettivo di questo studio è stato valutare se l'elastografia ARFI sia in grado di differenziare pazienti affetti da patologie epatiche croniche autoimmuni e soggetti normali. Materiali e metodi: Sono stati arruolati 9 pazienti affetti da epatopatia cronica autoimmune sottoposti a biopsia epatica (età 48.1 AE 12.8 anni; femmine/maschi: 8/1; 3 PBC, 2 AIH, 1 PSC e 3 overlap) e 11 volontari sani (età 34.7 AE 10.4 anni; F/M: 7/4). La rigidità epatica è stata valutata mediante l'elastografia ARFI ed espressa come "shear wave velocity" (SWV) in m/sec. È stato utilizzato un ecografo Siemens-Acuson S2000 valutando entrambi i lobi epatici. Le * Corresponding author. Ospedale S. Orsola Malpighi, Via Massarenti, 9, St. Orsola Malpighi, Bologna, Italy.E-mail address: fiorini.erica@gmail.com (E. Fiorini). misurazioni sono state eseguite a respiro bloccato, ad una profondità compresa tra 2 e 5 cm. Risultati: La SWV è risultata significativamente più elevata nei casi (Dx: 1.51 AE 0.44; Sn: 1.57 AE 0.40) rispetto ai controlli (Dx: 1.08 AE 0.10; Sn: 1.12 AE 0.13) (Dx: P Z 0.002; Sn: P Z 0.013). Sia nei pazienti con epatopatia cronica (P Z 0.779) che nei controlli (P Z 0.385) non è stata rilevata una differenza statisticamente significativa della SWV fra i due lobi. Il valore ottimale di SWV per discriminare i casi dai controlli è risultato 1.25 m/sec (accuratezza: AUC Z 0.885; sensibilità...

show abstract

“…Preliminary study results indicate that the acoustic radiation force impulse (ARFI) elastography is a noninvasive method for measuring liver stiffness (LS) and can be used for the diagnosis of liver fibrosis and cirrhosis in chronic liver disease 17, 18, 19, 20, 21, 22, 23. However, the relationship between LS and its impact on the development of HCC remains unclear in chronic hepatitis C patients who achieved SVR following DAA therapy.…”

Section: Introductionmentioning

confidence: 99%

Liver stiffness measurement predicts hepatocellular carcinoma development in patients treated with direct‐acting antivirals

et al. 2017

View full text Add to dashboard Cite

Background and AimPredictive factors for hepatocarcinogenesis following eradication of hepatitis C virus by direct‐acting antivirals (DAAs) are unknown. The aim of the study was to investigate the relationships between liver stiffness (LS) using acoustic radiation force impulse (ARFI) erastograghy and the development of hepatocellular carcinoma (HCC) in patients who achieved sustained virological response (SVR) treated with DAA.MethodsIn this prospective study, we enrolled 263 hepatitis C patients with SVR who underwent ARFI before DAA treatment. Thirty patients had previous HCC.ResultsThe median LS value according to ARFI measurements was 1.34 m/s (range: 0.67–4.35). During the follow‐up period (median: 18.1 months), development of HCC occurred in 19 patients (7.2%; HCC occurrence in 7 patients and HCC recurrence in 12 patients). By multivariate Cox regression analysis, HCC history (hazard ratio [HR]: 10.634; 95% confidence interval [CI]: 4.13–27.37; P = 0.001), older age (HR: 4.638; 95% CI: 1.63–13.61; P = 0.004) and higher total bilirubin levels (HR: 4.189; 95% CI: 1.66–10.60; P = 0.002) were independent predictors for the development of HCC, and higher LS value (≥1.73 m/s) at baseline was an independent predictor for HCC occurrence (HR: 8.350; 95% CI: 1.62–43.09; P = 0.011). The cumulative recurrence of HCC was statistically similar according to the degree of LS in patients who were previously treated for HCC.ConclusionThe LS value at baseline is useful for predicting HCC occurrence. Thus, even if SVR is achieved, patients with higher LS at baseline must be followed carefully for HCC occurrence.

show abstract

Evaluation of acoustic radiation force impulse elastography for fibrosis staging of chronic liver disease: a pilot study

Abstract: Ultrasonic ARFI elastography is a novel, non-invasive and reliable method for the assessment of liver fibrosis in patients with chronic liver disease.

Cited by 209 publications

References 48 publications

Non-invasive assessment of liver fibrosis in chronic hepatitis C

Non-invasive assessment of liver fibrosis in chronic hepatitis C

ARFI elastography in patients with chronic autoimmune liver diseases: A preliminary study

Liver stiffness measurement predicts hepatocellular carcinoma development in patients treated with direct‐acting antivirals

Contact Info

Product

Resources

About