Evaluation of Accuracy and Precision of Manual Size Measurements in Chest Tomosynthesis using Simulated Pulmonary Nodules

Söderman, Christina; Johnsson, Åse A.; Vikgren, Jenny; Norrlund, Rauni Rossi; Molnár, Dávid; Svalkvist, Angelica; Månsson, Lars Gunnar; Båth, Magnus

doi:10.1016/j.acra.2014.11.012

Cited by 15 publications

(22 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the effect was largest for growths corresponding to a volume increase of up to 37%. Results from a previous study showed that the absolute intraobserver variability of nodule diameter measurements in chest tomosynthesis images were of similar magnitude for nodules ranging in diameter from approximately 4À12 mm (23). These results indicate that, for a given relative nodule volume increase, the detection rate of nodule growth will decrease with the nodule size but that the effect would decrease with increasing nodule growth.…”

Section: Discussionmentioning

confidence: 61%

Detection of Pulmonary Nodule Growth with Chest Tomosynthesis: A Human Observer Study Using Simulated Nodules

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 61%

Detection of Pulmonary Nodule Growth with Chest Tomosynthesis: A Human Observer Study Using Simulated Nodules

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Size estimation and, consequently, precision of size measurements is the main factor that decides whether a nodule should be recommended for follow-up. This study defines the reference truth regarding follow-up according to manual size measurements at CT. A previous study (36) reported variability in nodule size measurements up to 0.8 mm at DTS, and although Johnsson et al (37) found no evident bias between measurements of longest diameter at DTS…”

Section: Disclosures Of Conflicts Ofmentioning

confidence: 89%

Detection and Characterization of Solid Pulmonary Nodules at Digital Chest Tomosynthesis: Data from a Cohort of the Pilot Swedish Cardiopulmonary Bioimage Study

Meltzer¹,

Vikgren²,

Bergman³

et al. 2018

Radiology

Self Cite

View full text Add to dashboard Cite

Purpose To investigate the performance of digital tomosynthesis (DTS) for detection and characterization of incidental solid lung nodules. Materials and Methods This prospective study was based on a population study with 1111 randomly selected participants (age range, 50-64 years) who underwent a medical evaluation that included chest computed tomography (CT). Among these, 125 participants with incidental nodules 5 mm or larger were included in this study, which added DTS in conjunction with the follow-up CT and was performed between March 2012 and October 2014. DTS images were assessed by four thoracic radiologists blinded to the true number of nodules in two separate sessions according to the 5-mm (125 participants) and 6-mm (55 participants) cut-off for follow-up of incidental nodules. Pulmonary nodules were directly marked on the images by the readers and graded regarding confidence of presence and recommendation for follow-up. Statistical analyses included jackknife free-response receiver operating characteristic, receiver operating characteristic, and Cohen κ coefficient. Results Overall detection rate ranges of CT-proven nodules 5 mm or larger and 6 mm or larger were, respectively, 49%-58% and 48%-62%. Jackknife free-response receiver operating characteristics figure of merit for detection of CT-proven nodules 5 mm or larger and 6 mm or larger was 0.47 and 0.51, respectively, and area under the receiver operating characteristic curve regarding recommendation for follow-up was 0.62 and 0.65, respectively. Conclusion Routine use of DTS would result in lower detection rates and reduced number of small nodules recommended for follow-up. RSNA, 2018.

show abstract

“…However, the non-anatomical background restricted the clinical validity of the results. Söderman et al ( 19 ) addressed this issue by placing artificial ellipsoid-shaped nodules with known sizes in clinical chest tomosynthesis images. A similar approach was used in a study by Shim et al ( 20 ) , in which model nodules with known sizes were placed in an anthropomorphic chest phantom.…”

Section: Introductionmentioning

confidence: 99%

“…The true sizes of the nodules were, however, not known. Limitations with chest tomosynthesis, in terms of low nodule visibility and decreased nodule size measurement accuracy, was identified by Söderman et al ( 19 ) for nodules at positions in the lung corresponding to locations in low dose areas of the acquired tomosynthesis projection radiographs. This was particularly evident for nodules located behind the heart or the diaphragm.…”

Section: Introductionmentioning

confidence: 99%

Effect of Radiation Dose Level on Accuracy and Precision of Manual Size Measurements in Chest Tomosynthesis Evaluated Using Simulated Pulmonary Nodules

Söderman

Johnsson

Vikgren

et al. 2016

Radiat Prot Dosimetry

Self Cite

View full text Add to dashboard Cite

The aim of the present study was to investigate the dependency of the accuracy and precision of nodule diameter measurements on the radiation dose level in chest tomosynthesis. Artificial ellipsoid-shaped nodules with known dimensions were inserted in clinical chest tomosynthesis images. Noise was added to the images in order to simulate radiation dose levels corresponding to effective doses for a standard-sized patient of 0.06 and 0.04 mSv. These levels were compared with the original dose level, corresponding to an effective dose of 0.12 mSv for a standard-sized patient. Four thoracic radiologists measured the longest diameter of the nodules. The study was restricted to nodules located in high-dose areas of the tomosynthesis projection radiographs. A significant decrease of the measurement accuracy and intraobserver variability was seen for the lowest dose level for a subset of the observers. No significant effect of dose level on the interobserver variability was found. The number of non-measurable small nodules (≤5 mm) was higher for the two lowest dose levels compared with the original dose level. In conclusion, for pulmonary nodules at positions in the lung corresponding to locations in high-dose areas of the projection radiographs, using a radiation dose level resulting in an effective dose of 0.06 mSv to a standard-sized patient may be possible in chest tomosynthesis without affecting the accuracy and precision of nodule diameter measurements to any large extent. However, an increasing number of non-measurable small nodules (≤5 mm) with decreasing radiation dose may raise some concerns regarding an applied general dose reduction for chest tomosynthesis examinations in the clinical praxis.

show abstract

Evaluation of Accuracy and Precision of Manual Size Measurements in Chest Tomosynthesis using Simulated Pulmonary Nodules

Abstract: The results suggest a high accuracy and precision for manual measurements of the nodules in chest tomosynthesis images. However, small nodules (<5.0 mm) may be difficult to measure at all because of poor visibility.

Cited by 15 publications

References 26 publications

Detection of Pulmonary Nodule Growth with Chest Tomosynthesis: A Human Observer Study Using Simulated Nodules

Detection of Pulmonary Nodule Growth with Chest Tomosynthesis: A Human Observer Study Using Simulated Nodules

Detection and Characterization of Solid Pulmonary Nodules at Digital Chest Tomosynthesis: Data from a Cohort of the Pilot Swedish Cardiopulmonary Bioimage Study

Effect of Radiation Dose Level on Accuracy and Precision of Manual Size Measurements in Chest Tomosynthesis Evaluated Using Simulated Pulmonary Nodules

Contact Info

Product

Resources

About