Detection of Pulmonary Nodule Growth with Chest Tomosynthesis: A Human Observer Study Using Simulated Nodules

Söderman, Christina; Johnsson, Åse A.; Vikgren, Jenny; Norrlund, Rauni Rossi; Molnár, Dávid; Mirzai, Maral; Svalkvist, Angelica; Månsson, Lars Gunnar; Båth, Magnus

doi:10.1016/j.acra.2018.05.004

Cited by 4 publications

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“…The present study suffers from unknown "true" change in nodule size, issues which can be solved by using simulated nodules, such as the one from S€ oderman et al (19), which showed good performance of DTS in detection of nodule growth. However, other factors such as better definition of artificial nodule border, location according to the imaging plane, and fewer motion artefacts are circumstances that impair the ability to draw any direct conclusions to a clinical setting.…”

Section: Discussionmentioning

confidence: 96%

“…Söderman et al. (19) investigated nodule growth on simulated nodules in DTS, and reported that the modality could be applicable, but nodule size, position, and dose level affected the precision of the measurements. Other studies have shown a small difference in size estimates between CT and DTS (20,21).…”

Section: Introductionmentioning

confidence: 99%

“…The question has been raised whether DTS could be an alternative to CT regarding surveillance of indeterminate nodules with low risk of malignancy (14,18). S€ oderman et al (19) investigated nodule growth on simulated nodules in DTS, and reported that the modality could be applicable, but nodule size, position, and dose level affected the precision of the measurements. Other studies have shown a small difference in size estimates between CT and DTS (20,21).…”

Section: Introductionmentioning

confidence: 99%

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Surveillance of small, solid pulmonary nodules at digital chest tomosynthesis: data from a cohort of the pilot Swedish CArdioPulmonary bioImage Study (SCAPIS)

et al. 2020

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Background Digital tomosynthesis (DTS) might be a low-dose/low-cost alternative to computed tomography (CT). Purpose To investigate DTS relative to CT for surveillance of incidental, solid pulmonary nodules. Material and Methods Recruited from a population study, 106 participants with indeterminate solid pulmonary nodules on CT underwent surveillance with concurrently performed CT and DTS. Nodule size on DTS was assessed by manual diameter measurements and semi-automatic nodule segmentations were independently performed on CT. Measurement agreement was analyzed according to Bland–Altman with 95% limits of agreement (LoA). Detection of nodule volume change > 25% by DTS in comparison to CT was evaluated with receiver operating characteristics (ROC). Results A total of 81 nodules (76%) were assessed as measurable on DTS by two independent observers. Inter- and intra-observer LoA regarding change in average diameter were ± 2 mm. Calculation of relative volume change on DTS resulted in wide inter- and intra-observer LoA in the order of ± 100% and ± 50%. Comparing relative volume change between DTS and CT resulted in LoA of –58% to 67%. The area under the ROC curve regarding the ability of DTS to detect volumetric changes > 25% on CT was 0.58 (95% confidence interval [CI] = 0.40–0.76) and 0.50 (95% CI = 0.35–0.66) for the two observers. Conclusion The results of the present study show that measurement variability limits the agreement between DTS and CT regarding nodule size change for small solid nodules.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surveillance of small, solid pulmonary nodules at digital chest tomosynthesis: data from a cohort of the pilot Swedish CArdioPulmonary bioImage Study (SCAPIS)

et al. 2020

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Digital tomosynthesis and ground glass nodules: Optimization of acquisition protocol. A phantom study

et al. 2021

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Viewdex 3.0—RECENT Development of a Software Application Facilitating Assessment of Image Quality and Observer Performance

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ViewDEX (Viewer for Digital Evaluation of X-ray Images) is an image viewer compatible with Digital Imaging and Communications in Medicine (DICOM) that has been especially designed to facilitate image perception and observer performance studies within medical imaging. The software was first released in 2004 and since then a continuous development has been ongoing. One of the major drawbacks of previous versions of ViewDEX has been that they have lacked functionality enabling the possibility to evaluate multiple images and/or image stacks simultaneously. This functionality is especially requested by researchers working with modalities, where an image acquisition can result in multiple image stacks (e.g. axial, coronal and sagittal reformations in computed tomography). In ViewDEX 3.0 this functionality has been added and it is now possible to perform image evaluations of multiple images and/or image stacks simultaneously, by using multiple monitors and/or multiple image canvases in monitors. Additionally, some of the previously available functionality has been updated and improved. This paper describes the recent developments of ViewDEX 3.0.

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Detection of Pulmonary Nodule Growth with Chest Tomosynthesis: A Human Observer Study Using Simulated Nodules

Abstract: The study indicates that chest tomosynthesis can be used to detect pulmonary nodule growth. Nodule size, dose level, and mismatch in position relative to the image reconstruction plane in the baseline and follow-up examination may affect the precision.

Cited by 4 publications

References 50 publications

Surveillance of small, solid pulmonary nodules at digital chest tomosynthesis: data from a cohort of the pilot Swedish CArdioPulmonary bioImage Study (SCAPIS)

Surveillance of small, solid pulmonary nodules at digital chest tomosynthesis: data from a cohort of the pilot Swedish CArdioPulmonary bioImage Study (SCAPIS)

Digital tomosynthesis and ground glass nodules: Optimization of acquisition protocol. A phantom study

Viewdex 3.0—RECENT Development of a Software Application Facilitating Assessment of Image Quality and Observer Performance

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