Evaluation of a Skeletal Muscle Energy Convertor in a Chronic Animal Model

Reichenbach, Steven H.; Gustafson, KJ; Egrie, GD; Weidman, JR; Dj, Farrar; Hill, JD

doi:10.1097/00002480-199903000-00197

Cited by 2 publications

(3 citation statements)

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“…Progress has been made towards using skeletal muscle as the power source for a mechanical pump [33,34]. The main problems are the overall efficiency of energy conversion, cost, haemocompatibility, connective tissue investment, and the risk of infection associated with multiple implanted devices.…”

Section: Hybrid Devicesmentioning

confidence: 99%

Cardiac assistance from skeletal muscle: a reappraisal☆

Salmons

2009

European Journal of Cardio-Thoracic Surgery

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SummaryCardiac assistance from skeletal muscle offers an attractive surgical solution to the problem of end-stage heart failure, yet it is widely regarded as a failed approach. I argue here that this is an outdated assessment. Systematic progress has been made over the last 25 years in understanding the relevant basic science. In the light of these advances we should be reconsidering the place of skeletal muscle assist in the surgical armamentarium. #

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Section: Hybrid Devicesmentioning

confidence: 99%

Cardiac assistance from skeletal muscle: a reappraisal☆

Salmons

2009

European Journal of Cardio-Thoracic Surgery

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“…However, initial designs presented in the literature support the choice of a cylindrical piston. 3,9,[11][12][13] The design analysis is intended to assist the initial design stages of development. Shape factors, hydraulic connections, or other correlation methods may be used to apply this analysis to other MCAD designs.…”

Section: Mcad Analysismentioning

confidence: 99%

“…12,13 Although these studies directly evaluate individual MCAD performance, determination of linear LDM performance is complicated by the translation of LDM stroke work through each MCAD design. Knowledge of linear LDM capabilities would allow prediction of performance and analysis of individual MCAD designs and design constraints, thereby improving MCAD design while reducing the experiments.…”

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confidence: 99%

Linear Performance Characteristics of Latissimus Dorsi Muscle: Potential for Cardiac Assistance

2003

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Knowledge of the quantitative performance capabilities of skeletal muscle in a linear geometry is necessary to predict the performance and to optimize the design of linearly configured, skeletal muscle powered cardiac assist devices (MCADs). This study determined the performance characteristics of goat latissimus dorsi muscle (LDM) using a linear, ex vivo experimental apparatus. In five goats, the LDM (130.6 +/- 18.8 g) was dissected free of its distal attachments, connected to a series of weights (500 to 2250 g), and maximal tetanic contractions were elicited via thoracodorsal nerve stimulation. Second order polynomial equations were derived to represent each of the following variables versus load: muscle prestretch (range 1.5 to 5.4 cm), contraction duration (220 to 360 milliseconds), contraction shortening distance (13.5 to 10.9 cm), contraction velocity (60 to 31 cm/s), generated stroke power (3 to 7 W), and stroke work (0.7 to 2.4 J). Analysis of the potential stroke volumes obtained with a linearly configured, cylindrically shaped MCAD directly coupled to the circulation indicate that a feasible MCAD operating region exists based on the LDM performance data across a range of device geometries and mean ejection pressures.

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Evaluation of a Skeletal Muscle Energy Convertor in a Chronic Animal Model

Cited by 2 publications

References 0 publications

Cardiac assistance from skeletal muscle: a reappraisal☆

Cardiac assistance from skeletal muscle: a reappraisal☆

Linear Performance Characteristics of Latissimus Dorsi Muscle: Potential for Cardiac Assistance

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