Evaluation of a Quantitative Automated Micro-hemagglutination Assay for Antibodies to Treponema pallidum

Reactivity of microhemagglutination, fluorescent treponemal antibody absorption, Venereal Disease Research Laboratory, and rapid plasma reagin tests in primary syphilis

“…Ns : .A.. NR WR 1:1 1:2 1:4 1: (3,7,8,13,14,16), whereas others reported a higher sensitivity (1, 15). Luger and Spendlingwimmer (9) reported that MHA-TP test reactivity was greater than the FTA-ABS test reactivity in 21 cases of primary syphilis.…”

Treponema pallidum haemagglutination test for syphilis. Evaluation of a modified micro-method.

“…The T. pallidum Haemagglutination Assay (TPHIA) was originally described as a macro-method, reagents for which are available commercially. An automated quantitative micro-haemagglutination assay, the AMHA-Tp test, was developed and evaluated by Cox, Logan, and Norins (1969) and Logan and Cox (1970). Tringali (1970), Cox, Logan, and Stout (1971), Uete, Fukazawa, Ogi, Takeuchi (1971), Le Clair (1971), and Gamer, Backhouse, Daskalopoulos, and Walsh (1972) have also reported on the clinical usefulness of the TPHA test.…”

Treponemal haemagglutination test.

“…The THA test was the most sensitive test in the remaining groups, and in all groups of treated patients. The high sensitivity of the THA test in treated as compared with untreated early infections is remarkable, although foreshadowed in the preliminary surveys, and found by other workers when untreated and treated patients are classified separately, as in the reports of Logan and Cox (1970) and Cox, Logan, and Stout (1971), who used the technique of Tomizawa and Kasamatsu (TPHA test). Tringali (1970) found the TPHA test slightly less sensitive than the FTA-ABS test but more sensitive than the Kolmer 1/5 vol.…”