Evaluation of a polyvinyl alcohol‐alginate based hydrogel for precise 3D bioprinting

Yu, Fei; Han, Xiao; Zhang, Kaijia; Dai, Bingyang; Shen, Sheng; Gao, Xiang; Teng, Huajian; Wang, Xingsong; Li, Lan; Ju, Huangxian; Wang, Wei; Zhang, Junfeng; Jiang, Qing

doi:10.1002/jbm.a.36483

Cited by 37 publications

(39 citation statements)

References 47 publications

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“…Secondly, different types of cellulose have been used in combination with alginate: cellulose nanocrystals (CNC) (Habib et al, 2018 ; Wu Y. et al, 2018 ), methylcellulose (Li et al, 2017 ; Schütz et al, 2017 ; Ahlfeld et al, 2018 ; Gonzalez-Fernandez et al, 2019 ), and nanofibrillated cellulose (NFC) (Markstedt et al, 2015 ; Apelgren et al, 2017 ). Gelatin and cellulose are followed by GelMA (Liu et al, 2018 ; Zhang X. et al, 2018 ; Kosik-Kozioł et al, 2019 ; Krishnamoorthy et al, 2019 ), PEG-derived (Maiullari et al, 2018 ; Yu et al, 2018 ), agarose (Blaeser et al, 2013 ; López-Marcial et al, 2018 ), hyaluronic acid (Ji et al, 2019 ), and collagen (Campbell et al, 2015 ) to produce hydrogels of two materials. The rest of studies uses three and four-materials hydrogels with 7 and 3 papers, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Specifically, PEGDA presents high hydrophilicity, a bioinert structure, and lack of toxic or immunogenic responses (Zalipsky and Harris, 1997 ). PEGDA is used alone (Schmieg et al, 2018 ) and combined with alginate (Yu et al, 2018 ) and gelatin (Aied et al, 2018 ). It also appears with alginate/GelMA (Kang et al, 2017 ) and with alginate/GelMA/cellulose (García-Lizarribar et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

“…Finally, other cells are used to a lesser extent: MG-63 (5) (Blaeser et al, 2013 ; Duarte Campos et al, 2013 ; Kim et al, 2016 ; McBeth et al, 2017 ; Chen et al, 2018 ), MC3T3 (4) (Peak et al, 2018 ; Wu D. et al, 2018 ; Yu et al, 2018 ; Noh et al, 2019 ), NHDF (3) (Ding et al, 2017 , 2018 ; Choi et al, 2018 ), 3T3 (3) (Wu Y. et al, 2018 ; Xu X. et al, 2018 ; Zheng et al, 2018 ), ATDC5 (3) (Izadifar et al, 2016 ; Hafeez et al, 2018 ; Kim et al, 2019 ), NSCs (2) (Lin et al, 2016 ; Kiyotake et al, 2019 ), Human Fibroblast (2) (Béduer et al, 2018 ; Zhang J. et al, 2018 ), PC12 (2) (Chen et al, 2019 ; Haring et al, 2019 ), HepG2 (2) (Bertassoni et al, 2014 ; Billiet et al, 2014 ), and iPSCs (2) (Nguyen et al, 2017 ; Maiullari et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

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Hydrogels for Bioprinting: A Systematic Review of Hydrogels Synthesis, Bioprinting Parameters, and Bioprinted Structures Behavior

Sánchez¹,

Gómez-Blanco²,

Nieto

et al. 2020

Front. Bioeng. Biotechnol.

106

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Nowadays, bioprinting is rapidly evolving and hydrogels are a key component for its success. In this sense, synthesis of hydrogels, as well as bioprinting process, and cross-linking of bioinks represent different challenges for the scientific community. A set of unified criteria and a common framework are missing, so multidisciplinary research teams might not efficiently share the advances and limitations of bioprinting. Although multiple combinations of materials and proportions have been used for several applications, it is still unclear the relationship between good printability of hydrogels and better medical/clinical behavior of bioprinted structures. For this reason, a PRISMA methodology was conducted in this review. Thus, 1,774 papers were retrieved from PUBMED, WOS, and SCOPUS databases. After selection, 118 papers were analyzed to extract information about materials, hydrogel synthesis, bioprinting process, and tests performed on bioprinted structures. The aim of this systematic review is to analyze materials used and their influence on the bioprinting parameters that ultimately generate tridimensional structures. Furthermore, a comparison of mechanical and cellular behavior of those bioprinted structures is presented. Finally, some conclusions and recommendations are exposed to improve reproducibility and facilitate a fair comparison of results.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogels for Bioprinting: A Systematic Review of Hydrogels Synthesis, Bioprinting Parameters, and Bioprinted Structures Behavior

Sánchez¹,

Gómez-Blanco²,

Nieto

et al. 2020

Front. Bioeng. Biotechnol.

106

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show abstract

“…Asam metaborat merupakan senyawa berwarna putih berbentuk kristal kubik (99) padat dan akan larut di dalam air. (100) Optibor Sifat Fisika (29) Titik Lebur (22) Rumus Kimia (3) Titik Didih (17) Densitas (2) Massa Molar (30) Kelarutan dalam air (16) Sifat Kimia (5) Antiseptik (25) Pelumasan (23) Insektisida (24) piroteknik (20) Pengawet kayu (7) Tenaga Nuklir (6) Penyangga pH (21) Sejarah (15) Kelimpahan (13) B(OH) 3…”

Section: Analisis Gapunclassified

Boric Acid (H3(BO3): Recognize The Molecular Interactions in Solutions

Dwynda¹,

Zainul²

2018

Preprint

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Asam borat biasa dikenal dengan asam boraks merupakan suatu monobasa dari asam Lewis boron lemah yang dapat digunakan sebagai antiseptik, insektisida, penyangga pH, atau penyerap neutron. Asam borat larut dalam air mendidih. Ketika senyawa ini dipanaskan pada suhu melebihi 170OC senyawa ini akan terdehidrasi kemudian membentuk HBO2 atau asam metaborat . Senyawa dengan rumus kimia H3BO3 ini terdapat dalam bentuk serbuk putih yang larut dalam air dan kristal yang tidak berwarna. Penilitian ini bertujuan untuk mengetahui struktur, karakteristik, bentuk molekul dan jenis ikatan dari asam borat. Untuk metode literasi jurnal digunakan aplikasi EndNote yang dijelaskan melalui fishbone state of art. Sedangkan metode yang digunakan untuk melihat hasil optimasi, energi serta gambar dari molekul digunakan metode komputasi dengan software ChemOffice 15.0. Berdasarkan metode ini diperoleh energi kinetik rotasi senyawa 0.3165, dipole/dipole 1.2329 dan energi total 5.1769 kcal/mol. Untuk konduktivitas, kecepatan hanyut, gerakan ion, dilakukan dengan menggunakan metode perhitungan dengan rumusan hasilnya dan beberapa soal yang dibuatkan grafiknya. Secara termodinamika, asam borat pada keadaan standar dan tekanan 1 atm memiliki ∆HoR -5351 kJ / kmol, ∆G°f -122.462 kJ / kmol dengan konstanta kecepatan reaksi k= 8,8727 L/kmol.s. dan Cp pada suhu 100oC sebesar 35,93 J/kgK serta Ho -16.636 J/mol. Proses pembuatan asam borat berlangsung secara spontan dapat dilihat melalui ∆G°f yang bernilai negatif dan terjadi reaksi eksoterm dapat dilihat berdasarkan perolehan ∆HoR yang negatif.

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“…Compared to gels crosslinked by physical interactions, covalent bond-crosslinked alginate gels possess high structural stability and are more suitable for constructing gel structures [5,6,7,8,9]. However, the photo-induced construction of alginate-based gels with mechanical strength-tuning ability, which is very useful in the tissue engineering, is still challenging, requiring photo-responsiveness of both the crosslinking process and the network structure [6,10,11,12]. For example, to prepare the injectable and photo-crosslinking alginate gel, two types of functional groups need to be modified onto the alginate molecules: the aldehyde groups and the methylene groups.…”

Section: Introductionmentioning

confidence: 99%

Reversible Mechanical Regulation and Splicing Ability of Alginate-Based Gel Based on Photo-Responsiveness of Molecular-Level Conformation

Wan

et al. 2019

Materials

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In this study, benefiting from the sensitive molecular conformation transversion in azobenzene, a new strategy for fabricating alginate gels with the abilities of splicing and photo-responsive mechanical adjustment is reported. Firstly, a 4,4’-azobis(benzoylhydrazide) (Azo-hydrazide) linker was used to crosslink alginate physically via the electrostatic interaction between hydrazide groups and carboxyl groups. It was then shaped and transferred in situ to a chemically crosslinked gel via 450 nm light irradiation. Under the irradiation, the molecular conformation change of azobenzene in the linker was able to form covalent bonds at the crosslinking points of the gels. Furthermore, the reversible conformation transformation of azobenzene was able to induce the increase and decrease of the storage modulus under irradiation with 365 nm light and 450 nm light, respectively, while also providing gel-like mechanical properties, depending upon the irradiation time and given wavelength. Meanwhile, the results also indicated that active groups could contribute to the splicing ability of the gel and construct a hollow cavity structure. It is believed that this work could provide a versatile strategy for preparing photo-responsive gels with reversibly tunable mechanical properties.

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Evaluation of a polyvinyl alcohol‐alginate based hydrogel for precise 3D bioprinting

Cited by 37 publications

References 47 publications

Hydrogels for Bioprinting: A Systematic Review of Hydrogels Synthesis, Bioprinting Parameters, and Bioprinted Structures Behavior

Hydrogels for Bioprinting: A Systematic Review of Hydrogels Synthesis, Bioprinting Parameters, and Bioprinted Structures Behavior

Boric Acid (H3(BO3): Recognize The Molecular Interactions in Solutions

Reversible Mechanical Regulation and Splicing Ability of Alginate-Based Gel Based on Photo-Responsiveness of Molecular-Level Conformation

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