Evaluation of a polymer coating containing triclosan as the antimicrobial layer for packaging materials

Chung, Donghwan; Papadakis, Spyros; Yam, Kit L.

doi:10.1046/j.1365-2621.2003.00657.x

Cited by 102 publications

(58 citation statements)

References 14 publications

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“…6 log-reduction/0.5 h) [43]; TiO 2 supported on EVOH (6.3 log-reduction/0.5 h) [7a] or TiO 2 -Ni contains (2 log-reduction for extended period of times) [44]. Other biocides based on simple chemicals as trichlorosan on styrene-acetate copolymers (initial rate enhancement below 2 with respect to the polymer alone) [45]; organometallic complexes leading to oxygen radical formation (3.5 log-reduction/4 h) [46]; or UV-treated Nylon (1.8 log-reduction/6 h) [47] provide further support to our conclusion concerning the good performance of the nanocomposite films here described. The combined analysis of both microorganisms is thus illustrative of the biocidal potential of these films which showed a satisfactory performance if compared with most of the biocidal agents reported up to date.…”

Section: Resultsmentioning

confidence: 99%

Plasmonic Nanoparticle/Polymer Nanocomposites with Enhanced Photocatalytic Antimicrobial Properties

et al. 2009

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We present a simple method of fabricating highly efficient antibacterial nanocomposite films consisting of a commercially available ethylene−vinyl alcohol copolymer (EVOH) and embedded Ag−TiO2 nanoparticles. These systems display potent antimicrobial activity toward Gram-negative, Gram-positive bacteria/cocci (Escherichia coli 1337-H; Pseudomonas putida KT2440, Staphylococcus aureus 1341-H), and yeasts (Pichia jadini) and, moreover, show outstanding resistance to biofilm formation. These nanocomposites differ from known and similar TiO2−EVOH systems by the presence of small quantities (in the 10−2 wt. % level) of silver. Through a plasmonic effect, the presence of the noble metal significantly enhances the antimicrobial power of TiO2−EVOH systems upon ultraviolet (UV) light and opens the fruitful use of visible-light excitation sources. A joint UV−visible and photoluminescence optical characterization of the films allows an understanding of the behavior upon both UV and visible light excitations and provides evidence that the biocidal action comes from the inorganic−organic interface and takes place on the whole nanocomposite surface. These properties indicate that the films are potentially useful as antimicrobial materials in a wide variety of packaging, biomedical, and general use applications.

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Section: Resultsmentioning

confidence: 99%

Plasmonic Nanoparticle/Polymer Nanocomposites with Enhanced Photocatalytic Antimicrobial Properties

et al. 2009

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“…This may be expected since these three test-results were performed in different environments; i.e., the inhibition zone carried out in the soft agar, the %reduction rate performed in peptone solution, and the triclosan releasing result obtained via ethanol solution. Work by Chung et al 15 found that the efficiency for killing bacteria was dependent on the diffusion ability in (Fig. 1) and PCA method (Fig.…”

Section: Effect Of Triclosan Content On Inhibition Zonementioning

confidence: 96%

“…The polymers with greater glass-transition temperatures tended to show lower antimicrobial performances. Chung et al 15 suggested that the effect of triclosan in a styrene-acrylate cothermoplastic on diffusion performance using water, ethanol and n-hexane as diffusion media. It was found that the efficiency for killing bacteria was dependent on the diffusion ability in the media, and diffusion in the ethanol exhibited the highest antimicrobial efficiency.…”

Section: Introductionmentioning

confidence: 99%

Effect of chemical structure of thermoplastics on antibacterial activity and physical diffusion of triclosan doped in vinyl thermoplastics and their composites with CaCO₃

Silapasorn

Sombatsompop

Kositchaiyong

et al. 2011

J of Applied Polymer Sci

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Triclosan was used as antibacterial agent in various vinyl thermoplastics and calcium carbonate (CaCO 3 )/thermoplastic composites and the antibacterial performances were studied through Halo and Plate-CountAgar (PCA) test methods. The thermoplastics used were polyethylene (LDPE, MDPE, HDPE), polypropylene (PP), polystyrene (PS) and poly(vinyl chloride) (PVC). Escherichia coli (E.coli, ATCC 25922) and Stapphylococcus aureus (S.aureus, ATCC 25923) were used as the testing bacteria. The color index results suggested that introducing triclosan did not change the color of all thermoplastics used. The antibacterial results showed that the inhibition zone increased with increasing triclosan for nonpolar thermoplastics like LDPE, MDPE, HDPE, PP, and PS films whereas the opposite effect was observed for polar PVC film. The antibacterial efficacies of the triclosan decreased in the order of LDPE > MDPE > HDPE > PP > PS > PVC and this was confirmed by the triclosan releasing and FT-IR results. The differences in the antibacterial performances of the studied thermoplastics with triclosan were associated with their rigidities, abilities to crystallize, and free volume or molecular density. The sensitivities of E.coli and S.aureus bacteria to the triclosan were found to be dependent on the testing methods used for the antibacterial performance evaluations. The addition of CaCO 3 worsened the antibacterial performances in the triclosan filled HDPE and PS blends, but had a benefit for improved bacterial reduction in the triclosan-filled PVC blend.

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“…In order to avoid implant-associated infections, several strategies have been reported with the aim of creating antimicrobial surfaces, such as the development of (i) non-fouling surfaces (surfaces that avoid protein adsorption and cell adhesion) [1,[18][19][20], (ii) surfaces previously colonized with non-pathogenic bacteria [9], (iii) surfaces combined with biocidal substances [21][22][23] and (iv) surfaces combined with antibiotics [24][25][26].…”

Section: Antimicrobial Coatingsmentioning

confidence: 99%

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

et al. 2011

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a b s t r a c tBacterial adhesion to biomaterials remains a major problem in the medical devices field. Antimicrobial peptides (AMPs) are well-known components of the innate immune system that can be applied to overcome biofilm-associated infections. Their relevance has been increasing as a practical alternative to conventional antibiotics, which are declining in effectiveness. The recent interest focused on these peptides can be explained by a group of special features, including a wide spectrum of activity, high efficacy at very low concentrations, target specificity, anti-endotoxin activity, synergistic action with classical antibiotics, and low propensity for developing resistance. Therefore, the development of an antimicrobial coating with such properties would be worthwhile. The immobilization of AMPs onto a biomaterial surface has further advantages as it also helps to circumvent AMPs' potential limitations, such as short half-life and cytotoxicity associated with higher concentrations of soluble peptides. The studies discussed in the current review report on the impact of covalent immobilization of AMPs onto surfaces through different chemical coupling strategies, length of spacers, and peptide orientation and concentration. The overall results suggest that immobilized AMPs may be effective in the prevention of biofilm formation by reduction of microorganism survival post-contact with the coated biomaterial. Minimal cytotoxicity and longterm stability profiles were obtained by optimizing immobilization parameters, indicating a promising potential for the use of immobilized AMPs in clinical applications. On the other hand, the effects of tethering on mechanisms of action of AMPs have not yet been fully elucidated. Therefore, further studies are recommended to explore the real potential of immobilized AMPs in health applications as antimicrobial coatings of medical devices.

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Evaluation of a polymer coating containing triclosan as the antimicrobial layer for packaging materials

Cited by 102 publications

References 14 publications

Plasmonic Nanoparticle/Polymer Nanocomposites with Enhanced Photocatalytic Antimicrobial Properties

Plasmonic Nanoparticle/Polymer Nanocomposites with Enhanced Photocatalytic Antimicrobial Properties

Effect of chemical structure of thermoplastics on antibacterial activity and physical diffusion of triclosan doped in vinyl thermoplastics and their composites with CaCO₃

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

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Evaluation of a polymer coating containing triclosan as the antimicrobial layer for packaging materials

Cited by 102 publications

References 14 publications

Plasmonic Nanoparticle/Polymer Nanocomposites with Enhanced Photocatalytic Antimicrobial Properties

Plasmonic Nanoparticle/Polymer Nanocomposites with Enhanced Photocatalytic Antimicrobial Properties

Effect of chemical structure of thermoplastics on antibacterial activity and physical diffusion of triclosan doped in vinyl thermoplastics and their composites with CaCO3

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

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Product

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Effect of chemical structure of thermoplastics on antibacterial activity and physical diffusion of triclosan doped in vinyl thermoplastics and their composites with CaCO₃