2003
DOI: 10.1046/j.0041-1132.2003.00587.x
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Evaluation of a new whole‐blood filter that allows preparation of platelet concentrates by platelet‐rich plasma methods

Abstract: A 4- and 3-log WBC reduction was observed in RBC and PC units that were produced by the PRP method, with a mean residual WBC content of 0.24 +/- 0.38 x 106 and 0.02 +/- 0.03 x 106 per unit, respectively. The procedure, performed under relatively simple logistics, results in good-quality, standard components that may reduce costs and ease the process of WBC reduction in transfusion services.

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Cited by 12 publications
(11 citation statements)
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“…The use of some LRFs as research resources has been previously described [5, 6], but not the use of the common Terumo LR Express (TLRE) filter that according to the manufacturer (A. Wegehaupt, personal communication, July 1, 2015) has unique physical properties [7]. Here we describe a procedure for recovering leukocytes from TLRE filters and demonstrate that the recovered cells are well-suited for a variety of research applications.…”
Section: Introductionmentioning
confidence: 93%
“…The use of some LRFs as research resources has been previously described [5, 6], but not the use of the common Terumo LR Express (TLRE) filter that according to the manufacturer (A. Wegehaupt, personal communication, July 1, 2015) has unique physical properties [7]. Here we describe a procedure for recovering leukocytes from TLRE filters and demonstrate that the recovered cells are well-suited for a variety of research applications.…”
Section: Introductionmentioning
confidence: 93%
“…To avoid undesirable elimination of platelets, a platelet-sparing LR filter (Imuflex WB-SP; Terumo Corporation, Tokyo, Japan) was developed. This filter has the capability to create blood products that meet or exceed Food and Drug Administration processing (FDA) regulations and has been validated to preserve platelets while effectively leukoreducing whole blood [5][6][7]. FDA regulations, however, do not require in vivo assessment of coagulation thus the impact of the platelet-sparing LR filter on the coagulation profile and function of the platelets within whole blood products is unclear [8].…”
Section: Introductionmentioning
confidence: 99%
“…It would not only contribute to the reduced incidence of cytokine-mediated transfusion reactions but also create the conditions for reduced activation of thrombocytes in vitro, with improved therapeutic efficacy [11].…”
Section: Introductionmentioning
confidence: 99%