Evaluation of a new polymorph azlocillin sodium by its antibacterial activity

Opalchenova, Ginka; Kalinkova, G.N.

doi:10.1016/s0378-5173(97)00087-2

Cited by 10 publications

(2 citation statements)

References 5 publications

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“…Crystal form affects properties such as drug absorption, rate of dissolution, elimination rate and stability in galenic preparations (Opalchenova and Kalinkova, 1997;Sohn, 2007;Lee and Sonh, 2008).…”

Section: Introductionmentioning

confidence: 99%

Solid state of CG-400549, a novel FabI inhibitor: Characterization, dissolution, transformation

Kim

Sohn

2011

Arch. Pharm. Res.

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The polymorphic and pseudopolymorphic forms of CG-400549, a novel FabI inhibitor with potent in vivo activity were prepared and characterized by differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD) and thermogravimetric analysis (TG). Seven crystal forms of CG-400549, one anhydrate and six solvates, have been isolated by recrystallization and the DSC and PXRD patterns of the seven crystal forms of CG-400549 were different respectively. The dissolution patterns of these seven crystal forms of CG-400549 were studied and they showed significant differences in the dissolution rate. After storage of 1 month at 0% RH (silica gel, 20°C), 52% RH (saturated solution of Na(2)Cr(2)O(7)2H(2)O/20°C) and 95% RH (saturated solution of Na(2)HPO(4)/20°C), all crystal forms were not transformed.

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Section: Introductionmentioning

confidence: 99%

Solid state of CG-400549, a novel FabI inhibitor: Characterization, dissolution, transformation

Kim

Sohn

2011

Arch. Pharm. Res.

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“…It is important in pharmaceutical industry, where polymorphism of a drug can strongly affect its bioavailability and stability [1]. It has been also shown that antibacterial activity of a compound can depend on its crystallinity [2]. Therefore, a rapid development in the prediction, screening and analysis of orally administered drug polymorphs is expected in the future [3].…”

Section: Introductionmentioning

confidence: 99%