Abstract:This study has shown that the 3D color Doppler flow quantification method we used is able to compute stroke volumes accurately at the MV annulus and LVOT in the same cardiac cycle without electrocardiographic gating. This method may be valuable for assessment of cardiac output in clinical studies.
“…Previously reported studies on BHMV testing have been mostly described in the aortic position (8)(9)(10). Several studies also focus on mitral valvular prosthesis testing only (11)(12)(13). The results presented here show that maximum transmitral velocity is significantly lower than the threshold suggested by ASE guidelines, even for total leaflet obstruction in the case of St. Jude prosthesis.…”
Section: Transvalvular Maximum Velocity and Mean Gradientmentioning
Malfunction of bileaflet mechanical heart valves in the mitral position could either be due to patient-prosthesis mismatch (PPM) or leaflet obstruction. The aim of this article is to investigate the validity of current echocardiographic criteria used for diagnosis of mitral prosthesis malfunction, namely maximum velocity, mean transvalvular pressure gradient, effective orifice area, and Doppler velocity index. In vitro testing was performed on a double activation left heart duplicator. Both PPM and leaflet obstruction were investigated on a St. Jude Medical Master. PPM was studied by varying the St. Jude prosthesis size (21, 25, and 29 mm) and stroke volume (70 and 90 mL). Prosthesis leaflet obstruction was studied by partially or totally blocking the movement of one valve leaflet. Mitral flow conditions were altered in terms of E/A ratios (0.5, 1.0, and 1.5) to simulate physiologic panel of diastolic function. Maximum velocity, effective orifice area, and Doppler velocity index are shown to be insufficient to distinguish normal from malfunctioning St. Jude prostheses. Doppler velocity index and effective orifice area were 1.3 ± 0.49 and 1.83 ± 0.43 cm(2) for testing conditions with no malfunction below the 2.2 and 2 cm(2) thresholds (1.19 cm(2) for severe PPM and 1.23 cm(2) for fully blocked leaflet). The mean pressure gradient reached 5 mm Hg thresholds for several conditions of severe PPM only (6.9 mm Hg and mean maximum velocity value: 183.4 cm/s) whereas such value was never attained in the case of leaflet obstruction. In the case of leaflet obstruction, the maximum velocity averaged over the nine pulsed-wave Doppler locations increased by 38% for partial leaflet obstruction and 75% for a fully blocked leaflet when compared with normal conditions. Current echocardiographic criteria might be suboptimal for the detection of bileaflet mechanical heart valve malfunction. Further developments and investigations are required in order to further improve current guidelines.
“…Previously reported studies on BHMV testing have been mostly described in the aortic position (8)(9)(10). Several studies also focus on mitral valvular prosthesis testing only (11)(12)(13). The results presented here show that maximum transmitral velocity is significantly lower than the threshold suggested by ASE guidelines, even for total leaflet obstruction in the case of St. Jude prosthesis.…”
Section: Transvalvular Maximum Velocity and Mean Gradientmentioning
Malfunction of bileaflet mechanical heart valves in the mitral position could either be due to patient-prosthesis mismatch (PPM) or leaflet obstruction. The aim of this article is to investigate the validity of current echocardiographic criteria used for diagnosis of mitral prosthesis malfunction, namely maximum velocity, mean transvalvular pressure gradient, effective orifice area, and Doppler velocity index. In vitro testing was performed on a double activation left heart duplicator. Both PPM and leaflet obstruction were investigated on a St. Jude Medical Master. PPM was studied by varying the St. Jude prosthesis size (21, 25, and 29 mm) and stroke volume (70 and 90 mL). Prosthesis leaflet obstruction was studied by partially or totally blocking the movement of one valve leaflet. Mitral flow conditions were altered in terms of E/A ratios (0.5, 1.0, and 1.5) to simulate physiologic panel of diastolic function. Maximum velocity, effective orifice area, and Doppler velocity index are shown to be insufficient to distinguish normal from malfunctioning St. Jude prostheses. Doppler velocity index and effective orifice area were 1.3 ± 0.49 and 1.83 ± 0.43 cm(2) for testing conditions with no malfunction below the 2.2 and 2 cm(2) thresholds (1.19 cm(2) for severe PPM and 1.23 cm(2) for fully blocked leaflet). The mean pressure gradient reached 5 mm Hg thresholds for several conditions of severe PPM only (6.9 mm Hg and mean maximum velocity value: 183.4 cm/s) whereas such value was never attained in the case of leaflet obstruction. In the case of leaflet obstruction, the maximum velocity averaged over the nine pulsed-wave Doppler locations increased by 38% for partial leaflet obstruction and 75% for a fully blocked leaflet when compared with normal conditions. Current echocardiographic criteria might be suboptimal for the detection of bileaflet mechanical heart valve malfunction. Further developments and investigations are required in order to further improve current guidelines.
“…Siemens’ hemispheric 3D flow analysis package (Siemens Medical Solutions USA Inc.) was used to analyze RT3D‐CDE data. Hemispheric 3D flow sampling planes used for the measurement of flow volumes (in milliliters) have been described and validated . Using two perpendicular long‐axis views and one short‐axis view at end‐systole for guidance, the sample plate size and location was manually adjusted to avoid aliasing and encompass the cross‐sectional area of the VSD(s) color Doppler flow signal.…”
Section: Methodsmentioning
confidence: 99%
“…Hemispheric 3D flow sampling planes used for the measurement of flow volumes (in milliliters) have been described and validated. 23,28,[30][31][32]35 Using two perpendicular long-axis views and one short-axis view at end-systole for guidance, the sample plate size and location was manually adjusted where dA is the unit sampling area on the sampling plane, fr is the frame rate, vs is the Doppler velocity scale, N a is the number of nonzero samples on the sample plane, (i) is the 3D position of the sampling area, F t is the color flow image, and t is the time instance. 36 Software-generated shunt volumes were acquired for each model VSD and compared to known stroke volume values set by the pulsatile pump apparatus to verify RT3D-CDE shunt volume quantification accuracy.…”
Section: Siemens' Hemispheric 3d Flow Analysis Package (Siemens Medicalmentioning
confidence: 99%
“…Instantaneous acquisition of color Doppler volume without gating is made possible by the use of real time 3D‐CDE (RT3D‐CDE), which uses a matrix phased array transducer acquiring flow information more directly and rapidly than 3D‐CDE . Using nongated echocardiography, artifacts caused by gating do not occur .…”
Section: Introductionmentioning
confidence: 99%
“…8,[21][22][23][24][25][26][27] Instantaneous acquisition of color Doppler volume without gating is made possible by the use of real time 3D-CDE (RT3D-CDE), which uses a matrix phased array transducer acquiring flow information more directly and rapidly than 3D-CDE. 28 Using nongated echocardiography, artifacts caused by gating do not occur. 29 Real time 3D color Doppler echocardiography (RT3D-CDE) is able to continuously and simultaneously acquire full volume, B-mode, and color Doppler images with up to a 90 × 90° volume sector.…”
Background
Quantification of defect size and shunt flow is an important aspect of ventricular septal defect (VSD) evaluation. This study compared three‐dimensional echocardiography (3DE) with the current clinical standard two‐dimensional echocardiography (2DE) for quantifying defect area and tested the feasibility of real time 3D color Doppler echocardiography (RT3D‐CDE) for quantifying shunt volume of irregular shaped and multiple VSDs.
Methods
Latex balloons were sutured into the ventricles of 32 freshly harvested porcine hearts and were connected with tubing placed in septal perforations. Tubing was varied in area (0.13–5.22 cm²), number (1–3), and shape (circle, oval, crescent, triangle). A pulsatile pump was used to pump “blood” through the VSD (LV to RV) at stroke volumes of 30–70 mL with a stroke rate of 60 bpm. Two‐dimensional echocardiography (2DE), 3DE, and RT3D‐CDE images were acquired from the right side of the phantom.
Results
For circular VSDs, both 2DE and 3DE area measurements were consistent with the actual areas (R² = 0.98 vs 0.99). For noncircular/multiple VSDs, 3DE correlated with the actual area more closely than 2DE (R² = 0.99 vs 0.44). Shunt volumes obtained using RT3D‐CDE positively correlated with pumped stroke volumes (R² = 0.96).
Conclusions
Three‐dimensional echocardiography (3DE) is a feasible method for determining VSD area and is more accurate than 2DE for evaluating the area of multiple or noncircular VSDs. Real‐time 3D color Doppler echocardiography (RT3D‐CDE) is a feasible method for quantifying the shunt volume of multiple or noncircular VSDs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.