Evaluation of a Myopic Normative Database for Analysis of Retinal Nerve Fiber Layer Thickness

Biswas, Sayantan; Chen, Lin; Leung, Christopher Kai-Shun

doi:10.1001/jamaophthalmol.2016.2343

Cited by 62 publications

(36 citation statements)

References 22 publications

(20 reference statements)

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“…Cirrus HD-OCT provides a built-in normative database comprised of 271 healthy individuals with a mean spherical equivalence of À0.82 6 1.96 D. 34 The low proportion of myopic eyes in the internal normative database is likely to be related to the high rates of false-positive errors in myopic eyes. 10,35 In the present study, the rate of false-positive errors (P < 1%) for RNFL thickness was significantly higher in high myopia (62.8%) than mild-to- Statistically significant values are shown in bold. * NA, Correction is undefined for curves below the diagonal: uncorrected pAUC < the value of the nondiscriminant AUC (with an AUC of 0.5 or 50) in the region.…”

Section: Discussionmentioning

confidence: 52%

“…[5][6][7] Nonetheless, myopia is notorious for causing false-positive errors on the OCT-measured RNFL thickness map. 4,[8][9][10] This phenomenon can be attributed to (1) vessel temporalization during myopic axial elongation, which can affect the peak distribution of RNFL thickness, [11][12][13] (2) inherent measurement errors in eyes with myopic refraction or longer axial lengths (AXL), due to the OCT magnification effect [14][15][16] , and (3) OCT scan-circle misalignment on the optic disc. 17,18 Kim et al 19 warned that greater AXL and smaller disc area is significantly associated with false-positive red signs in cases of SD-OCT-measured RNFL thickness.…”

mentioning

confidence: 99%

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Diagnostic Accuracy of Three-Dimensional Neuroretinal Rim Thickness for Differentiation of Myopic Glaucoma From Myopia

Kim

Park

2018

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 52%

mentioning

confidence: 99%

Diagnostic Accuracy of Three-Dimensional Neuroretinal Rim Thickness for Differentiation of Myopic Glaucoma From Myopia

Kim

Park

2018

Invest. Ophthalmol. Vis. Sci.

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“…A mathematical solution may approximate true expected RNFL thickness values, but an empirical OCT normative database for eyes with high myopia, as suggested by Biswas et al, 2 would address the problem directly. The use and utility of OCT are high.…”

mentioning

confidence: 99%

Optical Coherence Tomography in High Myopia

Schuman

2016

JAMA Ophthalmol

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“…The superotemporal and inferotemporal RNFL bundles angle decreases with increasing myopia 21 and the application of the OCT normative data would decrease the specificity for detection of RNFL abnormalities in eyes with myopia. 22 Another limitation of the Spectralis OCT is the lack of topographic analysis of the RNFLT. The discriminating power of the circumpapillary RNFLT diagnostic classification is inferior to the analysis of RNFL thickness deviation map (6×6 mm 2 ) for glaucoma detection.…”

Section: Clinical Sciencementioning

confidence: 99%

Diagnostic criteria for detection of retinal nerve fibre layer thickness and neuroretinal rim width abnormalities in glaucoma

Zheng

Leung

2019

Br J Ophthalmol

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Background/aimsAlthough measurements of the Bruch’s membrane opening minimum rim width (BMO-MRW) and retinal nerve fibre layer thickness (RNFLT) with optical coherence tomography (OCT) have been widely adopted in the diagnostic evaluation of glaucoma, there is no consensus on the diagnostic criteria to define BMO-MRW and RNFLT abnormalities. This study investigated the sensitivities and specificities of different diagnostic criteria based on the OCT classification reports for detection of glaucoma.Methods340 eyes of 137 patients with glaucoma and 87 healthy individuals, all with axial length ≤26mm, had global and sectoral BMO-MRW and RNFLT measured with Spectralis OCT (Heidelberg Engineering). Six diagnostic criteria were examined: global measurement below the fifth or the first percentile; ≥1 sector measurement below the fifth or the first percentile; superotemporal and/or inferotemporal measurement below the fifth or the first percentile. The sensitivities and specificities of BMO-MRW/RNFLT assessment for detection of glaucoma (eyes with visual field (VF) defects) were compared.ResultsAmong the six criteria examined, superotemporal and/or inferotemporal measurement below the fifth percentile showed the highest sensitivities and specificities for glaucoma detection. Abnormal superotemporal and/or inferotemporal RNFLT attained a higher sensitivity than abnormal superotemporal and/or inferotemporal BMO-MRW to detect mild glaucoma (mean VF MD: −3.32±1.59 dB) (97.9% and 88.4%, respectively, p=0.006), and glaucoma (mean VF MD: −9.36±8.31 dB) (98.4% and 93.6%, respectively, p=0.006), at the same specificity (96.1%).ConclusionsSuperotemporal and/or inferotemporal RNFLT/MRW below the fifth percentile yield the best diagnostic performance for glaucoma detection with RNFLT attains higher sensitivities than MRW at the same specificity in eyes without high myopia.

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Evaluation of a Myopic Normative Database for Analysis of Retinal Nerve Fiber Layer Thickness

Cited by 62 publications

References 22 publications

Diagnostic Accuracy of Three-Dimensional Neuroretinal Rim Thickness for Differentiation of Myopic Glaucoma From Myopia

Diagnostic Accuracy of Three-Dimensional Neuroretinal Rim Thickness for Differentiation of Myopic Glaucoma From Myopia

Optical Coherence Tomography in High Myopia

Diagnostic criteria for detection of retinal nerve fibre layer thickness and neuroretinal rim width abnormalities in glaucoma

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