Evaluation of a modified lateral flow immunoassay for detection of high-sensitivity cardiac troponin I andmyoglobin

Zhu, Ji‐Min; Zou, Nengli; Mao, Hongju; Wang, Ping; Zhu, Danian; Ji, Huoyan; Cong, Hui; Sun, Changjiang; Wang, Huimin; Zhang, Feng; Qian, Juying; Jin, Qinghui; Zhao, Jianlong

doi:10.1016/j.bios.2012.10.016

Cited by 38 publications

(16 citation statements)

References 14 publications

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“…Since acute myocardial infarction (AMI) remains the leading cause of death in most industrialized nations, it is important to evaluate accurately the patients who show symptoms suggestive of AMI [1,2]. Myoglobin, although not cardiac specific, has been widely suggested as one of the best candidate markers for an early diagnosis of AMI [3].…”

Section: Introductionmentioning

confidence: 99%

Visual detection of myoglobin via G-quadruplex DNAzyme functionalized gold nanoparticles-based colorimetric biosensor

Wang

Yang

et al. 2015

Sensors and Actuators B: Chemical

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Section: Introductionmentioning

confidence: 99%

Visual detection of myoglobin via G-quadruplex DNAzyme functionalized gold nanoparticles-based colorimetric biosensor

Wang

Yang

et al. 2015

Sensors and Actuators B: Chemical

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“…Compared with the single detection, simultaneous detection offers many advantages such as simple, timesaving, sample saving, and no need for checking the suspected parameters [114,115,71]. A combination of colloidal gold nanoparticles and oligonucleotide LFB was described by Yuichi Oku et al [116] for the simultaneous detection of antigens (HBs antigen) and antibodies (Treponema pallidum, TP) in specimens.…”

Section: Simultaneous Detectionmentioning

confidence: 99%

“…Zhu et al [115] detected cardiac troponin I (hs-cTnl) and myoglobin simultaneously to exclude acute myocardial infarction (AMI) via GNPs based LFB. In this study, the specimens of cardiac troponin I (hs-cTnl) and myoglobin were collected from 173 patients with AMI symptoms.…”

Section: Simultaneous Detectionmentioning

confidence: 99%

Recent Advances in Nanoparticles-based Lateral Flow Biosensors

Gao¹,

Xu²,

Zhou³

et al. 2014

Am. J. Biomed. Sci.

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Lateral flow biosensors (LFBs) provide advantages in low cost, simplicity, rapidity, stability and portability, thus making LFBs popular in biomedical, agriculture, food and environmental sciences. This article reviews recent advances of LFBs for bioassays, including the investigation of the improvements achieved by signal-amplification strategies, the application of new nanoparticle labels, novel quantitative system and simultaneous detection. We summarized the outstanding performances of LFBs such as high detection sensitivity, specificity, reproducibility and reliability.

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“…The prevention or treatment of acute myocardial infarction (AMI) for people has become especially urgent, and accurate diagnosis of the patients is essential coequally [1]. It is worth mentioning that myoglobin is the main marker of early acute myocardial infarction as the concentration of myoglobin could indicate myocardial damage [2].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Aptasensor for Myoglobin-Specific Recognition Based on Porphyrin Functionalized Graphene-Conjugated Gold Nanocomposites

Zhang

Liu

Wang

et al. 2016

Sensors

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In this work, a novel electrochemical aptasensor was developed for sensitive and selective detection of myoglobin based on meso-tetra (4-carboxyphenyl) porphyrin-functionalized graphene-conjugated gold nanoparticles (TCPP–Gr/AuNPs). Due to its good electric conductivity, large specific surface area, and excellent mechanical properties, TCPP–Gr/AuNPs can act as an enhanced material for the electrochemical detection of myoglobin. Meanwhile, it provides an effective matrix for immobilizing myoglobin-binding aptamer (MbBA). The electrochemical aptasensor has a sensitive response to myoglobin in a linear range from 2.0 × 10−11 M to 7.7 × 10−7 M with a detection limit of 6.7 × 10−12 M (S/N = 3). Furthermore, the method has the merits of high sensitivity, low price, and high specificity. Our work will supply new horizons for the diagnostic applications of graphene-based materials in biomedicine and biosensors.

show abstract

Evaluation of a modified lateral flow immunoassay for detection of high-sensitivity cardiac troponin I andmyoglobin

Cited by 38 publications

References 14 publications

Visual detection of myoglobin via G-quadruplex DNAzyme functionalized gold nanoparticles-based colorimetric biosensor

Visual detection of myoglobin via G-quadruplex DNAzyme functionalized gold nanoparticles-based colorimetric biosensor

Recent Advances in Nanoparticles-based Lateral Flow Biosensors

Electrochemical Aptasensor for Myoglobin-Specific Recognition Based on Porphyrin Functionalized Graphene-Conjugated Gold Nanocomposites

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