Evaluation of a local anesthetic delivery system for the postoperative analgesic management of canine total ear canal ablation – a randomized, controlled, double-blinded study

Wolfe, Tina M.; Bateman, Shane; Cole, Lynette K.; Smeak, Daniel D.

doi:10.1111/j.1467-2995.2005.00272.x

Cited by 43 publications

(29 citation statements)

References 37 publications

(43 reference statements)

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“…External otitis affects chondrodystrophoid breeds and is typically treated by total ear canal ablation with bulla osteotomy (TECABO), which is a highly invasive and painful surgical procedure [7]. It has been reported that continuous subcutaneous injection of Lido is effective in managing the post-operative pain of TECABO [38]. Furthermore, ovariohysterectomy is a very common surgical procedure in dogs, and Carpenter et al reported that intraperitoneal injection of Lido and bupivacaine reduces postoperative pain [9].…”

Section: Discussionmentioning

confidence: 99%

Effects of Lidocaine Hydrochloride on Canine Granulocytes, Granulocyte CD11b Expression and Reactive Oxygen Species Production

Maeda

Sakonju

Kumakura

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. Lidocaine hydrochloride (Lido) is widely used for analgesia in veterinary medicine; however, in humans, it has been suggested that Lido attenuates granulocyte functions, such as adhesion and reactive oxygen species (ROS) production. Thus, Lido may affect canine granulocyte function; however, there have been no reports on the effects of Lido on canine granulocyte function. Thus, we studied the effects of Lido on canine granulocyte CD11b expression and ROS production. We further studied the effects of Lido on the priming of canine granulocyte CD11b expression and ROS production by recombinant canine granulocyte macrophage colony stimulating factor (rcGM-CSF). Isolated granulocytes were incubated with 3, 30 or 300 g/ml Lido, or with Lido followed by priming with 5 ng/ml rcGM-CSF. CD11b was detected by the immune fluorescent antibody method, and the mean fluorescence intensity (MFI) was assayed by flow cytometry. ROS production was assessed by the peak time (PT) of ROS production and area under the luminol reaction curve (AUC), which represents total ROS production quantity against opsonized zymosan stimuli. Only 300 g/ml Lido (tissue level observed by regional block) significantly attenuated both the MFI of CD11b and its enhancement by rcGM-CSF. Moreover, at this concentration, the AUC and its enhancement by rcGM-CSF were significantly attenuated by Lido; in contrast, Lido did not affect PT. In conclusion, Lido suppressed granulocyte adhesion to the endothelium and antiseptic capability by suppressing CD11b expression and/or ROS production. Particular care should thus be exercised when performing regional anesthesia block using Lido.

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Section: Discussionmentioning

confidence: 99%

Effects of Lidocaine Hydrochloride on Canine Granulocytes, Granulocyte CD11b Expression and Reactive Oxygen Species Production

Maeda

Sakonju

Kumakura

et al. 2010

The Journal of Veterinary Medical Science

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“…Σε αντίθεση με τον σκΰλο, στον οποίο χρησιμοποιούνται και άλλοι τρόποι εφαρ μογής των τοπικών αναισθητικών, όπως για παράδειγ μα η διήθηση των χειλέων του χειρουργικού τραύματος (Sawas et al 2007), η συνεχής τοπική χορήγηση κ.ά. (Wolfe et al 2006), στη γάτα αυτοί οι τρόποι είτε δεν έχουν μελετηθεί είτε έχουν βρεθεί αναποτελεσματικοί (Tobias et al 2006). Συμπερασματικά, η προσπάθεια να αντιμετωπιστεί αποτελεσματικά ο πόνος στη γάτα πρέπει να στηρίζε ται σε τρεις αρχές.…”

Section: τοποπεριοχικές μέθοδοι αναλγησίαςunclassified

Pain management in cat

Kazakos

Savvas

Raptopoulos

2017

J Hellenic Vet Med Soc

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Although cats are very popular pets, pain in this species is often underestimated. The reasons for this may include difficulties in pain recognition, unfamiliarity with the use of opioids or non-steroidal analgesic drugs, and with the application of local analgesic techniques. Proper pain management should always be undertaken mainly for medical and humane purposes. Pre-emptive and multimodal analgesia can aid significanly in postoperative pain alleviation. Nowadays, the veterinarian's armamentarium is equipped with a variety of agents in order to alleviate pain in cats. Non-steroidal anti-inflammatory drugs are often as effective as opioids. The latter are now used successfully for pain management in cats. Both classes provide safe analgesia, taking into account the differences in metabolism between cats and other species. Adjunctive analgesic therapy may be provided with the use of ketamine or a2-adrenergic receptor agonists. Loco-regional analgesic techniques can be used to effectively manage pain in a variety of clinical settings.

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“…30 Another method of analgesic administration has been described with the use a local anesthetic delivery system that allows continuous delivery of local anesthetics via a fenestrated catheter ( Figure 13.4). 31,32 An elastomeric bulb or syringe pump device is filled with drug to deliver a constant volume directly to the surgical site. Results of these studies suggest that there is little or no benefit in using local anesthetic blocks in dogs that underwent TECA.…”

Section: Management Of Anesthesiamentioning

confidence: 99%

Skin and Musculoskeletal Diseases

Steagall

2014

Canine and Feline Anesthesia and Co‐Existing Disease

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Evaluation of a local anesthetic delivery system for the postoperative analgesic management of canine total ear canal ablation – a randomized, controlled, double-blinded study

Cited by 43 publications

References 37 publications

Effects of Lidocaine Hydrochloride on Canine Granulocytes, Granulocyte CD11b Expression and Reactive Oxygen Species Production

Effects of Lidocaine Hydrochloride on Canine Granulocytes, Granulocyte CD11b Expression and Reactive Oxygen Species Production

Pain management in cat

Skin and Musculoskeletal Diseases

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