Evaluation of a Large Pixellated Cadmium Zinc Telluride Detector for Small Animal Radionuclide Imaging

Izaguirre, Enrique; Sun, Mengtao; Vandehei, T.; Després, Philippe; Huang, Yuanyuan; Funk, Tobias; Li, Junqiang; Parnham, K.; Pratt, B.; Hasegawa, B.H.

doi:10.1109/nssmic.2006.353823

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…The simulated detector energy resolutions and energy windows are shown in table 1. The energy resolutions for different isotopes were based on the published information [2,[23][24][25] and our previous experimental studies. In addition, the quantitative error as a function of energy window width was also investigated.…”

Section: Gate Simulationsmentioning

confidence: 99%

Evaluation of quantitative accuracy in CZT-based pre-clinical SPECT for various isotopes

Park

Kim

et al. 2015

J. Inst.

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In vivo pre-clinical single-photon emission computed tomography (SPECT) is a valuable tool for functional small animal imaging, but several physical factors, such as scatter radiation, limit the quantitative accuracy of conventional scintillation crystal-based SPECT. Semiconductor detectors such as CZT overcome these deficiencies through superior energy resolution. To our knowledge, little scientific information exists regarding the accuracy of quantitative analysis in CZT-based pre-clinical SPECT systems for different isotopes. The aim of this study was to assess the quantitative accuracy of CZT-based pre-clinical SPECT for four isotopes: 201 Tl, 99m Tc, 123 I, and 111 In. The quantitative accuracy of the CZT-based Triumph X-SPECT (Gamma-Medica Ideas, Northridge, CA, U.S.A.) was compared with that of a conventional SPECT using GATE simulation. Quantitative errors due to the attenuation and scatter effects were evaluated for all four isotopes with energy windows of 5%, 10%, and 20%. A spherical source containing the isotope was placed at the center of the air-or-water-filled mouse-sized cylinder phantom. The CZT-based pre-clinical SPECT was more accurate than the conventional SPECT. For example, in the conventional SPECT with an energy window of 10%, scatter effects degraded quantitative accuracy by up to 11.52%, 5.10%, 2.88%, and 1.84% for 201 Tl, 99m Tc, 123 I, and 111 In, respectively. However, with the CZT-based pre-clinical SPECT, the degradations were only 9.67%, 5.45%, 2.36%, and 1.24% for 201 Tl, 99m Tc, 123 I, and 111 In, respectively. As the energy window was increased, the quantitative errors increased in both SPECT systems. Additionally, the isotopes with lower energy of photon emissions had greater quantitative error. Our results demonstrated that the CZT-based pre-clinical SPECT had lower overall quantitative errors due to reduced scatter and high detection efficiency. Furthermore, the results of this systematic assessment quantifying the accuracy of these SPECT for various isotopes will provide valuable reference information for the design of CZT-based preclinical SPECT system imaging protocols.

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Section: Gate Simulationsmentioning

confidence: 99%

Evaluation of quantitative accuracy in CZT-based pre-clinical SPECT for various isotopes

Park

Kim

et al. 2015

J. Inst.

View full text Add to dashboard Cite

show abstract

“…To cope with this resolution issue [3], small animal SPECT systems with pinhole collimators have been proposed [4][5][6][7] and lack of the intrinsic spatial resolution of the scintillation detector was compensated for with the geometrical magnification effect of the pinhole collimator. Another strategy to improve the spatial resolution of the small animal SPECT system is utilization of pixelated detectors such as discrete NaI(Tl) or CsI(Tl) crystals [8][9][10][11][12][13] or cadmium telluride (CdTe) or cadmium zinc telluride (CdZnTe) semiconductor detectors [14][15][16][17][18][19][20][21][22][23], which are used with a parallel-hole collimator or pinhole collimator. The pixelated nature of these detectors is expected to greatly improve the spatial resolution when we use very small pixels in a detector at the sacrifice of the detection efficiency.…”

Section: Introductionmentioning

confidence: 99%