Development of an ultra-high resolution SPECT system with a CdTe semiconductor detector

Ogawa, Kōichi; Ohmura, Naoka; Iida, Hajimu; Nakamura, Kayoko; Nakahara, Tsutomu; Kubo, Atsushi

doi:10.1007/s12149-009-0293-x

Cited by 37 publications

(33 citation statements)

References 30 publications

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“…As of March 2011, no initiative has been taken up yet by NEMA for small-animal SPECT guidelines. Most of the scientific literature on image quality in small-animal SPECT is based on qualitative demonstrations of the effective spatial resolution using Derenzo-like phantoms with hot and cold rods (2,(4)(5)(6)(7)(8)(9). An anatomic phantom to mimic rat brain structures has been described by Beekman et al (10).…”

mentioning

confidence: 99%

Using the NEMA NU 4 PET Image Quality Phantom in Multipinhole Small-Animal SPECT

Harteveld¹,

Meeuwis²,

Disselhorst³

et al. 2011

J Nucl Med

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Several commercial small-animal SPECT scanners using multipinhole collimation are presently available. However, generally accepted standards to characterize the performance of these scanners do not exist. Whereas for small-animal PET, the National Electrical Manufacturers Association (NEMA) NU 4 standards have been defined in 2008, such standards are still lacking for small-animal SPECT. In this study, the image quality parameters associated with the NEMA NU 4 image quality phantom were determined for a small-animal multipinhole SPECT scanner. Methods: Multiple whole-body scans of the NEMA NU 4 image quality phantom of 1-h duration were performed in a U-SPECT-II scanner using 99m Tc with activities ranging between 8.4 and 78.2 MBq. The collimator contained 75 pinholes of 1.0-mm diameter and had a bore diameter of 98 mm. Image quality parameters were determined as a function of average phantom activity, number of iterations, postreconstruction spatial filter, and scatter correction. In addition, a mouse was injected with 99m Tc-hydroxymethylene diphosphonate and was euthanized 6.5 h after injection. Multiple whole-body scans of this mouse of 1-h duration were acquired for activities ranging between 3.29 and 52.7 MBq. Results: An increase in the number of iterations was accompanied by an increase in the recovery coefficients for the small rods (RC rod ), an increase in the noise in the uniform phantom region, and a decrease in spillover ratios for the cold-air-and water-filled scatter compartments (SOR air and SOR wat ). Application of spatial filtering reduced image noise but lowered RC rod . Filtering did not influence SOR air and SOR wat . Scatter correction reduced SOR air and SOR wat . The effect of total phantom activity was primarily seen in a reduction of image noise with increasing activity. RC rod , SOR air , and SOR wat were more or less constant as a function of phantom activity. The relation between acquisition and reconstruction settings and image quality was confirmed in the 99m Tc-hydroxymethylene diphosphonate mouse scans. Conclusion: Although developed for small-animal PET, the NEMA NU 4 image quality phantom was found to be useful for small-animal SPECT as well, allowing for objective determination of image quality parameters and showing the tradeoffs between several of these parameters on variation of acquisition and reconstruction settings.

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mentioning

confidence: 99%

Using the NEMA NU 4 PET Image Quality Phantom in Multipinhole Small-Animal SPECT

Harteveld¹,

Meeuwis²,

Disselhorst³

et al. 2011

J Nucl Med

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“…Solid state detectors allow direct photon detection and they are characterized by significantly higher energy resolution. 97 This can be crucial in applications where multiple radiotracers are administered in small animals or even humans. 98 However, the development of such systems has several technical challenges, which limits their spread.…”

Section: Micro-spectmentioning

confidence: 99%

In vivo small animal imaging: Current status and future prospects

et al. 2010

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The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to commercial translation to clinical practice. Whole-body small animal imaging is a particularly elegant and cost-effective experimental platform for the timely validation and commercialization of novel agents from the bench to the bedside. Biomedical imaging is now listed along with genomics, proteomics, and metabolomics as an integral part of biological and medical sciences. Miniaturized versions of clinical diagnostic modalities, including but not limited to microcomputed tomography, micromagnetic resonance tomography, microsinglephoton-emission tomography, micropositron-emission tomography, optical imaging, digital angiography, and ultrasound, have all greatly improved our investigative abilities to longitudinally study various experimental models of human disease in mice and rodents. After an exhaustive literature search, the authors present a concise and critical review of in vivo small animal imaging, focusing on currently available modalities as well as emerging imaging technologies on one side and molecularly targeted contrast agents on the other. Aforementioned scientific topics are analyzed in the context of cancer angiogenesis and innovative antiangiogenic strategies under-the-way to the clinic. Proposed hybrid approaches for diagnosis and targeted site-specific therapy are highlighted to offer an intriguing glimpse of the future.

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“…Detector-1 was modeled in consideration with a realistic monolithic semiconductor detector such as MGC-700T2 (Oy Ajat, Finland) [12], and Detector-2 with a realistic modular-type semiconductor detector such as OMS40G256 (Orbotech Co., Israel) [10]. Detector-3 was modeled with a commonly used detector in small animal pinhole SPECT systems.…”

Section: Detector-1 (Pixelated Monolithic Detector)mentioning

confidence: 99%

“…On the other hand, the intrinsic spatial resolution of a conventional NaI(Tl) scintillation detector with photomultiplier tubes, which is used for typical SPECT systems, is approximately 4.0 mm FWHM (full width at half maximum). To improve the system spatial resolution with a geometrical magnification effect, a pinhole collimator is used with a non-pixelated scintillation detector [5,6] or pixelated semiconductor detector such as CdTe or CdZnTe [7][8][9][10]. The advantages of pixelated semiconductor detectors are a high intrinsic spatial resolution and energy resolution, while their disadvantages are a high manufacturing cost and small detector field.…”

Section: Introductionmentioning

confidence: 99%

Comparison of a pixelated semiconductor detector and a non-pixelated scintillation detector in pinhole SPECT system for small animal study

Iida

Ogawa

2010

Ann Nucl Med

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Development of an ultra-high resolution SPECT system with a CdTe semiconductor detector

Abstract: Our results demonstrated that the ultra-high spatial resolution SPECT system was feasible for small animal imaging allowing a relatively long data acquisition time.

Cited by 37 publications

References 30 publications

Using the NEMA NU 4 PET Image Quality Phantom in Multipinhole Small-Animal SPECT

Using the NEMA NU 4 PET Image Quality Phantom in Multipinhole Small-Animal SPECT

In vivo small animal imaging: Current status and future prospects

Comparison of a pixelated semiconductor detector and a non-pixelated scintillation detector in pinhole SPECT system for small animal study

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